Surface tunability of nanoparticles in modulating platelet functions

Deb, Suryyani; Raja, Sufi O.; Dasgupta, Anjan K.; Sarkar, Rajkumar; Chattopadhyay, Asoke P.; Chaudhuri, Utpal; Guha, Pradipta; Sardar, Partha

doi:10.1016/j.bcmd.2011.09.011

Cited by 36 publications

(29 citation statements)

References 20 publications

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“…Dynamic light scattering studies confirm nearly mono-dispersed (polydispersity index ~ 0.27) population of synthesized citrate coated iron oxide nanoparticles with mean size of ~20 nm (see Figure S1). Atomic force microscopic analysis and surface conjugation of this nanoparticle was shown previously by us 23 . Here we performed detailed magnetic analysis of iron oxide nanoparticles using Vibrational Sample Magnetometer (VSM).…”

Section: Resultssupporting

confidence: 59%

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Antiferromagnetic switch in serum

Raja

Chatterjee

Dasgupta

2017

Preprint

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Ferritin contains naturally occurring iron oxide nanoparticle surrounded by a structured spherical array of peptide residues that provides tremendous stability to this iron storage protein.We use synthetic citrate coated Super Paramagnetic Iron Oxide Nanoparticles (SPIONs) and static magnetic field in exploring the Ferritin induced magnetic environment of human serum samples with varying ferritin level collected from thalassemic patients. We report antiferromagnetic properties of serum in patients with iron overloading. Magnetic pulling by an external magnetic field showed a cusp-like behavior with increasing concentration of serum Ferritin measured by standard ELISA based kit. A reduction in the extent of pulling after a threshold concentration of Ferritin (1500 ng/ml) suggests a Ferritin dependent magnetic switching.Negative magnetization (anti-ferromagnetization) was confirmed by Vibrating Sample Magnetometric (VSM) analysis of SPION-serum mixture containing very high level of Ferritin. Such magnetic switching may have a possible role in iron homeostasis during overloading of Ferritin. 2.

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Section: Resultssupporting

confidence: 59%

“…The detail of the synthesis protocol is described elsewhere 23 . Briefly, we have prepared iron oxide nanoparticles by co-precipitating 2gm ferrous chloride and 4gm ferric chloride (solubilized in 50 ml 2(N) HCl) by 100ml 1.5(N) sodium hydroxide upon constant stirring at room temperature.…”

Section: Synthesis Of Iron Oxide Nanoparticlesmentioning

confidence: 99%

Antiferromagnetic switch in serum

Raja

Chatterjee

Dasgupta

2017

Preprint

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“…Available literature reports varied platelet responses for iron oxide nanoparticles with different surface functionality. For example, citric acid functionalized iron oxide nanoparticles was shown to possess anti-platelet activity, while starch coated iron oxide nanoparticles behaved neutrally [23]. The polymer dextran has been shown to possess anti-thrombotic and anti-platelet function [24].…”

Section: Discussionmentioning

confidence: 99%

In vitro hematological and in vivo immunotoxicity assessment of dextran stabilized iron oxide nanoparticles

Easo

Mohanan

2015

Colloids and Surfaces B: Biointerfaces

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“…It appears that PEGylation of particles is not suitable for all particles and particle-specific coatings need to be developed. Coating with starch reduced platelet aggregation to iron oxide NPs [134]. A stealth formulation consisting of PEG and dipalmitoylphosphatidylcholine (DPPC) reduced platelet activation and inhibited agonist (ADP) induced activation of polymeric particles [135].…”

Section: How To Prevent Adverse Effects On Hemostasismentioning

confidence: 99%

Action of Nanoparticles on Platelet Activation and Plasmatic Coagulation

Frőhlich

2016

CMC

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Nanomaterials can get into the blood circulation after injection or by release from implants but also by permeation of the epithelium after oral, respiratory or dermal exposure. Once in the blood, they can affect hemostasis, which is usually not intended. This review addresses effects of biological particles and engineered nanomaterials on hemostasis. The role of platelets and coagulation in normal clotting and the interaction with the immune system are described. Methods to identify effects of nanomaterials on clotting and results from in vitro and in vivo studies are summarized and the role of particle size and surface properties discussed. The literature overview showed that mainly pro-coagulative effects of nanomaterials have been described. In vitro studies suggested stronger effects of smaller than of larger NPs on coagulation and a greater importance of material than of surface charge. For instance, carbon nanotubes, polystyrene particles, and dendrimers inferred with clotting independent from their surface charge. Coating of particles with polyethylene glycol was able to prevent interaction with clotting by some particles, while it had no effect on others and the more recently developed bio-inspired surfaces might help to design coatings for more biocompatible particles. The mainly pro-coagulative action of nanoparticles could present a particular risk for individuals affected by common diseases such as diabetes, cancer, and cardiovascular diseases. Under standardized conditions, in vitro assays using human blood appear to be a suitable tool to study mechanisms of interference with hemostasis and to optimize hemocompatibility of nanomaterials.

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Surface tunability of nanoparticles in modulating platelet functions

Cited by 36 publications

References 20 publications

Antiferromagnetic switch in serum

Antiferromagnetic switch in serum

In vitro hematological and in vivo immunotoxicity assessment of dextran stabilized iron oxide nanoparticles

Action of Nanoparticles on Platelet Activation and Plasmatic Coagulation

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