Surface treatments for surface plasmon resonance biosensors

Zhu, Xiaowei; Lin, Po‐Chiao; Ao, Ping; Sorensen, L. B.

doi:10.1016/s0925-4005(01)01080-2

Cited by 35 publications

(19 citation statements)

References 19 publications

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“…However, the sensitivity of the SPR imaging biosensor has a potential limitation, because silver is highly susceptible to oxidation. While the use of a thin gold film might be a better choice in terms of stability and reliability, silver would be a promising candidate for sensitive SPR imaging detection if silver surfaces can be made chemically inert [7]. Despite the great sensitivity of a silver film, when a homogeneous silver oxide layer is formed by processing the silver film in an oxygen-containing atmosphere, the imaging sensitivity is decreased with an increasing silver oxide thickness because the oxide coating makes SPR curves broader [8].…”

Section: Introductionmentioning

confidence: 99%

Graphene-on-silver substrates for sensitive surface plasmon resonance imaging biosensors

2011

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Taking advantage of the high impermeability property of graphene and the sharp surface plasmon resonance (SPR) curve of silver, we numerically demonstrate that SPR imaging biosensors with a graphene-on-silver substrate can be used to achieve the dramatically high sensitivity as well as to prevent silver oxidation. Results of our numerical study show that a silver substrate with a few graphene layers can significantly increase the imaging sensitivity, compared to the conventional gold-film-based SPR imaging biosensor. In particular, single layered graphene deposited on the 60-nm thick silver film amplifies the SPR imaging signal more than three times. Therefore, the proposed SPR substrate could potentially open a new possibility of SPR imaging detection for sensitive and high-throughput assessment of multiple biomolecular interactions.

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Section: Introductionmentioning

confidence: 99%

Graphene-on-silver substrates for sensitive surface plasmon resonance imaging biosensors

2011

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“…It possesses very fascinating optical, mechanical and electrical properties which have attracted many researchers and scientists all over the world. The advantage of graphene on gold is that it helps to adsorb more and more ring-type biomolecules [12], and in case of silver, the advantage is that it prevents the oxidation of silver layer [13][14][15]. Recently, Verma et al [16] have demonstrated theoretically that the addition of silicon (Si) layer between gold and graphene enhances the sensitivity of SPR biosensor twice the value reported in the literature.…”

Section: Introductionmentioning

confidence: 99%

Effect of Semiconductor on Sensitivity of a Graphene-Based Surface Plasmon Resonance Biosensor

2015

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In this theoretical study, the effect of semiconductor on sensitivity of a graphene-based surface plasmon resonance (SPR) biosensor has been presented. Different semiconductors such as silicon (Si), germanium (Ge) and wurtzite III-V nitrides (AlN, GaN and InN) have been placed in between active silver (Ag) metal and graphene layer. Our simulation result shows that addition of semiconductor layer enhances the sensitivity by a factor of 3.76, 2.19, 3.82, 3.94 and 4.17 respectively for Si, Ge, InN, GaN and AlN. Also, we have examined the field enhancement factor due to above semiconductors and found maximum field intensity enhancement for the case of AlN. The analysis shows that best performance is achieved for red He-Ne laser light when optimized thicknesses of silver, AlN and graphene layer are 55, 14 and 0.34 nm (monolayer of graphene), respectively. More specifically, AlN would be a better choice for biosensing application in SPR biosensor.

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“…On the other hand, regardless of the advantage of gold films, which tend to be chemically stable, SPR imaging systems based on gold substrates suffer from relatively low detection accuracy arising from insufficient sensitivity. In other words, regarding stability and reliability considerations in actual experiments, although the use of a thin gold film might be a better choice, silver films would be potential candidates for practical SPR substrates if coated silver surfaces could be made chemically inert [9]. Therefore, in this paper, we theoretically consider a SPR imaging structure based on a thin silver film in order to improve the sensitivity of intensity measurements.…”

Section: Introductionmentioning

confidence: 99%

Investigation on an application of silver substrates for sensitive surface plasmon resonance imaging detection

Choi¹,

Byun²

2010

J. Opt. Soc. Am. A

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A surface plasmon resonance (SPR) imaging biosensor based on silver substrates was investigated to demonstrate that silver could be used as a substrate material for sensitive detection of biomolecular interactions, despite its poor chemical stability. The calculation results showed that oxidation of silver film may lead to a decrease in the sensitivity due to a variation in SPR characteristics such as a broader curve width and shallower minimum reflectance at resonance. The effect of a change in the refractive index of target analytes on the sensitivity was also explored. In particular, it is noteworthy that Ag/Au bimetallic substrates with a thin gold protection layer to prevent oxidation of a silver film can provide a significant amplification of SPR imaging signals in comparison with conventional gold substrates.

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Surface treatments for surface plasmon resonance biosensors

Cited by 35 publications

References 19 publications

Graphene-on-silver substrates for sensitive surface plasmon resonance imaging biosensors

Graphene-on-silver substrates for sensitive surface plasmon resonance imaging biosensors

Effect of Semiconductor on Sensitivity of a Graphene-Based Surface Plasmon Resonance Biosensor

Investigation on an application of silver substrates for sensitive surface plasmon resonance imaging detection

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