Surface Treatment of Flexor Tendon Autografts With Carbodiimide-Derivatized Hyaluronic Acid

Surface Modification with Chemically Modified Synovial Fluid for Flexor Tendon Reconstruction in a Canine Model in Vivo

“…Digital function was evaluated on the basis of the work of flexion (WOF), determined using a previously established method 28,29 . WOF data were calculated from the tendon-displacement versus tendon-loading curve during digital flexion.…”

“…WOF data were calculated from the tendon-displacement versus tendon-loading curve during digital flexion. Data were then normalized (nWOF) by the total proximal interphalangeal and distal interphalangeal joint angles using previously established methods 20,29 .…”

“…After evaluation of adhesion in the zone-II area, the tendon graft was further dissected for testing of gliding resistance, performed with use of a custom tendon pulley-friction testing apparatus, as previous described 29,30 . The tendon graft was transected 15 mm proximal to the distal attachment site, and the proximal pulley and the proximal phalanx were mounted on a clamp.…”

“…Although EDC was shown to have little toxicity in tissue-engineering studies 29,44 , it has the potential, with higher doses or longer exposure, to diffusely stiffen the tendon, by increasing the number of crosslinks between collagen molecules within the tendon 45 . In this in vivo animal study, this potentially adverse effect of EDC on tendon stiffness was addressed.…”

An Experimental Model on the Biomechanical Behaviour of the Flexor Tendons in New Zealand Rabbits

“…[11][12][13][14][15][16][17][18][19] In this direction, there have been some extensive studies on drugs that can function in a complementary way for the inhibition of tendon adhesions. In developing new pharmacological agents intended to inhibit the creation of adhesions, it is imperative to test these products on laboratory animals under a protocol that can evaluate both the range of motion and functional stiffness of healing of the tendons.…”