Surface tension effects on flow dynamics and alveolar mechanics in the acinar region of human lung

Francis, Isabella; Saha, Suvash C.

doi:10.1016/j.heliyon.2022.e11026

Cited by 7 publications

(6 citation statements)

References 32 publications

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“…It describes the ability of a liquid to keep a minimal surface area. Surface tension at liquid/air interfaces is caused by the higher intermolecular attractions in the liquid (cohesion) compared to molecule attraction with air (adhesion) [57]. There are two main active systems.…”

Section: Surface Tension and Viscositymentioning

confidence: 99%

Why Carbon Nanotubes Improve Aqueous Nanofluid Thermal Conductivity: A Qualitative Model

Khoswan,

Nassar,

Assali

et al. 2024

Preprint

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Media thermal conductivity is important in various heat-transfer processes. Many conventional fluid conductors suffered low conductivity and environmental issues. Therefore, researchers developed efficient aqueous nanofluid conductors. Carbon nanotubes (CNTs) are widely studied to reach efficient, stable, low-cost and environmentally-friendly aqueous-nanofluids. This review provides a clear understanding of how CNTs improve thermal conductivity of aqueous nanofluids. A qualitative model is presented to explain literature mechanisms behind improvement. CNT type effects are discussed with other factors such as aspect ratio, Reynold number, dispersion quality, composition, temperature and additives. CNT functionalization is described. Relations to estimate nanofluid thermal conductivity are discussed. The model will help specialists to tailor CNT aqueous nanofluids as desired.

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Section: Surface Tension and Viscositymentioning

confidence: 99%

Why Carbon Nanotubes Improve Aqueous Nanofluid Thermal Conductivity: A Qualitative Model

Khoswan,

Nassar,

Assali

et al. 2024

Preprint

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“…Irregularly shaped particles are more likely to deposit in the airways compared to spherical particles of the same size. Morphology of the lung: Lung surfactant and mucus movement also play important roles in airflow movement, particle residence, and proper compliance and recoil of lung alveolar [ 74 ]. Boundary conditions: Most of the CFD studies, including the recent work [ 63 ], used the inlet as a boundary condition of the mouth or nose or trachea from where particles and air enter the lung airways.…”

Section: Introductionmentioning

confidence: 99%

“…Morphology of the lung: Lung surfactant and mucus movement also play important roles in airflow movement, particle residence, and proper compliance and recoil of lung alveolar [ 74 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of microplastics deposition on human lung airways: A review with computational benefits and challenges

Saha,

Saha

2024

Heliyon

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“…The exploration of fluid flow-induced wall shear stress within human biological organs stands as a foundational pillar of medical research, wielding a transformative influence on our comprehension of physiological dynamics, encompassing both states of health and pathophysiological conditions. This investigation has unfolded across a diverse spectrum, extending its purview into evaluations of shear stress within healthy and diseased lungs under varying surface tension conditions [1,2], scrutinizing bone scaffolds [3], and conducting comprehensive assessments of wall shear stress in AAAs [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Hemodynamic Insights into Abdominal Aortic Aneurysms: Bridging the Knowledge Gap for Improved Patient Care

Saha,

Francis,

Saha

et al. 2024

Fluids

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Background: Abdominal aortic aneurysms (AAAs) present a formidable public health concern due to their propensity for localized, anomalous expansion of the abdominal aorta. These insidious dilations, often in their early stages, mask the life-threatening potential for rupture, which carries a grave prognosis. Understanding the hemodynamic intricacies governing AAAs is paramount for predicting aneurysmal growth and the imminent risk of rupture. Objective: Our extensive investigation delves into this complex hemodynamic environment intrinsic to AAAs, utilizing comprehensive numerical analyses of the physiological pulsatile blood flow and realistic boundary conditions to explore the multifaceted dynamics influencing aneurysm rupture risk. Our study introduces novel elements by integrating these parameters into the overall context of aneurysm pathophysiology, thus advancing our understanding of the intricate mechanics governing their evolution and rupture. Methods: Conservation of mass and momentum equations are used to model the blood flow in an AAAs, and these equations are solved using a finite volume-based ANSYS Fluent solver. Resistance pressure outlets following a three-element Windkessel model were imposed at each outlet to accurately model the blood flow and the AAAs’ shear stress. Results: Our results uncover elevated blood flow velocities within an aneurysm, suggesting an augmented risk of future rupture due to increased stress in the aneurysm wall. During the systole phase, high wall shear stress (WSS) was observed, typically associated with a lower risk of rupture, while a low oscillatory shear index (OSI) was noted, correlating with a decreased risk of aneurysm expansion. Conversely, during the diastole phase, low WSS and a high OSI were identified, potentially weakening the aneurysm wall, thereby promoting expansion and rupture. Conclusion: Our study underscores the indispensable role of computational fluid dynamic (CFD) techniques in the diagnostic, therapeutic, and monitoring realms of AAAs. This body of research significantly advances our understanding of aneurysm pathophysiology, thus offering pivotal insights into the intricate mechanics underpinning their progression and rupture, informing clinical interventions and enhancing patient care.

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Surface tension effects on flow dynamics and alveolar mechanics in the acinar region of human lung

Cited by 7 publications

References 32 publications

Why Carbon Nanotubes Improve Aqueous Nanofluid Thermal Conductivity: A Qualitative Model

Why Carbon Nanotubes Improve Aqueous Nanofluid Thermal Conductivity: A Qualitative Model

Effect of microplastics deposition on human lung airways: A review with computational benefits and challenges

Hemodynamic Insights into Abdominal Aortic Aneurysms: Bridging the Knowledge Gap for Improved Patient Care

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