Surface studies with optical second-harmonic generation

Heinz, Tony F.; Reider, Georg A.

doi:10.1016/0165-9936(89)87009-8

Cited by 23 publications

(7 citation statements)

References 52 publications

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“…SHS is based on the nonlinear optical phenomenon second-harmonic generation (SHG), in which incident light of frequency ω induces a polarization of frequency 2ω (ω SH ) in an SH-active matter. The induced polarization then serves as a source of the light scattered at 2ω − (see Figure A). Specifically, the SH photon scattered from a molecule is produced by an induced dipole moment of (1/2)×β| E · E |, where E is the photon’s electric field strength and β is molecular first-hyperpolarizability: , The term ω s is the frequency that corresponds to the energy gap between the ground state (S 0 ) and the upper state (S n ), f s is the oscillator strength that describes the optical transition probability from state S 0 to S n , and Δμ s denotes the dipole moment change upon the optical transition.…”

Section: Passive Membrane Permeation Measurementsmentioning

confidence: 99%

Recent Experimental Developments in Studying Passive Membrane Transport of Drug Molecules

Gh.

2021

Mol. Pharmaceutics

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The ability to measure the passive membrane permeation of drug-like molecules is of fundamental biological and pharmaceutical importance. Of significance, passive diffusion across the cellular membranes plays an effective role in the delivery of many pharmaceutical agents to intracellular targets. Hence, approaches for quantitative measurement of membrane permeability have been the topics of research for decades, resulting in sophisticated biomimetic systems coupled with advanced techniques. In this review, recent developments in experimental approaches along with theoretical models for quantitative and real-time analysis of membrane transport of drug-like molecules through mimetic and living cell membranes are discussed. The focus is on time-resolved fluorescence-based, surface plasmon resonance, and second-harmonic light scattering approaches. The current understanding of how properties of the membrane and permeant affect the permeation process is discussed.

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Section: Passive Membrane Permeation Measurementsmentioning

confidence: 99%

Recent Experimental Developments in Studying Passive Membrane Transport of Drug Molecules

Gh.

2021

Mol. Pharmaceutics

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“…Let us now provide some estimates, which allow us to assert that the differences in the nonlinear scattering modes in Figures 2 and 4 are precisely due to the excitation of plasmon resonance during breakdown inside the bubstons. Despite the fact that in the bulk of isotropic liquids the quadratic optical nonlinearity is absent, [1] the effects of quadratic nonlinearity may reveal close to the inter-phase boundaries, [3][4][5] that is, in dispersed mixtures. The presence of nanobubbles with a size of $300 nm in a liquid indicates that we are dealing with such a dispersed mixture, where water molecules close to the inter-phase boundaries have quasi-crystalline properties, and the effects of quadratic nonlinearity become possible.…”

Section: Resultsmentioning

confidence: 99%

“…Note that the second‐harmonic generation is used as an effective probe for the liquid surface. [ 3–5 ]…”

Section: Introductionmentioning

confidence: 99%

Nonlinear light scattering spectra in water: Dependence on the content of dissolved gas and effects of non‐stationarity

Bunkin

Бабенко

Sychev

2022

J Raman Spectroscopy

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“…Nonlinear optical methods, − such as optical second harmonic generation (SHG) and sum frequency generation (SFG), have been proved to be useful for application to chemistry and physics in nanoscale science and technology. SHG is one of the second-order nonlinear optical effects and is the conversion of two photons with frequency ω into one photon with a frequency of 2 ω.…”

Section: Introductionmentioning

confidence: 99%

Electrodeposition of Flattened Cu Nanoclusters on a p-GaAs(001) Electrode Monitored by in situ Optical Second Harmonic Generation

et al. 2005

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In situ optical second harmonic generation (SHG) technique was employed to investigate the shape and density of Cu nanoclusters, which were electrochemically formed on p-GaAs(001) electrode surfaces. Since GaAs is not a centrosymmetric medium, a significant portion of SHG signal arises from the bulk dipole susceptibility, but it was possible to separate a surface-induced signal from a bulk-induced signal by choosing an appropriate experimental geometry and appropriate data processing. The rotational anisotropy (RA) pattern of the SHG signal from a p-GaAs(001) electrode changed in both shape and magnitude during potential cycling in an electrolyte solution containing Cu 2+ . The surface plasmon-induced SHG signal from Cu nanoclusters deposited on GaAs was attributed to the modulation source for the RA-SHG pattern. More detailed study was carried out with both in situ SHG and ex situ AFM measurements for Cu nanoclusters deposited by potential step. The results showed that the SHG signal at the present optical geometry was sensitive to the number of oblate or flattened Cu nanoclusters with lateral diameter larger than 30 nm and that the SHG enhancement occurred because of resonant coupling between the surface plasmon induced in the flattened Cu nanoclusters and the near-infrared fundamental light.

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Surface studies with optical second-harmonic generation

Cited by 23 publications

References 52 publications

Recent Experimental Developments in Studying Passive Membrane Transport of Drug Molecules

Recent Experimental Developments in Studying Passive Membrane Transport of Drug Molecules

Nonlinear light scattering spectra in water: Dependence on the content of dissolved gas and effects of non‐stationarity

Electrodeposition of Flattened Cu Nanoclusters on a p-GaAs(001) Electrode Monitored by in situ Optical Second Harmonic Generation

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