Surface roughness of silk fibroin/alginate microspheres for rapid hemostasis in vitro and in vivo

Huang, Xiangfeng; Fu, Qiang; Deng, Yaxin; Wang, Fuping; Xia, Bin; Chen, Zhongmin; Chen, Guobao

doi:10.1016/j.carbpol.2020.117256

Cited by 69 publications

(33 citation statements)

References 61 publications

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“…2 In the case of life-threatening traumatic bleeding, timely and effective treatment must be administered during the hemostasis phase to minimize blood loss and improve the chance of survival. 3 Knowing that injured skin can easily get infected and that bacterial infection may delay wound healing and bring about life-threatening complications, 4 it is important to properly care for an injury by applying a functional and efficient wound dressing. Today, clinicians rely on hydrogels, films and sponges to dress wounds.…”

Section: Introductionmentioning

confidence: 99%

Silk fibroin/chitosan hydrogel with antibacterial, hemostatic and sustained drug‐release activities

Chen

Zhang

et al. 2021

Polymer International

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Hydrogels are viable wound dressing materials that have gained increasing attention due to their specific physicochemical properties, biocompatibility and environmental responsiveness. In addition to keeping a wound area moist, hydrogels characterized by a porous network structure and regulated drug-release capacity promote the various phases of wound healing by effectively loading a drug and inducing anti-infection activity. In this study, we prepared a multifunctional hydrogel with antibacterial, hemostatic and sustained drug-release activities by chemically crosslinking silk fibroin (SF) and chitosan (CS) biomacromolecules. Results of characterization revealed that the synthesized hydrogel presents higher swelling and in vitro degradation rates under acidic conditions than in a neutral environment. Moreover, the three-dimensional network structure of the material and the transformation of the SF secondary structure resulted in enhanced compressive mechanical properties (maximum compressive stress of 50-130 kPa). In vitro studies of drug loading and release, antibacterial assay, cytotoxicity studies, and coagulation assay were performed. Results showed that the prepared hydrogel exhibits good bacteriostatic and hemostatic properties, and it is not toxic towards human skin fibroblasts. Therefore, the designed SF/CS hydrogel constitutes an excellent candidate material for wound dressings.

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Section: Introductionmentioning

confidence: 99%

Silk fibroin/chitosan hydrogel with antibacterial, hemostatic and sustained drug‐release activities

Chen

Zhang

et al. 2021

Polymer International

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“…CSCM may be useful in controlling hemorrhage in military and civilian emergencies. Huang et al obtained silk fibroin (SF)/sodium alginate (SA) microspheres by emulsifying cross-linking [ 132 ]. The rough surface of SF/SA microspheres increased the cell adhesion ability.…”

Section: Hemostasis Of Deep and Irregular Woundsmentioning

confidence: 99%

Application of Alginate-Based Hydrogels in Hemostasis

Xie

Gao

et al. 2022

Gels

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Hemorrhage, as a common trauma injury and clinical postoperative complication, may cause serious damage to the body, especially for patients with huge blood loss and coagulation dysfunction. Timely and effective hemostasis and avoidance of bleeding are of great significance for reducing body damage and improving the survival rate and quality of life of patients. Alginate is considered to be an excellent hemostatic polymer-based biomaterial due to its excellent biocompatibility, biodegradability, non-toxicity, non-immunogenicity, easy gelation and easy availability. In recent years, alginate hydrogels have been more and more widely used in the medical field, and a series of hemostatic related products have been developed such as medical dressings, hemostatic needles, transcatheter interventional embolization preparations, microneedles, injectable hydrogels, and hemostatic powders. The development and application prospects are extremely broad. This manuscript reviews the structure, properties and history of alginate, as well as the research progress of alginate hydrogels in clinical applications related to hemostasis. This review also discusses the current limitations and possible future development prospects of alginate hydrogels in hemostatic applications.

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“…Huang et al prepared hemostatic microspheres with different degrees of surface roughness by cross-linking sodium alginate and SF in order to accelerate the blood coagulation. The results showed that when the volume ratio of SA to SF was adjusted to 2:1 (SF/SA2), the surface of the microspheres was the roughest, and thus more red blood cells could be aggregated and the coagulation speed of the hemostatic agent was apparently accelerated ( Huang et al, 2021b ). Shefa et al constructed a hydrogel scaffold using oxidized cellulose nanofibers and SF, and explored the effect of thrombin loading on the hemostatic properties of this scaffold.…”

Section: Protein-based Hemostatic Hydrogelsmentioning

confidence: 99%

Hydrogel-Based Biomaterials Engineered from Natural-Derived Polysaccharides and Proteins for Hemostasis and Wound Healing

Jin

Liu

et al. 2021

Front. Bioeng. Biotechnol.

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Rapid and effective hemostasis is of great importance to improve the quality of treatment and save lives in emergency, surgical practice, civilian, and military settings. Traditional hemostatic materials such as tourniquets, gauze, bandages, and sponges have shown limited efficacy in the management of uncontrollable bleeding, resulting in widespread interest in the development of novel hemostatic materials and techniques. Benefiting from biocompatibility, degradability, injectability, tunable mechanical properties, and potential abilities to promote coagulation, wound healing, and anti-infection, hydrogel-based biomaterials, especially those on the basis of natural polysaccharides and proteins, have been increasingly explored in preclinical studies over the past few years. Despite the exciting research progress and initial commercial development of several hemostatic hydrogels, there is still a significant distance from the desired hemostatic effect applicable to clinical treatment. In this review, after elucidating the process of biological hemostasis, the latest progress of hydrogel biomaterials engineered from natural polysaccharides and proteins for hemostasis is discussed on the basis of comprehensive literature review. We have focused on the preparation strategies, physicochemical properties, hemostatic and wound-healing abilities of these novel biomaterials, and highlighted the challenges that needed to be addressed to achieve the transformation of laboratory research into clinical practice, and finally presented future research directions in this area.

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Surface roughness of silk fibroin/alginate microspheres for rapid hemostasis in vitro and in vivo

Cited by 69 publications

References 61 publications

Silk fibroin/chitosan hydrogel with antibacterial, hemostatic and sustained drug‐release activities

Silk fibroin/chitosan hydrogel with antibacterial, hemostatic and sustained drug‐release activities

Application of Alginate-Based Hydrogels in Hemostasis

Hydrogel-Based Biomaterials Engineered from Natural-Derived Polysaccharides and Proteins for Hemostasis and Wound Healing

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