Surface Roughness of Cellulose Hollow Fiber Dialysis Membranes and Platelet Adhesion

Tsunoda, Nanae; Kokubo, Kenichi; Sakai, Kiyotaka; Fukuda, Makoto; Miyazaki, Masaru; Hiyoshi, Tatsuo

doi:10.1097/00002480-199909000-00010

Cited by 44 publications

(27 citation statements)

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“…During static test conditions no differences between smooth and rough surfaces were found [171, 172]. The higher platelet adhesion on rough hydrophilic cellulose was in agreement with these observations [173]. …”

Section: Biomaterials Surface Characteristics In Relation To Haemocsupporting

confidence: 59%

Obstacles in Haemocompatibility Testing

Oeveren¹

2013

Scientifica

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ISO 10993-4 is an international standard describing the methods of testing of medical devices for interactions with blood for regulatory purpose. The complexity of blood responses to biomaterial surfaces and the variability of blood functions in different individuals and species pose difficulties in standardisation. Moreover, in vivo or in vitro testing, as well as the clinical relevance of certain findings, is still matter of debate. This review deals with the major remaining problems, including a brief explanation of surface interactions with blood, the current ISO 10993 requirements for testing, and the role of in vitro test models. The literature is reviewed on anticoagulation, shear rate, blood-air interfaces, incubation time, and the importance of evaluation of the surface area after blood contact. Two test categories deserve further attention: complement and platelet function, including the effects on platelets from adhesion proteins, venipuncture, and animal derived- blood. The material properties, hydrophilicity, and roughness, as well as reference materials, are discussed. Finally this review calls for completing the acceptance criteria in the ISO standard based on a panel of test results.

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Section: Biomaterials Surface Characteristics In Relation To Haemocsupporting

confidence: 59%

Obstacles in Haemocompatibility Testing

Oeveren¹

2013

Scientifica

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“…It has been reported that platelet adhesion is associated with roughness of the membrane surface in cellulose-based membranes [22]. Similarly, the roughness of PS membranes is associated with albumin adsorption [23].…”

Section: Newly Developed Dialysis and Filtration Membranesmentioning

confidence: 99%

Evaluation of the Biocompatibility of Dialysis Membranes

Kokubo

Kurihara²,

Kobayashi³

et al. 2015

Blood Purif

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Background: Improvements in the biocompatibility of dialysis membranes have reduced biological responses elicited by blood-membrane interactions. In this article, recent technological developments in dialysis membranes with regard to biocompatibility and recent progress in the evaluation of the biocompatibility of dialysis membranes are reviewed. Summary: The focus of investigation into dialysis membranes in recent years has focused on not only membrane materials, but also their surface textures, which have been changed, for example, by coating with vitamin E or by changing the amount and type of hydrophilizing agents used. Research and development is directed at altering the chemical and physical properties of membrane surfaces to suppress biological responses that are particularly elicited as a result of platelet activation. To develop membranes with excellent biocompatibility, biocompatibility should be evaluated on a like-for-like basis under conditions that are similar to those in clinical settings. Evaluation using actual dialyzers can be performed using porcine blood, platelet-rich plasma isolated from porcine blood (and platelet-rich plasma with leukocytes), or suspension of neutrophils isolated from porcine blood or cultured human monocytes. Key Messages: Highly biocompatible dialysis membranes can be developed when the overall correlations among biological reactions are examined by integrating all data on biological responses elicited by blood-membrane interactions or mutual interactions among blood cells.

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“…The data of RMS indicated that the surface roughness of the modified PE membrane was evidently lower than that of the original one. The modification smoothened the PE membrane surfaces, thus facilitated the decrease of water contact angle and improvement of hemocompatibility and anti-fouling ability [14][15][16].…”

Section: Membrane Surface Morphologymentioning

confidence: 99%