Surface roughness effects on the tribo-charging and mixing homogeneity of adhesive mixtures used in dry powder inhalers

Karner, Stefan; Maier, M.; Littringer, Eva Maria; Urbanetz, Nora Anne

doi:10.1016/j.powtec.2014.03.040

Cited by 21 publications

(10 citation statements)

References 15 publications

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“…Wall layer development in a tribocharged fluidized bed 861 as impurities and oxides, surface roughness, object geometry and relative humidity, which pose challenges in numerical modelling (Castle 1997;Karner et al 2014;Schella, Herminghaus & Schroter 2017).…”

mentioning

confidence: 99%

Experimental and numerical study of wall layer development in a tribocharged fluidized bed

Sippola

Kolehmainen

Özel³

et al. 2018

J. Fluid Mech.

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The effects of triboelectricity in a small-scale fluidized bed of polyethylene particles were investigated by imaging the particle layer in the vicinity of the column wall and by measuring the pressure drop across the bed. The average charge on the particles was altered by changing the relative humidity of the gas. A triboelectric charging model coupled with a computational fluid dynamics-discrete element method (CFD-DEM) model was utilized to simulate gas-particle flow in the bed. The electrostatic forces were evaluated based on a particle-particle particle-mesh method, accounting for the surface charge on the insulating walls. It was found that simulations with fixed and uniform charge distribution among the particles capture remarkably well both the agglomeration of the particles on the wall and the associated decrease in the pressure drop across the bed. With a dynamic tribocharging model, the charging rate had to be accelerated to render the computations affordable. Such simulations with an artificial acceleration significantly over-predict charge segregation and the wall becomes rapidly sheeted with a single layer of strongly charged particles.

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mentioning

confidence: 99%

Experimental and numerical study of wall layer development in a tribocharged fluidized bed

Sippola

Kolehmainen

Özel³

et al. 2018

J. Fluid Mech.

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“…The theoretical primary aerodynamic diameter of the particles (D ae ) is estimated from the average particle size (D 50 ) and tapped density data ( tap ) using [31,32]: (3) where 1 = 1 g/cm 3 …”

Section: Particle Size Powder Density Carr Index Hausner Ratio Andmentioning

confidence: 99%

“…In the preparation of inhalable medications, small particles of active pharmaceutical ingredients (API) are mixed with large carrier particles [3]. In order to aerosolize the drug particles, the properties of both the carriers and the API particles are of great importance since the drug-carrier adhesive forces need to be overcome by the patient's inspiratory force [4].…”

Section: Introductionmentioning

confidence: 99%

Combined control of morphology and polymorph in spray drying of mannitol for dry powder inhalation

Lyu

Liu

Zhang

et al. 2017

Journal of Crystal Growth

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The morphology and polymorphism of mannitol particles were controlled during spray drying with the aim of improving the aerosolization properties of inhalable dry powders. The obtained microparticles were characterized using scanning electron microscopy, infrared spectroscopy, differential scanning calorimetry, powder X-ray diffraction and inhaler testing with a next generation impactor. Mannitol particles of varied -mannitol content and surface roughness were prepared via spray drying by manipulating the concentration of NH 4 HCO 3 in the feed solution. The bubbles produced by NH 4 HCO 3 led to the formation of spheroid particles with a rough surface. Further, the fine particle fraction was increased by the rough surface of carriers and the high -mannitol content.Inhalable dry powders with a 29.1 ± 2.4% fine particle fraction were obtained by spray-drying using 5% mannitol (w/v)/2% NH 4 HCO 3 (w/v) as the feed solution, proving that this technique is an effective method to engineer particles for dry powder inhalation.

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“…3) to evaluate both the cohesive and adhesive interactions between materials used in drug delivery (Adi et al, 2007;Beilmann et al, 2007;De Boer et al, 2003a,b;Eve et al, 2002;James et al, 2008;Karner et al, 2014;Louey et al, 2001;Price et al, 2002;Sindel and Zimmermann, 2001;Tsukada et al, 2004;Young et al, 2009) and, quite recently, the mechanism of particle detachment (Cui and Sommerfeld, 2015). While three different scenarios describing the process of particle detachment-lift-off, sliding and rolling-are possible, a combination of colloidal probe measurements, simulations and computational modelling identified the rolling mechanism, closely followed by sliding, as the main mechanisms of particle detachment.…”

Section: Adhesion Measurementsmentioning

confidence: 99%

Characterisation of dry powder inhaler formulations using atomic force microscopy

Weiss

McLoughlin

Cathcart

2015

International Journal of Pharmaceutics

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A B S T R A C TInhalation formulations are a popular way of treating the symptoms of respiratory diseases. The active pharmaceutical ingredient (API) is delivered directly to the site of action within the deep lung using an inhalation device such as the dry powder inhaler (DPI).The performance of the formulation and the efficiency of the treatment depend on a number of factors including the forces acting between the components. In DPI formulations these forces are dominated by interparticulate interactions. Research has shown that adhesive and cohesive forces depend on a number of particulate properties such as size, surface roughness, crystallinity, surface energetics and combinations of these. With traditional methods the impact of particulate properties on interparticulate forces could be evaluated by examining the bulk properties. Atomic force microscopy (AFM), however, enables the determination of local surface characteristics and the direct measurement of interparticulate forces using the colloidal probe technique. AFM is considered extremely useful for evaluating the surface topography of a substrate (an API or carrier particle) and even allows the identification of crystal faces, defects and polymorphs from high-resolution images. Additionally, information is given about local mechanical properties of the particles and changes in surface composition and energetics. The assessment of attractive forces between two bodies is possible by using colloidal probe AFM.This review article summarises the application of AFM in DPI formulations while specifically focussing on the colloidal probe technique and the evaluation of interparticulate forces.2015 Elsevier B.V. All rights reserved.

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Surface roughness effects on the tribo-charging and mixing homogeneity of adhesive mixtures used in dry powder inhalers

Cited by 21 publications

References 15 publications

Experimental and numerical study of wall layer development in a tribocharged fluidized bed

Experimental and numerical study of wall layer development in a tribocharged fluidized bed

Combined control of morphology and polymorph in spray drying of mannitol for dry powder inhalation

Characterisation of dry powder inhaler formulations using atomic force microscopy

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