Surface properties of fullerenol C60(OH)20 solutions

Akentiev, Alexander V.; Gorniaia, Sofiia B.; Isakov, N. A.; Lebedev, Vasylij T.; Milyaeva, O.Yu.; Sedov, V. P.; Semenov, Konstantin N.; Timoshen, Kirill A.; Noskov, Boris A.

doi:10.1016/j.molliq.2020.112904

Cited by 15 publications

(11 citation statements)

References 30 publications

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“…The particles’ distribution of FNPs was measured using dynamic light scattering (DLS) and Z potential, as presented in Figure S1. Many pieces of literature reported that fullerenol is easy to aggregate in an aqueous solution. − Using the DLS to detect the FNPs in solution, the bigger size of these FNPs than in the AFM image suggested the occurrence of aggregation in the aqueous solution. Using a transmission electron microscope, FNPs with different isoelectric points were detected in our laboratory, as stated in another article .…”

Section: Resultsmentioning

confidence: 99%

Fullerenol Nanoparticles Eradicate Helicobacter pylori via pH-Responsive Peroxidase Activity

Zhang

Chen

Kong

et al. 2020

ACS Appl. Mater. Interfaces

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Helicobacter pylori (H. pylori) eradication by antibiotics and proton pump inhibitor treatment is limited by the low pH microenvironment in the stomach and can lead to antibiotic resistance. We fabricated fullerenol nanoparticles (FNPs) with varied chemical structures responding to a pinacol rearrangement of vicinal hydroxyl to form carbonyls in low pH environments. An obvious increase in CO/C−O was induced in low pH and was positively correlated with a peroxidase-like activity. The FNPs exerted an excellent effect on H. pylori eradication in vitro and in vivo because of their peroxidase-like activity. FNP treatment of a H. pylori biofilm revealed that FNPs broke down polysaccharides in cell wall components, resulting in collapse of the bacteria. The cycles of FNPs combining and dissociating with the peroxidase substrate were detected by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and confirmed that FNPs enhance peroxidase-like activity. Further, the isothermal titration calorimetry results showed that FNPs with more CO/C−O had greater affinity to bind the peroxidase substrates. Therefore, we suggest that varied CO/ C−O serves as a switch to respond to low pH in the stomach to kill H. pylori by inducing a peroxidase-like activity. FNPs can also overcome the challenge of antibiotic resistance to achieve H. pylori eradication in the stomach.

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Section: Resultsmentioning

confidence: 99%

Fullerenol Nanoparticles Eradicate Helicobacter pylori via pH-Responsive Peroxidase Activity

Zhang

Chen

Kong

et al. 2020

ACS Appl. Mater. Interfaces

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“…The incident angle was set at 75° with the thickness set to fit. Once Ψ and Δ were obtained, the complex reflectance ratio (ρ) was determined by using eq and then used to derive the optical constants (i.e., film thickness) of lipid films at the air–water interface. − Specifically, SE was used to monitor changes to DPPC monolayer thickness with the inclusion of PHFs to both 55 and 40 Å 2 /molecule deposited DPPC. Monolayer thicknesses reported from SE experiments are the average of six measurements taken per sample.…”

Section: Methodsmentioning

confidence: 99%

Carbon Nanoparticle-Induced Changes to Lipid Monolayer Structure at Water–Air Interfaces

et al. 2022

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Surface specific vibrational spectroscopy experiments together with surface tension measurements and spectroscopic ellipsometry data were used to characterize the effects of soluble carbon particulates on compressed and partially compressed lipid monolayers adsorbed to the water–air interface. The lipid monolayers consisted of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DPPC), and measurements were made for both tightly packed monolayers (40 Å2/molecule) and monolayers in their liquid condensed state (55 Å2/molecule). Langmuir trough data show that very small amounts of PHF (0.0075 mg/mL or 6.4 × 10–6 M) decrease lipid film compressibility. This finding supports a cooperative adsorption mechanism whereby the soluble PHFs are drawn to the surface and associate with the insoluble DPPC monolayer. Excess free energies (ΔG mix E) were positive, consistent with the cooperative adsorption mechanism, and although the excess free energies are small (≤1 kJ/mol), adsorbed PHF has measurable effects on monolayer structure. Further support for the cooperative adsorption mechanism at the water–air interface comes from vibrational sum frequency generation (VSFG) experiments. Low PHF concentrations (≤0.06 mg/mL) increase DPPC acyl chain ordering in liquid condensed lipid films and decrease DPPC acyl chain ordering and film thickness in tightly packed lipid films.

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“…Like other carbon nanostructures, fullerenes are not toxic to the human body [12][13][14]. The doping of fullerenes results in a wide family of derivative compounds, which possess a wide variety of physical and chemical characteristics, including adsorption properties, electronic structure and solubility [15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Ab Initio Insight into the Interaction of Metal-Decorated Fluorinated Carbon Fullerenes with Anti-COVID Drugs

Katin

Kochaev

El-Hajjaji

et al. 2022

IJMS

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We theoretically investigated the adsorption of two common anti-COVID drugs, favipiravir and chloroquine, on fluorinated C60 fullerene, decorated with metal ions Cr3+, Fe2+, Fe3+, Ni2+. We focused on the effect of fluoridation on the interaction of fullerene with metal ions and drugs in an aqueous solution. We considered three model systems, C60, C60F2 and C60F48, and represented pristine, low-fluorinated and high-fluorinated fullerenes, respectively. Adsorption energies, deformation of fullerene and drug molecules, frontier molecular orbitals and vibrational spectra were investigated in detail. We found that different drugs and different ions interacted differently with fluorinated fullerenes. Cr3+ and Fe2+ ions lead to the defluorination of low-fluorinated fullerenes. Favipiravir also leads to their defluorination with the formation of HF molecules. Therefore, fluorinated fullerenes are not suitable for the delivery of favipiravir and similar drugs molecules. In contrast, we found that fluorine enhances the adsorption of Ni2+ and Fe3+ ions on fullerene and their activity to chloroquine. Ni2+-decorated fluorinated fullerenes were found to be stable and suitable carriers for the loading of chloroquine. Clear shifts of infrared, ultraviolet and visible spectra can provide control over the loading of chloroquine on Ni2+-doped fluorinated fullerenes.

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Surface properties of fullerenol C60(OH)20 solutions

Cited by 15 publications

References 30 publications

Fullerenol Nanoparticles Eradicate Helicobacter pylori via pH-Responsive Peroxidase Activity

Fullerenol Nanoparticles Eradicate Helicobacter pylori via pH-Responsive Peroxidase Activity

Carbon Nanoparticle-Induced Changes to Lipid Monolayer Structure at Water–Air Interfaces

Ab Initio Insight into the Interaction of Metal-Decorated Fluorinated Carbon Fullerenes with Anti-COVID Drugs

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