Leading photovoltaic technologies such as multicrystalline Si, CdTe, Cu(In,Ga)Se 2 and lead halide perovskites are polycrystalline, yet achieve relatively high performance. At the moment polycrystalline photovoltaic technologies stand at a juncture where further advances in device performance and reliability necessitate additional characterization and modelling to include nanoscale property variations. Properties and implications of grain boundaries have been previously studied, yet chemistry variations along individual grain boundaries and its implications have not yet been fully explored. Here, we report on the effects of bromine etching of CdTe absorber layers on the nanoscale chemistry. Bromine etching is commonly used for improving CdTe back contacts, yet we report it removes both cadmium and chlorine along grain boundaries to depths closer to 1µm. Two dimensional device simulations reveal these composition modifications limit photovoltaic performance. Since grain boundaries and their intersections with surfaces and interfaces are universal to thin film photovoltaics, these findings call for similar studies in each of the photovoltaic technologies to further enable advances.Received: ((will be filled in by the editorial staff))Revised: ((will be filled in by the editorial staff))