Surface plasmon resonance study of the actin-myosin sarcomeric complex and tubulin dimers

Schuessler, H. A.; Mershin, Andreas; Kolomenskii, Alexander; Nanopoulos, Dimitri V.

doi:10.1080/0950034032000120885

Cited by 2 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In order to experimentally determine the dipole moment of tubulin, Mershin et al 30 and Schuessler et al 31 performed a surface plasmon resonance study on tubulin dimers in solution. Analysis of their data yielded for tubulin a refractive index n = 2 9 and a dielectric constant =n 2 = 8 4 and p ≈ 1000 debye.…”

Section: Possible Ferroelectricity Of Microtubulesmentioning

confidence: 99%

Bio-Ferroelectricity at the Nanoscale

Tuszyński¹,

Craddock²,

Carpenter³

2008

Jnl of Comp & Theo Nano

View full text Add to dashboard Cite

This article discusses the dielectric properties of several biomolecules and biomolecular assemblies, especially PVDF, tubulin and microtubules as well as voltage-gated ion channels. The emphasis in this paper is placed on identifying the potential for the occurrence of bio-ferroelectricity and its role in biological functions, in particular self-assembly and control of mass and charge transport. Detailed discussion is given on the experimental and theoretical estimates of the value of the dielectric constant of tubulin as a crucial quantity defining both ferroelectric and conductive properties of microtubules. A critical need is stated for experimental data at the level of individual nano-scale components forming biological structures.

show abstract

Section: Possible Ferroelectricity Of Microtubulesmentioning

confidence: 99%

Bio-Ferroelectricity at the Nanoscale

Tuszyński¹,

Craddock²,

Carpenter³

2008

Jnl of Comp & Theo Nano

View full text Add to dashboard Cite

show abstract

“…Tuszyński et al [16,19] have recently recalculated the values of the dipole moments and net charges using the sequences of the various homologous isotypes of tubulin. In order to experimentally determine the dipole moment of tubulin, Mershin et al [20] and Schuessler et al [21] performed a surface plasmon resonance study on tubulin dimers in solution. Analysis of their data yielded for tubulin a refractive index n = 2.9 and hence a dielectric constant eð¼ n 2 Þ ¼ 8:4 and p j j % 1; 000 Debye which agrees with the order of magnitude of the calculated dipole moment.…”

Section: Ferroelectric Properties Of Microtubulesmentioning

confidence: 99%

Modelling the Role of Intrinsic Electric Fields in Microtubules as an Additional Control Mechanism of Bi-directional Intracellular Transport

Satarić

Budinski-Petković

Lončarević

et al. 2008

Cell Biochem Biophys

View full text Add to dashboard Cite

Active transport is essential for cellular function, while impaired transport has been linked to diseases such as neuronal degeneration. Much long distance transport in cells uses opposite polarity molecular motors of the kinesin and dynein families to move cargos along microtubules. It is clear that many types of cargo are moved by both sets of motors, and frequently in a reverse direction. The general question of how the direction of transport is regulated is still open. The mechanism of the cell's differential control of diverse cargos within the same cytoplasmic background is still unclear as is the answer to the question how endosomes and mitochondria move to different locations within the same cell. To answer these questions we postulate the existence of a local signaling mechanism used by the cell to specifically control different cargos. In particular, we propose an additional physical mechanism that works through the use of constant and alternating intrinsic (endogenous) electric fields as a means of controlling the speed and direction of microtubule-based transport. A specific model is proposed and analyzed in this paper. The model involves the rotational degrees of freedom of the C-termini of tubulin, their interactions and the coupling between elastic and dielectric degrees of freedom. Viscosity of the solution is also included and the resultant equation of motion is found as a nonlinear elliptic equation with dissipation. A particular analytical solution of this equation is obtained in the form of a kink whose properties are analyzed. It is concluded that this solution can be modulated by the presence of electric fields and hence may correspond to the observed behavior of motor protein transport along microtubules.

show abstract

Surface plasmon resonance study of the actin-myosin sarcomeric complex and tubulin dimers

Cited by 2 publications

References 0 publications

Bio-Ferroelectricity at the Nanoscale

Bio-Ferroelectricity at the Nanoscale

Modelling the Role of Intrinsic Electric Fields in Microtubules as an Additional Control Mechanism of Bi-directional Intracellular Transport

Contact Info

Product

Resources

About