Surface Plasmon Resonance Study of the Binding of PEO–PPO–PEO Triblock Copolymer and PEO Homopolymer to Supported Lipid Bilayers

Kim, Mihee; Vala, Milan; Ertsgaard, Christopher T.; Oh, Sang Hyun; Lodge, Timothy P.; Bates, Frank S.; Hackel, Benjamin J.

doi:10.1021/acs.langmuir.8b00873

Cited by 17 publications

(40 citation statements)

References 75 publications

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“…It has been established that block copolymer molecular design impacts molecular interaction with phospholipid membranes and this, in turn, significantly affects muscle membrane stabilization efficacy 50, 51, 52, 53, 139. From a structure-function perspective, there is a significant opportunity to gain mechanistic insights with the long-range goal to improve and optimize membrane stabilization properties of block copolymers (Table 1).…”

Section: The Copolymer-membrane Interface: Toward the Mechanism Of Mumentioning

confidence: 99%

Cardiac Muscle Membrane Stabilization in Myocardial Reperfusion Injury

Houang

Bartos

Hackel

et al. 2019

JACC: Basic to Translational Science

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Highlights In myocardial ischemia, the integrity of the cardiac sarcolemma is severely stressed in the critical earliest moments upon reperfusion. Bolstering sarcolemma integrity improves myocyte survival. This review focuses on cardiac sarcolemma stability and its role as a therapeutic target in ischemia-reperfusion injury. Synthetic block copolymers have been shown to interface with the muscle membrane to confer membrane stabilization during stress. Integrated multidisciplinary research teams, spanning cardiology, physiology, chemistry, and chemical engineering are essential to guide future mechanistic and translational studies of novel chemical-based membrane stabilizers for preserving viable heart muscle during ischemia-reperfusion injury in human patients.

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Section: The Copolymer-membrane Interface: Toward the Mechanism Of Mumentioning

confidence: 99%

Cardiac Muscle Membrane Stabilization in Myocardial Reperfusion Injury

Houang

Bartos

Hackel

et al. 2019

JACC: Basic to Translational Science

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“…The immobilization can be performed directly on the hard support, as in the case of cyclodextrin‐based polymersomes covered by a biotin functional poly(acrylic acid), which is bonded on a streptavidin surface . More common are the interactions of polymersomes with a soft functional surface composed of amphiphilic polymers or lipids . In general, an amphiphilic bilayer is spread on a solid support, and the heads of the lipids are functionalized with an active molecule which acts as the recognition site .…”

Section: Planar Membrane Fabricationmentioning

confidence: 99%

“…More common are the interactions of polymersomes with a soft functional surface composed of amphiphilic polymers or lipids . In general, an amphiphilic bilayer is spread on a solid support, and the heads of the lipids are functionalized with an active molecule which acts as the recognition site . Alternatively, molecular anchors can be employed, like cholesterol or aliphatic chains .…”

Section: Planar Membrane Fabricationmentioning

confidence: 99%

Self‐Assembled Polymeric Membranes and Nanoassemblies on Surfaces: Preparation, Characterization, and Current Applications

Chimisso

Maffeis

Hürlimann

et al. 2019

Macromolecular Bioscience

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Biomembranes play a crucial role in a multitude of biological processes, where high selectivity and efficiency are key points in the reaction course. The outstanding performance of biological membranes is based on the coupling between the membrane and biomolecules, such as membrane proteins. Polymer‐based membranes and assemblies represent a great alternative to lipid ones, as their presence not only dramatically increases the mechanical stability of such systems, but also opens the scope to a broad range of chemical functionalities, which can be fine‐tuned to selectively combine with a specific biomolecule. Tethering the membranes or nanoassemblies on a solid support opens the way to a class of functional surfaces finding application as sensors, biocomputing systems, molecular recognition, and filtration membranes. Herein, the design, physical assembly, and biomolecule attachment/insertion on/within solid‐supported polymeric membranes and nanoassemblies are presented in detail with relevant examples. Furthermore, the models and applications for these materials are highlighted with the recent advances in each field.

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“…Moreover, this study provides biophysical evidence that copolymer adsorption alone does not fully account for membrane protection efficacy. [ 172 ] A schematic summary of structure-function of copolymer-based membrane stabilization is presented in (Fig. 4 ) .…”

Section: Copolymer Structure-function Analysismentioning

confidence: 99%

Muscle membrane integrity in Duchenne muscular dystrophy: recent advances in copolymer-based muscle membrane stabilizers

et al. 2018

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The scientific premise, design, and structure-function analysis of chemical-based muscle membrane stabilizing block copolymers are reviewed here for applications in striated muscle membrane injury. Synthetic block copolymers have a rich history and wide array of applications from industry to biology. Potential for discovery is enabled by a large chemical space for block copolymers, including modifications in block copolymer mass, composition, and molecular architecture. Collectively, this presents an impressive chemical landscape to leverage distinct structure-function outcomes. Of particular relevance to biology and medicine, stabilization of damaged phospholipid membranes using amphiphilic block copolymers, classified as poloxamers or pluronics, has been the subject of increasing scientific inquiry. This review focuses on implementing block copolymers to protect fragile muscle membranes against mechanical stress. The review highlights interventions in Duchenne muscular dystrophy, a fatal disease of progressive muscle deterioration owing to marked instability of the striated muscle membrane. Biophysical and chemical engineering advances are presented that delineate and expand upon current understanding of copolymer-lipid membrane interactions and the mechanism of stabilization. The studies presented here serve to underscore the utility of copolymer discovery leading toward the therapeutic application of block copolymers in Duchenne muscular dystrophy and potentially other biomedical applications in which membrane integrity is compromised.

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Surface Plasmon Resonance Study of the Binding of PEO–PPO–PEO Triblock Copolymer and PEO Homopolymer to Supported Lipid Bilayers

Cited by 17 publications

References 75 publications

Cardiac Muscle Membrane Stabilization in Myocardial Reperfusion Injury

Cardiac Muscle Membrane Stabilization in Myocardial Reperfusion Injury

Self‐Assembled Polymeric Membranes and Nanoassemblies on Surfaces: Preparation, Characterization, and Current Applications

Muscle membrane integrity in Duchenne muscular dystrophy: recent advances in copolymer-based muscle membrane stabilizers

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