Surface plasmon resonance prism coupler for enhanced circular birefringence sensing and application to non-invasive glucose detection

Abstract

A surface plasmon resonance (SPR) prism coupler is proposed for the high-resolution non-invasive (NI) measurement of the circular birefringence (CB) properties of turbid media. The feasibility of the proposed device is demonstrated by means of numerical simulations. It is shown that the SPR sensor enables the CB properties to be detected with a resolution of up to 8.9 × 10−7 RIU (refractive index units) for refractive indices in the range of 1.3∼1.4. Moreover, for tissue phantom solutions containing 2% lipofundin, the device has a detection limit of 3.72 mg/dL. This resolution performance satisfies the detection limit of 10 mg/dL stipulated by the U.S FDA for point-of-care glucose monitoring devices. Thus, the proposed SPR sensor has significant potential for NI glucose sensing in such applications as diabetes detection and management.

Dual-Retarder Mueller Polarimetry System for Extraction of Optical Properties of Serum Albumin Protein Media

“…Furthermore, the time taken for one circle of scanning was set equal to 3 s, and the measured results of the Mueller matrix of air, the half-wave plate, and mirror are shown in Table 2 . As shown, the elements of the air matrix had a maximum error of just 10 −3 , and for the half-wave plate and mirror, the matrix elements had a maximum error of 10 −2 , comparable with the accuracy and speed of the EO system proposed in [ 31 , 32 ]. Notably, the cost of the LCVR system is four times lower than that of the EO system.…”

“…The second LCVR was adjusted to the principal angle of 45°, and the phase retardances of the two LCVRs were set as Table 1 to generate three linear polarization lights (0°, 45°, and 90°) and one circular polarization light (right-hand). We should note that the calibration process for the LCVR system is much easier than that of the EO system proposed in [ 31 , 32 ]. Furthermore, the time taken for one circle of scanning was set equal to 3 s, and the measured results of the Mueller matrix of air, the half-wave plate, and mirror are shown in Table 2 .…”

“…Han et al [ 30 ] proposed a rapid full Mueller imaging polarimetry system based on LCVRs for extracting the Mueller matrix of shrimp shells under heating treatment. In previous studies [ 31 , 32 ], the present group proposed an enhanced Mueller polarimetry system for NI glucose concentration measurement incorporating two EO modulators and a SPR prism coupler. However, the proposed system is expensive and requires a complicated calibration of the EO components.…”

A Nanoscale Structure Based on an MIM Waveguide Coupled with a Q Resonator for Monitoring Trace Element Concentration in the Human Body

“…The input end of a biosensor based on the structure designed here would be connected with nano fiber to provide a channel for incident light, and its output would be connected with JY Confocal Raman Microscopy, which would be used to detect an output signal [32]. The biosensor could be used for human health monitoring, such as glucose concentration detection [33], temperature monitoring [34][35][36], and hemoglobin detection [37,38]. Trace elements are also essential for the human body; the structure we designed could be used to detect the content of Na + in our body.…”

Microstructured Optical Fiber Based on Surface Plasmon Resonance for Dual-Optofluidic-Channel Sensing

“…To excite SPR, there are few nanomaterials placed on a dielectric substrate to achieve the interaction of light and free electrons, such as gold and silver. Up to now, several SPR devices have been proposed including prism-coupled microfluidic systems [6][7][8][9][10], metal-coated fiber-optic sensors [11][12][13], gold-integrated MOF sensors [14,15], graphene-based plasmonic chip [16], and antimonene-based sensor [17], etc. These SPR-based devices possess the advantages of high performance, which makes them a promising tool for the optical detection.…”