Surface Plasmon Resonance Imaging Measurements of Ultrathin Organic Films

Brockman, Jennifer M.; Nelson, Bryce P.; Corn, Robert M.

doi:10.1146/annurev.physchem.51.1.41

Cited by 510 publications

(357 citation statements)

References 85 publications

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“…Angular dependent intensities of SPCECL (bottom). The upper panel shows the reflectivity of the gold film calculated using a gold dielectric constant of ε m = −10.5 + 1.49i and the software from [23,24] and http://corninfo.chem.wisc.edu Emission spectra of [Ru(bpy) 3 ] 2+ (top) and of SPCECL in acetonitrile (bottom).…”

Section: Discussionmentioning

confidence: 99%

First observation of surface plasmon-coupled electrochemiluminescence

Zhang

Gryczyński

Lakowicz

2004

Chemical Physics Letters

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Section: Discussionmentioning

confidence: 99%

First observation of surface plasmon-coupled electrochemiluminescence

Zhang

Gryczyński

Lakowicz

2004

Chemical Physics Letters

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“…This method is label free, in situ, surface sensitive, measures in realtime and, by measuring the light source with a microscope or camera, spatially resolved measurements can be made using a method termed surface plasmon resonance imaging [76][77][78]. This approach has been applied to the study of protein-material interactions on a microarray format [79].…”

Section: Assessment Of Biological Response To Microarraysmentioning

confidence: 99%

High throughput methods applied in biomaterial development and discovery

et al. 2010

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The high throughput discovery of new materials can be achieved by rapidly screening many different materials synthesised by a combinatorial approach to identify the optimal material that fulfils a particular biomedical application. Here we review the literature in this area and conclude that for polymers, this process is best achieved in a microarray format, which enable thousands of cell-material interactions to be monitored on a single chip. Polymer microarrays can be formed by printing pre-synthesised polymers or by printing monomers onto the chip where on-slide polymerisation is initiated.The surface properties of the material can be analysed and correlated to the biological performance using high throughput surface analysis, including time-of-flight secondary ion mass spectrometry (ToF-SIMS), Xray photoelectron spectroscopy (XPS) and water contact angle (WCA) measurements. This approach enables the surface properties responsible for the success of a material to be understood, which in turn provides the foundations of future material design. The high throughput discovery of materials using polymer microarrays has been explored for many cell-based applications including the isolation of specific 2 cells from heterogeneous populations, the attachment and differentiation of stem cells and the controlled transfection of cells.Further development of polymerisation techniques and high throughput biological assays amenable to the polymer microarray format will broaden the combinatorial space and biological phenomenon that polymer microarrays can explore, and increase their efficacy. This will, in turn, result in the discovery of optimised polymeric materials for many biomaterial applications.

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“…This sensor detects changes in the refractive index induced by molecules near the surface of noble metal thin films. 99,100 Riboh et al 101 demonstrated LSPR nanobiosensor study on the prototypical immunoassay involving biotin (B) and anti-biotin (AB). The optical biosensors detect change in local refractive index by monitoring the LSPR extinction maximum with UV-Visible spectroscopy.…”

Section: Immunoassay (Detection Of Ab-ag Reaction)mentioning

confidence: 99%

Biomedical applications of nanobiosensors: the state-of-the-art

Rai¹,

Gade²,

Gaikwad³

et al. 2012

J. Braz. Chem. Soc.

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O desenvolvimento de nanobiosensores é um dos avanços mais recentes no campo da nanotecnologia. A investigação sobre nanobiosensores ópticos com dimensões submicrométricas tem aberto novos horizontes para as medições intracelulares. Aproveitando as propriedades únicas dos nanomateriais, nanobiosensores mais rápidos e sensíveis podem ser desenvolvidos. Além de serem sensíveis e rápidos, os estudos de nanobiosensores têm voltado seus esforços para o desenvolvimento de sensores baseados em nanomateriais que são acessíveis, robustos e reprodutíveis. Os nanobiosensores estão equipados com sondas biorreceptoras imobilizadas, por exemplo, anticorpos, substrato de enzima. A excitação por laser é transmitida para o sistema fotométrico na forma de sinal óptico (fluorescência). Os nanobiosessores poderão revolucionar no futuro o diagnóstico de doenças. A presente revisão discute os conceitos básicos, a evolução e as aplicações biomédicas de nanobiosensores.Development of nanobiosensor is one of the most recent advancement in the field of Nanotechnology. Research on optical nanobiosensors with submicron-sized dimensions has opened new horizons for intracellular measurements. Taking advantage of the unique properties of the nanomaterials, faster and sensitive nanobiosensors can be developed. Apart from being sensitive and fast, the studies related to nanobiosensors have geared their efforts towards the development of nanomaterial-based sensors that are affordable, robust and reproducible. The nanobiosensors are equipped with immobilized bioreceptor probes, e.g., antibodies, enzyme substrate. Laser excitation is transmitted to photometric system in the form of optical signal (fluorescence). Nanobiosensors will revolutionize the future of disease diagnosis. The present review discusses the basic concepts, developments and the biomedical applications of nanobiosensors.

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Surface Plasmon Resonance Imaging Measurements of Ultrathin Organic Films

Cited by 510 publications

References 85 publications

First observation of surface plasmon-coupled electrochemiluminescence

First observation of surface plasmon-coupled electrochemiluminescence

High throughput methods applied in biomaterial development and discovery

Biomedical applications of nanobiosensors: the state-of-the-art

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