Surface plasmon resonance imaging as a multidimensional surface characterization instrument—Application to biochip genotyping

Lecaruyer, Pierre; Mannelli, Ilaria; Courtois, Virginie; Goossens, Michel; Canva, Michael

doi:10.1016/j.aca.2006.03.003

Cited by 21 publications

(16 citation statements)

References 18 publications

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“…In addition to these two parameters (θ; ω), the signal depends on the twospace dimensions (x; y), time (t), and on the light polarization. This multidimensional aspect of the new generation of SPR sensors was presented in previous works [17].…”

Section: B Plasmon Theorymentioning

confidence: 79%

Absorption and related optical dispersion effects on the spectral response of a surface plasmon resonance sensor

et al. 2008

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Surface plasmon resonance (SPR) sensing is an optical technique that allows real time detection of small changes in the physical properties, in particular in the refractive index, of a dielectric medium near a metal film surface. One way to increase the SPR signal shift is then to incorporate a substance possessing a strong dispersive refractive index in the range of the plasmon resonance band. In this paper, we investigate the impact of materials possessing a strong dispersive index integrated to the dielectric medium on the SPR reflectivity profile. We present theoretical results based on chromophore absorption spectra and on their associated refractive index obtained from the Lorentz approach and Kramers-Krönig equations. As predicted by the theory, the experimental results show an enhancement of the SPR response, maximized when the chromophore absorption band coincides with the plasmon resonant wavelength. This shows that chromophores labeling can provide a potential way for SPR response enhancement.

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Section: B Plasmon Theorymentioning

confidence: 79%

Absorption and related optical dispersion effects on the spectral response of a surface plasmon resonance sensor

et al. 2008

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“…The detection of point mutations has also been examined, such as in studies of the detection of the mutations associated with cystic fi brosis (Lecaruyer et al , 2006). Other workers have also developed an elegant method for distinguishing single nucleotide polymorphisms (Fiche et al , 2008).…”

Section: Spr Biosensors and Spr Imagingmentioning

confidence: 99%

Biosensors for DNA and RNA detection and characterization

Davis

Higson

2012

Biosensors for Medical Applications

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“…In particular, SPR was used as a tool for the detection of point mutation related to tumor suppressor genes (e.g., TP53 [90][91][92][93] and K-Ras [94]), cancer disease [95,96], and hereditary disease [97][98][99][100][101][102].…”

Section: Point Mutation Detectionmentioning

confidence: 99%

Surface plasmon resonance applications in clinical analysis

2014

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In the last 20 years, surface plasmon resonance (SPR) and its advancement with imaging (SPRi) emerged as a suitable and reliable platform in clinical analysis for label-free, sensitive, and real-time monitoring of biomolecular interactions. Thus, we report in this review the state of the art of clinical target detection with SPR-based biosensors in complex matrices (e.g., serum, saliva, blood, and urine) as well as in standard solution when innovative approaches or advanced instrumentations were employed for improved detection. The principles of SPR-based biosensors are summarized first, focusing on the physical properties of the transducer, on the assays design, on the immobilization chemistry, and on new trends for implementing system analytical performances (e.g., coupling with nanoparticles (NPs). Then we critically review the detection of analytes of interest in molecular diagnostics, such as hormones (relevant also for anti-doping control) and biomarkers of interest in inflammatory, cancer, and heart failure diseases. Antibody detection is reported in relation to immune disorder diagnostics. Subsequently, nucleic acid targets are considered for revealing genetic diseases (e.g., point mutation and single nucleotides polymorphism, SNPs) as well as new emerging clinical markers (microRNA) and for pathogen detection. Finally, examples of pathogen detection by immunosensing were also analyzed. A parallel comparison with the reference methods was duly made, indicating the progress brought about by SPR technologies in clinical routine analysis.

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Surface plasmon resonance imaging as a multidimensional surface characterization instrument—Application to biochip genotyping

Cited by 21 publications

References 18 publications

Absorption and related optical dispersion effects on the spectral response of a surface plasmon resonance sensor

Absorption and related optical dispersion effects on the spectral response of a surface plasmon resonance sensor

Biosensors for DNA and RNA detection and characterization

Surface plasmon resonance applications in clinical analysis

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