Surface pH buffering to promote degradation of mesoporous silica nanoparticles under a physiological condition

Choi, E.; Kim, Sehoon

doi:10.1016/j.jcis.2018.08.088

Cited by 50 publications

(36 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In order to solve these problems, some novel mesoporous silica nanoparticles with rapid degradation rate have been synthesized. Zhao's group 175 developed uniform monodispersed three-dimensional dendritic mesoporous silica nanospheres with rapid simulated biodegradation, which were completely eliminated within 24 h. Choi and Kim 176 promoted the degradation of MSNs in a physiological condition by surface coating of polyethyleneimine (PEI) based on its proton-sponge effect. Efforts have been made to fabricate multi-stimuli responsive surfaces on MSN for environmentally sensitive, site-specific drug delivery with rapid degradation 159 .…”

Section: Inorganic Materials For Drug Deliverymentioning

confidence: 99%

Recent progress in drug delivery

Wang

et al. 2019

Acta Pharmaceutica Sinica B

597

272

View full text Add to dashboard Cite

Drug delivery systems (DDS) are defined as methods by which drugs are delivered to desired tissues, organs, cells and subcellular organs for drug release and absorption through a variety of drug carriers. Its usual purpose to improve the pharmacological activities of therapeutic drugs and to overcome problems such as limited solubility, drug aggregation, low bioavailability, poor biodistribution, lack of selectivity, or to reduce the side effects of therapeutic drugs. During 2015–2018, significant progress in the research on drug delivery systems has been achieved along with advances in related fields, such as pharmaceutical sciences, material sciences and biomedical sciences. This review provides a concise overview of current progress in this research area through its focus on the delivery strategies, construction techniques and specific examples. It is a valuable reference for pharmaceutical scientists who want to learn more about the design of drug delivery systems.

show abstract

Section: Inorganic Materials For Drug Deliverymentioning

confidence: 99%

Recent progress in drug delivery

Wang

et al. 2019

Acta Pharmaceutica Sinica B

597

272

View full text Add to dashboard Cite

show abstract

“…These same conditions also favour siloxane bond (Si-O-Si) hydrolysis, facilitating silica dissolution 36 . Adsorption of PEI to silica further promotes silica dissolution at neutral and acidic pH due to pH buffering 37 . Our data show that DC activation in response to the vaccine is associated with the induction of tumour-specific adaptive immunity and protection against secondary tumour challenge.…”

Section: Nature Biomedical Engineeringmentioning

confidence: 99%

Cancer vaccines from cryogenically silicified tumour cells functionalized with pathogen-associated molecular patterns

et al. 2021

View full text Add to dashboard Cite

“…Although mesoporous silica has a high drug loading rate and can control the release rate of drug, the liver, kidney and other organs will non-specifically take the drug and cause systemic toxicity before the released drug reaches the target site. Therefore, researchers employ activatable functionalization concept to address this issue and mesoporous silica with the ability of stimuli-responsive drug release such as pH-responsive, [52][53][54][55] temperature-responsive, 56 redox-responsive, [57][58][59][60] enzymeresponsive, 61,62 magnetic-responsive, [63][64][65] and jointstimulus-responsive 66,67 have been well developed. However, it should be mentioned that up to now, most of them were all designed for the diagnosis and treatment of tumor.…”

Section: Surface Modification and Functionalization Of Mesoporous Silicamentioning

confidence: 99%

The Opportunities and Challenges of Silica Nanomaterial for Atherosclerosis

Sha¹,

Dai²,

Song³

et al. 2021

IJN

View full text Add to dashboard Cite

Atherosclerosis (AS) as the leading cause of cardiovascular and cerebrovascular events has been paid much attention all the time. With the continuous development of modern medical drug treatment, surgical treatment, interventional treatment and other methods, the mortality rate of AS has shown a downward trend, while the morbidity rate is still increasing. Oral lipid-lowering or anti-inflammatory drugs are generally used for early AS, but the relatively low accumulation efficiency in lesions and the unavoidable side effects required researchers to develop more effective drug delivery approaches for the therapy of AS. Mesoporous silica nanoparticles as nanocarrier for drug delivery have received extensive attentions due to their flexible size, high specific surface area, controlled pore volume, high drug loading capacity and excellent biocompatibility. Series of good reviews about the mesoporous silica nanoparticles loaded drugs for cancer therapy have been well documented. However, their roles as nanocarrier for drug delivery to treat AS have few reports. In this review, the applications and challenges of mesoporous silica nanomaterials in the field of the diagnosis and therapy of AS have been summarized. The classification, synthesis, formation mechanism, surface modification and functionalization of mesoporous silica nanomaterials which were closely related to the theranostic effect of AS have also been included. Last but not the least, the future prospects’ suggestions of mesoporous silica nanomaterial-based drug delivery system for AS are also provided.

show abstract

Surface pH buffering to promote degradation of mesoporous silica nanoparticles under a physiological condition

Cited by 50 publications

References 30 publications

Recent progress in drug delivery

Recent progress in drug delivery

Cancer vaccines from cryogenically silicified tumour cells functionalized with pathogen-associated molecular patterns

The Opportunities and Challenges of Silica Nanomaterial for Atherosclerosis

Contact Info

Product

Resources

About