Surface parameters modification by multilayer coatings deposition for biomedical applications

Experimental therapy of graft-versus-host disease by mesenchymal stromal cells grown on oxide nanocoatings

“…Experiments in fibroblasts and macrophages grown on the matrix carriers (titanium and its alloys, niobium, stainless steel, polymers) showed an important role of material surface peculiarities (relief, hydrophobic and hydrophilic characteristics, chemical composition) which determine structural and functional characteristics of the cells [23]. Some researches were focused on the effect of a surface energy of different coatings, its dispersion and polar features rendered on cell cultures [24]. For example, high surface energy and coatings' fractional polarity were demonstrated to stimulate a fibroblast proliferation.…”

Corrosion properties of nitride, oxide and multilayer coatings on stainless steel and titanium-based substrates

“…The best mechanical parameters were obtained in the case of nitride coatings on both SS and Ti substrates and for multilayer nitride/oxide coatings [9]. The anodic polarization corrosion tests using the potentiodynamic technique in the potential range 1.0 V -+2.0 V at a scanning rate of 1 mV/s are presented in figure 1 a) The Nyquist impedance plot was obtained from the real (Z re = R s +R p /(1+ω 2 R p 2 C d 2 )) and the imaginary (Z im = ωR p 2 C d /(1+ω 2 R p 2 C d 2 )) impedance at different frequencies to determine the chargetransfer kinetics (R s is the electrolyte solution resistance, R p is the polarization resistance and C d is the capacitance at the interface).…”

“…The TiN coatings were deposited by means of Arc-PVD. The main parameters of the process were described in our previous study [7,8]: reactive atmosphere N 2 , deposition pressure 8 10 -2 Pa, arc current 100 A, substrate bias -150 V, deposition temperature 593 o K, thickness of deposited coatings 2 -5 μm. TiN (MS), Al 2 O 3 (MS) and multilayer coating deposition were performed in a high-vacuum pumping system with base pressure about 10 -5 mBar.…”

“…TiN (MS), Al 2 O 3 (MS) and multilayer coating deposition were performed in a high-vacuum pumping system with base pressure about 10 -5 mBar. Details on the magnetron and the ion source in the sputtering chamber were given in [9]. The coatings thickness, adhesion properties, hardness and elastic modulus were evaluated by standard techniques [9].…”

A modification of superficial properties of materials by means of application of multiple coatings for their use in orthopaedics

“…(среднее число клеток, пролиферативная активность, морфология клеток) наблюдались в случае покрытий с наибольшими значениями параметров полярного компонента свободной поверхностной энергии SFE и фракционной полярности, таких как TiN, TiN/TiC 10 N 90 и оксидных покрытий. Большая поверхностная шероховатость, более высокая поверхностная энергия и фракционная полярность приводят к улучшенной адгезии фибробластов, возрастанию клеточной активности и скорости пролиферации клеток на поверхности биоматериала [15].…”