Surface morphology and drug loading characterization of 3D-printed methacrylate-based polymer facilitated by supercritical carbon dioxide

Ngo, Truc T.; Hoffman, L. Richard; Hoople, Gordon D.; Trevena, William; Shakya, Udeema; Barr, Gregory

doi:10.1016/j.supflu.2020.104786

Cited by 14 publications

(18 citation statements)

References 46 publications

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“…An important parameter in pharmaceutical 3DP is drug loading [95]. 3DP formulations with high drug loading are often sought after, as they will result in dosage forms that are concentrated enough to be administered as small units.…”

Section: Prediction Of Drug Product Propertiesmentioning

confidence: 99%

Disrupting 3D printing of medicines with machine learning

Elbadawi

McCoubrey

Gavins

et al. 2021

Trends in Pharmacological Sciences

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Section: Prediction Of Drug Product Propertiesmentioning

confidence: 99%

Disrupting 3D printing of medicines with machine learning

Elbadawi

McCoubrey

Gavins

et al. 2021

Trends in Pharmacological Sciences

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“…These methods are often very time-consuming and only porous structures [ 67 , 68 ] enable the possibility of suitable drug concentrations in the inner parts of the implant. Other, more exceptional, postprinting drug loading mechanisms are the incubation of implants with sublimated iodine [ 73 ], drug loading with supercritical carbon dioxide [ 74 ] or the manually filling of powdered drug or drug-loaded alginate gel into previously 3D-printed hollow or reservoir structures [ 75 , 76 , 77 , 78 ].…”

Section: Drug Loading Mechanismsmentioning

confidence: 99%

“…The shape of a 3D-printed object depends on the predefined computer-created design and is adjustable from simple to complex geometries. Proof-of-concept studies often use simple designs like discs, cylinders or cuboids [ 37 , 58 , 71 , 74 , 78 , 141 , 142 ] for the demonstration of the performance of 3D-printing for implants, such as antibacterial efficacy or controllable drug release, by varying implant properties [ 37 , 50 , 58 , 66 , 78 , 141 ].…”

Section: 3d-printing Of Drug-eluting Implantsmentioning

confidence: 99%

3D-Printing of Drug-Eluting Implants: An Overview of the Current Developments Described in the Literature

Domsta

Seidlitz

2021

Molecules

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The usage of 3D-printing for drug-eluting implants combines the advantages of a targeted local drug therapy over longer periods of time at the precise location of the disease with a manufacturing technique that easily allows modifications of the implant shape to comply with the individual needs of each patient. Research until now has been focused on several aspects of this topic such as 3D-printing with different materials or printing techniques to achieve implants with different shapes, mechanical properties or release profiles. This review is intended to provide an overview of the developments currently described in the literature. The topic is very multifaceted and several of the investigated aspects are not related to just one type of application. Consequently, this overview deals with the topic of 3D-printed drug-eluting implants in the application fields of stents and catheters, gynecological devices, devices for bone treatment and surgical screws, antitumoral devices and surgical meshes, as well as other devices with either simple or complex geometry. Overall, the current findings highlight the great potential of the manufacturing of drug-eluting implants via 3D-printing technology for advanced individualized medicine despite remaining challenges such as the regulatory approval of individualized implants.

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“…However, wet absorption is often unsuitable for loading bioactive molecules into scaffolds made of thermoplastic polymers due to slow solution diffusion into the bulk. By using scCO 2 , Ngo et al (2020) fabricated flurbiprofen-loaded acrylate-based 3D-printed systems and modulated the amount of loaded drug in the range of 12.72–24.08% by varying the operating temperature and pressure. Concomitantly, 3D-printed scaffolds processed with scCO 2 enabled the tuning of surface roughness features and macro/microporous porosities for specific application needs ( Zhou et al, 2016 ; Ngo et al, 2020 ).…”

Section: Spatial and Temporal Control Of Biomolecule Presentation In 3d Scaffolds Prepared By Additive Manufacturingmentioning

confidence: 99%

“…By using scCO 2 , Ngo et al (2020) fabricated flurbiprofen-loaded acrylate-based 3D-printed systems and modulated the amount of loaded drug in the range of 12.72–24.08% by varying the operating temperature and pressure. Concomitantly, 3D-printed scaffolds processed with scCO 2 enabled the tuning of surface roughness features and macro/microporous porosities for specific application needs ( Zhou et al, 2016 ; Ngo et al, 2020 ). Surface loading (strategy n°2) of bioactive molecules requires scaffold postprocessing treatments similar to the wet and vapor treatments described previously.…”

Section: Spatial and Temporal Control Of Biomolecule Presentation In 3d Scaffolds Prepared By Additive Manufacturingmentioning

confidence: 99%

Review on Computer-Aided Design and Manufacturing of Drug Delivery Scaffolds for Cell Guidance and Tissue Regeneration

Salerno¹,

Netti

2021

Front. Bioeng. Biotechnol.

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In the last decade, additive manufacturing (AM) processes have updated the fields of biomaterials science and drug delivery as they promise to realize bioengineered multifunctional devices and implantable tissue engineering (TE) scaffolds virtually designed by using computer-aided design (CAD) models. However, the current technological gap between virtual scaffold design and practical AM processes makes it still challenging to realize scaffolds capable of encoding all structural and cell regulatory functions of the native extracellular matrix (ECM) of health and diseased tissues. Indeed, engineering porous scaffolds capable of sequestering and presenting even a complex array of biochemical and biophysical signals in a time- and space-regulated manner, require advanced automated platforms suitable of processing simultaneously biomaterials, cells, and biomolecules at nanometric-size scale. The aim of this work was to review the recent scientific literature about AM fabrication of drug delivery scaffolds for TE. This review focused on bioactive molecule loading into three-dimensional (3D) porous scaffolds, and their release effects on cell fate and tissue growth. We reviewed CAD-based strategies, such as bioprinting, to achieve passive and stimuli-responsive drug delivery scaffolds for TE and cancer precision medicine. Finally, we describe the authors’ perspective regarding the next generation of CAD techniques and the advantages of AM, microfluidic, and soft lithography integration for enhancing 3D porous scaffold bioactivation toward functional bioengineered tissues and organs.

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Surface morphology and drug loading characterization of 3D-printed methacrylate-based polymer facilitated by supercritical carbon dioxide

Cited by 14 publications

References 46 publications

Disrupting 3D printing of medicines with machine learning

Disrupting 3D printing of medicines with machine learning

3D-Printing of Drug-Eluting Implants: An Overview of the Current Developments Described in the Literature

Review on Computer-Aided Design and Manufacturing of Drug Delivery Scaffolds for Cell Guidance and Tissue Regeneration

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