Surface molecularly imprinted polymer microspheres based on nano‐TiO₂ for selective recognition of kaempferol

Abstract

The molecular imprinting technique is a new method for preparing molecularly imprinted polymers (MIPs) with specific molecular recognition sites for certain target molecules. In this study, a novel, facile preparation method was presented, called "seed precipitation polymerization," for the synthesis of MIPs via surface imprinting and a support matrix. In the polymerization process, kaempferol was used as the template molecule, methacrylic acid as the functional monomer, nano-TiO 2 as the support, azodiisobutyronitrile as the initiator, and ethylene glycol dimethacrylate as the crosslinker in acetonitrile solvent. The synthesized T-MIP and MIP were analyzed by infrared spectroscopy and scanning electron microscopy. In addition, the obtained polymers were evaluated by adsorption isotherms and dynamic curves for their selective recognition properties for kaempferol. The results show that T-MIP shows regular spherical particles; the adsorption dynamic curves of T-MIP show that the adsorption capacity increases with time and reaches a maximum value and then finally reaches equilibrium, and the T-MIP exhibits a higher affinity for kaempferol than does the MIP. The adsorption follows pseudo-second-order kinetics, the Freundlich adsorption equation fits the experimental data well, and there is strong evidence for multiple-layer adsorption.

Synthesis and Applications of Molecularly Imprinted Polymers Modified TiO2 Nanomaterials: A Review

“…Huang et al [64] used nano-TiO 2 as the support matrix, 4-VP as the functional monomer, kaempferol as the template molecule, ethylene glycol dimethacrylate (EDMA) as the cross-linking agent to prepare kaempferol imprinted polymers and nano-TiO 2 -based MIPs were obtained at last after removing the template. The polymer particles made in this work appear as uniform microspheres with high selectivity and template recognition.…”

Kaempferol molecularly imprinted polymers: preparation, characterization and application to the separation of kaempferol from ginkgo leaves

“…In recent years, several studies have reported the preparation of KA‐MIPs 20–22 . Methacrylic acid, acrylamide and 4‐vinylpyridine were usually used as the functional monomer.…”

“…12,19 In recent years, several studies have reported the preparation of KA-MIPs. [20][21][22] Methacrylic acid, acrylamide and 4-vinylpyridine were usually used as the functional monomer. Ethylene glycol dimethacrylate (EDMA) was widely used as the crosslinker.…”

Recent Advances and Future Prospects of Molecular Imprinting Polymers as a Recognition Sensing System for Food Analysis: A Review

“…To overcome the downsides of mass polymerization, increasingly modern and complex polymerization strategies have been proposed to acquire MIPs with various structures, such as dots, solid structures, and coatings. At first, globules are commonly used for pressing segments for chromatography or solidphase extraction (SPE) [4] and are normally integrated by suspension polymerization [5], seed polymerization [6], emulsion polymerization [7], and precipitation polymerization [8]. Solid packing polymers are used for in situ segments that are prepared to be used directly after the evacuation of the format [9][10].…”