Surface molecularly imprinted polymer based on core-shell Fe3O4@MIL-101(Cr) for selective extraction of phenytoin sodium in plasma

Fabrication of a surface molecularly imprinted polymer membrane based on a single template and its application in the separation and extraction of phenytoin, phenobarbital and lamotrigine

“…Furthermore, the proposed method was compared with some other available methods based on MIPs or membrane extraction in the literature for PHT, PHB, and/or LTG. 28–33,47–53 As shown in Table 6, the extraction recovery of the current method for PHT in plasma was similar with that in the works by Jia's group 28 and Yaripour's group 33 but higher than that in other methods. 47,48,53 The extraction recovery of the current work for PHT in aqueous solution was obviously higher than that in the reference methods.…”

“…Recently, solid-phase extraction (SPE) based on molecularly imprinted polymers has aroused comprehensive attention from scientists in the elds of environmental and biomedical analysis, [24][25][26] which has been successfully applied in the determination of PHT, PHB or LTG in environmental water, urine, serum, and plasma. [27][28][29][30][31][32][33] Compared with the traditional SPE column, molecularly imprinted polymer membranes (MIPMs) have received more extensive attention for the separation and extraction of target compounds in biological samples or environmental water, given that they simultaneously possess the advantages of molecularly imprinting and membrane technology, such as specic recognition, specic surface area, and convenient operation. [34][35][36][37][38] However, to the best of our knowledge, MIPMs suitable for the targeted extraction and separation of PHT, PHB, and/or LTG in different matrices have not been reported to date.…”

Solid Phase-Based Microextraction Techniques in Therapeutic Drug Monitoring

“…HPLC-UV n.a. and 0.05 µg/mL 0.05-40 µg/mL [76] Cyclophosphamide, Ifosfamide, Cisplatin, Methotrexate, Pemetrexed disodium, Capecitabine, 5-fluorouracil, Gemcitabine, Doxorubicin, Fulvestrant, Tamoxifen, Irinotecan 100 µL of plasma MSPE: activation of the magnetic particles with 20 µL of hydrophilic-hydrophobic balance magnetic particles; 200 µL of methanol is transferred to a 96-well plate and stirred with a magnetic bar for 30 s; the activated magnetic particles are absorbed by the magnetic bar, transferred to another well plate and rinsed with 600 µL of water; 100 µL of the sample is added to another column of a 96-well plate and stirred with a magnetic bar for 30 s; elution of the drug-adsorbed magnetic particles that are absorbed by the magnetic bar are transferred to another well plate and rinsed with 600 µL of water for 30 s and then absorbed by the magnetic bar, transferred to a last column and rinsed with 800 µL of acetonitrile for 30 s to elute the analytes.…”

Imprinting Technology for Effective Sorbent Fabrication: Current State-of-Art and Future Prospects

“…The molecularly imprinted sorbents found an application in biomedical or clinical investigations of the levels of various important biomolecules, such as biogenic amines dopamine in human urine [151], tryptamine in human cerebrospinal fluid [152], psychoactive compounds such as cocaine [153] or cannabinoids [154], estrogens [155], various drugs such as gliclazide [156], nadifloxacin [157], phenytoin [158], zolpidem [159], and pramipexole [160] among others. Finally, molecularly imprinted sorbents were also used to monitor in vivo in animal model metabolites of the pharmacologically active compounds of plant origin such as hesperetin, a flavonoid, possessing antioxidant, anti-cancer, anti-inflammatory, cardiovascular protection and anti-rheumatic activities [161].…”