Surface-modified titanium and titanium-based alloys for improved osteogenesis: A critical review

Li, Jingling; Zheng, Yaxin; Yu, Zihe; Kankala, Ranjith Kumar; Lin, Qianying; Shi, Jingbo; Chen, Chao; Luo, Kai; Chen, Aizheng; Zhong, Quan

doi:10.1016/j.heliyon.2023.e23779

Cited by 4 publications

(1 citation statement)

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“…The increasing application of titanium in dental implant is due to multiple beneficial effects [ 35 , 36 ]. To overcome titanium bio-inertness in dental implant procedures, subtractive or additive surface modification methods are commonly implemented to create nano- or micro-scale structures and promote osseointegration [ 37 ]. However, these surface modification methods have the potential risk of introducing foreign matter to the implant surface during the manufacturing process, thus generating surface contamination, which reduces safety and efficacy.…”

Section: Discussionmentioning

confidence: 99%

Titanium Surfaces with a Laser-Produced Microchannel Structure Enhance Pre-Osteoblast Proliferation, Maturation, and Extracellular Mineralization In Vitro

Chen,

Chiang,

Chen

et al. 2024

IJMS

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The clinical success of dental titanium implants is profoundly linked to implant stability and osseointegration, which comprises pre-osteoblast proliferation, osteogenic differentiation, and extracellular mineralization. Because of the bio-inert nature of titanium, surface processing using subtractive or additive methods enhances osseointegration ability but limits the benefit due to accompanying surface contamination. By contrast, laser processing methods increase the roughness of the implant surface without contamination. However, the effects of laser-mediated distinct surface structures on the osteointegration level of osteoblasts are controversial. The role of a titanium surface with a laser-mediated microchannel structure in pre-osteoblast maturation remains unclear. This study aimed to elucidate the effect of laser-produced microchannels on pre-osteoblast maturation. Pre-osteoblast human embryonic palatal mesenchymal cells were seeded on a titanium plate treated with grinding (G), sandblasting with large grit and acid etching (SLA), or laser irradiation (L) for 3–18 days. The proliferation and morphology of pre-osteoblasts were evaluated using a Trypan Blue dye exclusion test and fluorescence microscopy. The mRNA expression, protein expression, and protein secretion of osteogenic differentiation markers in pre-osteoblasts were evaluated using reverse transcriptase quantitative polymerase chain reaction, a Western blot assay, and a multiplex assay, respectively. The extracellular calcium precipitation of pre-osteoblast was measured using Alizarin red S staining. Compared to G- and SLA-treated titanium surfaces, the laser-produced microchannel surfaces enhanced pre-osteoblast proliferation, the expression/secretion of osteogenic differentiation markers, and extracellular calcium precipitation. Laser-treated titanium implants may enhance the pre-osteoblast maturation process and provide extra benefits in clinical application.

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Section: Discussionmentioning

confidence: 99%