Surface-Modified Graphene Oxide with Compatible Interface Enhances Poly-L-Lactic Acid Bone Scaffold

As two promising biomaterials for bone implants, biomedical metals have favorable mechanical properties and good machinability but lack of bioactivity; while bioceramics are known for good biocompatibility or even bioactivity but limited by their high brittleness. Biocermets, a kind of composites composing of bioceramics and biomedical metals, have been developed as an effective solution by combining their complementary advantages. This paper focused on the recently studied biocermets for bone implant applications. Concretely, biocermets were divided into ceramic-based biocermets and metal-based biocermets according to the phase percentages. Their characteristics were systematically summarized, and the fabrication methods for biocermets were reviewed and compared. Emphases were put on the interactions between bioceramics and biomedical metals, as well as the performance improvement mechanisms. More importantly, the main methods for the interfacial reinforcing were summarized, and the corresponding interfacial reinforcing mechanisms were discussed. In addition, the in vitro and in vivo biological performances of biocermets were also reviewed. Finally, future research directions were proposed on the advancement in component design, interfacial reinforcing and forming mechanisms for the fabrication of high-performance biocermets.

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“…These surface properties include surface energy, surface charge, wettability, surface chemistry and surface topography, etc. [159,160].…”

Section: Surface Modificationmentioning

confidence: 99%

Advances in biocermets for bone implant applications

et al. 2020

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“…As an emerging additive manufacturing technique, selective laser sintering (SLS) can precisely construct bone scaffold with complicated structure and customized shape from 3D digital data by sequentially fusing region in a powder bed, layer-by-layer, via a computer-controlled scanning laser beam. More particularly, any powdered biomaterial that will fuse but not decompose under the irradiation of laser beam can be used to fabricate scaffold [18].…”

Section: Introductionmentioning

confidence: 99%

Enhanced Crystallinity and Antibacterial of PHBV Scaffolds Incorporated with Zinc Oxide

Shuai

Wang

et al. 2020

Journal of Nanomaterials

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Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) has a great potential in bone repair, but unfortunately, the poor mechanical properties limit its further application. In this work, zinc oxide (ZnO) nanoparticles were incorporated into PHBV porous scaffold fabricated by selective laser sintering technique. It was because ZnO nanoparticles could provide nucleating sites for the orderly stacking of polymer chains, thereby enhancing the crystallinity of PHBV. It was well known that the mechanical properties of PHBV scaffold could be enhanced with the increase of crystallinity. More significantly, the released Zn2+ would combine negatively charged cell membranes of bacterial through electrostatic interaction and consequently destructed the protein structure and resulted in the death of bacterial, which was highly desired in reducing the risk of implant infection. Results indicated that the relative crystallinity of scaffold with 3 wt.% ZnO increased remarkably from 38% to 64% compared to pure PHBV scaffold, which effectively enhanced the compression strength and modulus by 56% and 51.5%, respectively. Moreover, the scaffold had a favorable antibacterial activity. Cell culture experiments proved that the scaffold could promote the cell behaviors. The positive results demonstrated the scaffold may serve as a potential replacement in bone repair.

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“…To synthesize the AZ61–TiO 2 /GO biocomposite, 100 g of AZ61 and 20 g of TiO 2 /GO powders were separately dispersed in absolute ethanol for 1 h. Then, mixing the solutions and stirring it at 800 rpm for 3 h. The resulting AZ61–TiO 2 /GO solution was then vacuum-filtered and dried at 55 °C for 4 h. Finally, the mixed powders were obtained and used for the preparation of AZ61–TiO 2 /GO biocomposites. The samples were fabricated on a SLM system systematically. , First, the processing platform was adjusted to a suitable height, and one layer of AZ61–TiO 2 /GO powder was laid on the platform, followed by the input of argon gas to transfer the oxygen and water in the platform. Then, a laser beam selectively melted the powder, according to the predesigned scanning path with a laser power of 72 W and a scanning speed of 22 mm·s –1 .…”

Section: Methodsmentioning

confidence: 99%

TiO₂-Induced In Situ Reaction in Graphene Oxide-Reinforced AZ61 Biocomposites to Enhance the Interfacial Bonding

Shuai

Wang

Bin

et al. 2020

ACS Appl. Mater. Interfaces

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Graphene oxide (GO) can improve the degradation resistance of biomedical Mg alloy because of its excellent impermeability and outstanding chemical inertness. However, the weak interfacial bonding between GO and Mg matrix leads to easily detaching during degradation. In this study, in situ reaction induced by TiO 2 took place in the AZ61−GO biocomposite to enhance the interfacial bonding between GO and Mg matrix. For the specific process, TiO 2 was uniformly and tightly deposited onto the GO surface by hydrothermal reaction (TiO 2 /GO) first and then used for fabricating AZ61−TiO 2 /GO biocomposites by selective laser melting (SLM). Results showed that TiO 2 was in situ reduced by magnesiothermic reaction during SLM process, and the reduzate Ti, on the one hand, reacted with Al in the AZ61 matrix to form TiAl 2 and, on the other hand, reacted with GO to form TiC at the AZ61−GO interface. Owing to the enhanced interfacial bonding, the AZ61−TiO 2 /GO biocomposite showed 12.5% decrease in degradation rate and 10.1% increase in compressive strength as compared with the AZ61−GO biocomposite. Moreover, the AZ61− TiO 2 /GO biocomposite also showed good cytocompatibility because of the slowed degradation. These findings may provide guidance for the interfacial enhancement in GO/metal composites for biomedical applications.

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Surface-Modified Graphene Oxide with Compatible Interface Enhances Poly-L-Lactic Acid Bone Scaffold

Cited by 28 publications

References 55 publications

Advances in biocermets for bone implant applications

Advances in biocermets for bone implant applications

Enhanced Crystallinity and Antibacterial of PHBV Scaffolds Incorporated with Zinc Oxide

TiO₂-Induced In Situ Reaction in Graphene Oxide-Reinforced AZ61 Biocomposites to Enhance the Interfacial Bonding

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Surface-Modified Graphene Oxide with Compatible Interface Enhances Poly-L-Lactic Acid Bone Scaffold

Cited by 28 publications

References 55 publications

Advances in biocermets for bone implant applications

Advances in biocermets for bone implant applications

Enhanced Crystallinity and Antibacterial of PHBV Scaffolds Incorporated with Zinc Oxide

TiO2-Induced In Situ Reaction in Graphene Oxide-Reinforced AZ61 Biocomposites to Enhance the Interfacial Bonding

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Product

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TiO₂-Induced In Situ Reaction in Graphene Oxide-Reinforced AZ61 Biocomposites to Enhance the Interfacial Bonding