Surface modifications of the titanium mesh for cranioplasty using selenium nanoparticles coating

Cavalu, Simona; Antoniac, Iulian Vasile; Fritea, Luminița; Mates, Ileana Mariana; Milea, Claudia; Laslo, Vasile; Vicaş, Simona Ioana; Mohan, Aurel George

doi:10.1080/01694243.2018.1490067

Cited by 32 publications

(17 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This result is in agreement with some previous papers [ 35 , 36 ]. The SeNPs’ production using different lactic acid bacteria show unique structured nanospheres with regular and uniform size, comparative with chemical synthesis [ 27 , 37 , 38 ]. To date, different microorganisms ( Lactobacillus sp.…”

Section: Resultsmentioning

confidence: 99%

Nano Selenium—Enriched Probiotics as Functional Food Products against Cadmium Liver Toxicity

et al. 2021

Self Cite

View full text Add to dashboard Cite

Since cadmium is a toxic metal that can cause serious health problems for humans, it is necessary to find bioremediation solutions to reduce its harmful effects. The main goal of our work was to develop a functional food based on elemental selenium nanoparticles (SeNPs) obtained by green synthesis using Lactobacillus casei and to validate their ability to annihilate the hepatic toxic effects induced by cadmium. The characterization of SeNPs was assessed by UV–Vis spectroscopy, FTIR, XRD, DLS and TEM. In order to investigate the dose-dependent protective effects of SeNPs on Cd liver toxicity, mice were assigned to eight experimental groups and fed by gavage, with 5 mg/kg b.w. cadmium, respectively, with co-administration with SeNPs or lacto-SeNPs (LSeNPs) in 3 doses (0.1, 0.2 and 0.4 mg/kg b.w.) for 30 days. The protective effect was demonstrated by the restoration of blood hepatic markers (AST, ALT, GGT and total bilirubin) and antioxidant enzymes, such as catalase (CAT) and glutathione peroxidase (GPx). Moreover, the antioxidant capacity of mice plasma by the FRAP assay, revealed the highest antioxidant capacity for the 0.2 mg/kg LSeNPs group. Histopathological analysis demonstrated the morphological alteration in the group that received only cadmium and was restored after the administration of SeNPs or LSeNPs, while the immunohistochemical analysis of the bcl family revealed anti-apoptotic effects; the Q-PCR analysis showed an upregulation of hepatic inflammatory markers for the group exposed to Cd and a decreased value for the groups receiving oral SeNPs/ LSeNPs in a dose-dependent manner. The best protective effects were obtained for LSeNPs. A functional food that includes both probiotic bacteria and elemental SeNPs could be successfully used to annihilate Cd-induced liver toxicity, and to improve both nutritional values and health benefits.

show abstract

Section: Resultsmentioning

confidence: 99%

Nano Selenium—Enriched Probiotics as Functional Food Products against Cadmium Liver Toxicity

et al. 2021

Self Cite

View full text Add to dashboard Cite

show abstract

“…Graphene-based nanomaterials are another innovative solution for tissue engineering in the dental field [233][234][235]. Selenium nanoparticles were involved in surface modification of the titanium mesh for cranioplasty [236][237][238]. In the nanoparticle field, magnetic nanoparticles represent a special class, because they demonstrate an intrinsic association with oncological domain.…”

Section: Challenges and Discussion Regarding The Mnps Use In Cancer Therapymentioning

confidence: 99%

Magnetic Nanoparticles Used in Oncology

et al. 2021

Self Cite

View full text Add to dashboard Cite

Recently, magnetic nanoparticles (MNPs) have more and more often been used in experimental studies on cancer treatments, which have become one of the biggest challenges in medical research. The main goal of this research is to treat and to cure advanced or metastatic cancer with minimal side effects through nanotechnology. Drug delivery approaches take into account the fact that MNPs can be bonded to chemotherapeutical drugs, nucleic acids, synthetized antibodies or radionuclide substances. MNPs can be guided, and different treatment therapies can be applied, under the influence of an external magnetic field. This paper reviews the main MNPs’ synthesis methods, functionalization with different materials and highlight the applications in cancer therapy. In this review, we describe cancer cell monitorization based on different types of magnetic nanoparticles, chemotherapy, immunotherapy, magnetic hyperthermia, gene therapy and ferroptosis. Examples of applied treatments on murine models or humans are analyzed, and glioblastoma cancer therapy is detailed in the review. MNPs have an important contribution to diagnostics, investigation, and therapy in the so called theranostics domain. The main conclusion of this paper is that MNPs are very useful in different cancer therapies, with limited side effects, and they can increase the life expectancy of patients with cancer drug resistance.

show abstract

“…In addition to the proposal to use native or derived polysaccharides as biologically active substances, several studies report the use of these in nanoformulations for biomedical applications. These alternative materials are currently used in several innovations in the nanotechnological area [47,48]. Mainly, plant-derived galactomannans have been frequently used to develop several types of drug delivery systems, including polymeric nanoparticles [49][50][51], liposomes [52], microparticles [14,53], beads [54], hydrogels [55], aerogels [1,13], and mucoadhesive systems [2].…”

Section: Future Perspectives and Conclusionmentioning

confidence: 99%

Are Structurally Modified Galactomannan Derivatives Biologically Active?

et al. 2021

View full text Add to dashboard Cite

Galactomannans are versatile macromolecules with broad industrial potential. The influence of changes in the chemical structures and respective bioactivities of these polysaccharides have been extensively studied. The derivatives obtained by sulfation, complexation, and phosphorylation are the most studied biological properties in galactomannans. The derivatives obtained have shown several pharmacological activities such as antiviral, antimicrobial, anticoagulant, fibrinolytic, chemopreventive, anticancer, antioxidant, chondroprotective, analgesic, immunomodulatory, and antileishmanial. Considering the relevance of these studies, we aim to provide an overview of studies that apply galactomannan modification or derivatization strategies to improve their properties for applications in the biomedical area. We identified the success of most modified galactomannans for pharmacological purposes. However, some studies found loss of bioactivity of the original polysaccharide after chemical changes to its original structures.

show abstract

Surface modifications of the titanium mesh for cranioplasty using selenium nanoparticles coating

Cited by 32 publications

References 34 publications

Nano Selenium—Enriched Probiotics as Functional Food Products against Cadmium Liver Toxicity

Nano Selenium—Enriched Probiotics as Functional Food Products against Cadmium Liver Toxicity

Magnetic Nanoparticles Used in Oncology

Are Structurally Modified Galactomannan Derivatives Biologically Active?

Contact Info

Product

Resources

About