Surface modifications of scaffolds for bone regeneration

Teimouri, Reihaneh; Abnous, Khalil; Taghdisi, Seyed Mohammad; Ramezani, Mohammad; Alibolandi, Mona

doi:10.1016/j.jmrt.2023.05.076

Cited by 21 publications

(9 citation statements)

References 128 publications

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“…Direct surface treatment of polymeric scaffolds has also been utilized to invoke bioactivity. 76,91 Plasma treatment, wherein an electric current passes through a gas ( e.g. , oxygen, argon, and ammonia), is a popular method.…”

Section: Imparting Bioactivity To Scaffoldsmentioning

confidence: 99%

“… 166 Biomolecules, such as the fibronectin-derived peptide sequence Arg–Gly–Asp–Ser (RGDS), are often incorporated into the scaffold to direct or support desired stem cell adhesion, spreading, and differentiation. 91 Exogenous (external) growth factors, particularly BMP-2, have also been incorporated into scaffolds to accelerate osteogenesis, although these strategies often risk off-target effects in vivo . 32 A wide range of methods have been used for biomolecule incorporation, as a single method of biomolecule incorporation is not necessarily universally effective for all scaffold types.…”

Section: Assessment Of Scaffold Of Bioactivitymentioning

confidence: 99%

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Trends in bioactivity: inducing and detecting mineralization of regenerative polymeric scaffolds

Nitschke,

Beltran,

Hahn

et al. 2024

J. Mater. Chem. B

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Section: Imparting Bioactivity To Scaffoldsmentioning

confidence: 99%

Section: Assessment Of Scaffold Of Bioactivitymentioning

confidence: 99%

Trends in bioactivity: inducing and detecting mineralization of regenerative polymeric scaffolds

Nitschke,

Beltran,

Hahn

et al. 2024

J. Mater. Chem. B

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“…The surface of PPC can also be biologically modified after certain treatments. Surface treatments like plasma, ionizing radiation, laser irradiation or silane coupling can impart hydrophilic surfaces and improve the cell adhesion and biocompatibility for PPC [ 111 , 112 , 113 ]. For example, the surface of PPC/laponite nanocomposites can form interconnected microporous structures after the treatment with sodium hydroxide, which can boost the surface roughness, surface energy and protein adsorption capacity of PPC [ 114 ].…”

Section: Modifications Of Ppcmentioning

confidence: 99%

Poly(Propylene Carbonate)-Based Biodegradable and Environment-Friendly Materials for Biomedical Applications

Wang,

Li,

Yang

et al. 2024

IJMS

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Poly(propylene carbonate) (PPC) is an emerging “carbon fixation” polymer that holds the potential to become a “biomaterial of choice” in healthcare owing to its good biocompatibility, tunable biodegradability and safe degradation products. However, the commercialization and wide application of PPC as a biomedical material are still hindered by its narrow processing temperature range, poor mechanical properties and hydrophobic nature. Over recent decades, several physical, chemical and biological modifications of PPC have been achieved by introducing biocompatible polymers, inorganic ions or small molecules, which can endow PPC with better cytocompatibility and desirable biodegradability, and thus enable various applications. Indeed, a variety of PPC-based degradable materials have been used in medical applications including medical masks, surgical gowns, drug carriers, wound dressings, implants and scaffolds. In this review, the molecular structure, catalysts for synthesis, properties and modifications of PPC are discussed. Recent biomedical applications of PPC-based biomaterials are highlighted and summarized.

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“…Many kinds of bone scaffolds for bone tissue regeneration are developed; collagen [12] and ceramic type scaffolds, including tricalcium phosphate (TCP) [13] and hydroxyapatite (HA) [14], and polymer-type scaffolds, including poly lacticco-glycolic acid (PLGA) [15] and polycaprolactone (PCL) [16] have already been used in the clinical application. Chemical surface functionalization of the scaffold is one of the approaches to improve its performance for biological molecules, such as drugs, growth factors, and peptides [17]. Researchers in the field of interface science have developed the modifications of scaffolds surface for peptide-induced bone tissue regeneration [17][18][19].…”

Section: Introductionmentioning

confidence: 99%

“…Chemical surface functionalization of the scaffold is one of the approaches to improve its performance for biological molecules, such as drugs, growth factors, and peptides [17]. Researchers in the field of interface science have developed the modifications of scaffolds surface for peptide-induced bone tissue regeneration [17][18][19]. In a previous study, polydopamine (pDA)-coated PCL nanofiber scaffold was shown to enhance osteoconductivity, followed by covalent immobilization of bone morphogenetic protein (BMP)-7-derived peptides onto the pDA-coated nanofiber scaffold surface [18].…”

Section: Introductionmentioning

confidence: 99%

Comparison of Osteoconductive Ability of Two Types of Cholesterol-Bearing Pullulan (CHP) Nanogel-Hydrogels Impregnated with BMP-2 and RANKL-Binding Peptide: Bone Histomorphometric Study in a Murine Calvarial Defect Model

Xie

Rashed

Sasaki

et al. 2023

IJMS

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The receptor activator of NF-κB ligand (RANKL)-binding peptide is known to accelerate bone morphogenetic protein (BMP)-2-induced bone formation. Cholesterol-bearing pullulan (CHP)-OA nanogel-crosslinked PEG gel (CHP-OA nanogel-hydrogel) was shown to release the RANKL-binding peptide sustainably; however, an appropriate scaffold for peptide-accelerated bone formation is not determined yet. This study compares the osteoconductivity of CHP-OA hydrogel and another CHP nanogel, CHP-A nanogel-crosslinked PEG gel (CHP-A nanogel–hydrogel), in the bone formation induced by BMP-2 and the peptide. A calvarial defect model was performed in 5-week-old male mice, and scaffolds were placed in the defect. In vivo μCT was performed every week. Radiological and histological analyses after 4 weeks of scaffold placement revealed that the calcified bone area and the bone formation activity at the defect site in the CHP-OA hydrogel were significantly lower than those in the CHP-A hydrogel when the scaffolds were impregnated with both BMP-2 and the RANKL-binding peptide. The amount of induced bone was similar in both CHP-A and CHP-OA hydrogels when impregnated with BMP-2 alone. In conclusion, CHP-A hydrogel could be an appropriate scaffold compared to the CHP-OA hydrogel when the local bone formation was induced by the combination of RANKL-binding peptide and BMP-2, but not by BMP-2 alone.

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Surface modifications of scaffolds for bone regeneration

Cited by 21 publications

References 128 publications

Trends in bioactivity: inducing and detecting mineralization of regenerative polymeric scaffolds

Trends in bioactivity: inducing and detecting mineralization of regenerative polymeric scaffolds

Poly(Propylene Carbonate)-Based Biodegradable and Environment-Friendly Materials for Biomedical Applications

Comparison of Osteoconductive Ability of Two Types of Cholesterol-Bearing Pullulan (CHP) Nanogel-Hydrogels Impregnated with BMP-2 and RANKL-Binding Peptide: Bone Histomorphometric Study in a Murine Calvarial Defect Model

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