Surface Modification with Poly(sulfobetaine methacrylate-co-acrylic acid) To Reduce Fibrinogen Adsorption, Platelet Adhesion, and Plasma Coagulation

Abstract

Zwitterionic sulfobetaine methacrylate (SBMA) polymers were known to possess excellent antifouling properties due to high hydration capacity and neutral charge surface. In this study, copolymers of SBMA and acrylic acid (AA) with a variety of compositions were synthesized and were immobilized onto polymeric substrates with layer-by-layer polyelectrolyte films via electrostatic interaction. The amounts of platelet adhesion and fibrinogen adsorption were determined to evaluate hemocompatibility of poly(SBMA-co-AA)-modified substrates. Among various deposition conditions by modulating SBMA ratio in the copolymers and pH of the deposition solution, poly(SBMA(56)-co-AA(44)) deposited at pH 3.0 possessed the best hemocompatibility. This work demonstrated that poly(SBMA-co-AA) copolymers adsorbed on polyelectrolyte-base films via electrostatic interaction improve hemocompatibility effectively and are applicable for various substrates including TCPS, PU, and PDMS. Furthermore, poly(SBMA-co-AA)-coated substrate possesses great durability under rigorous conditions. The preliminary hemocompatibility tests regarding platelet adhesion, fibrinogen adsorption, and plasma coagulation suggest the potential of this technique for the application to blood-contacting biomedical devices.

Highly crosslinked layer-by-layer polyelectrolyte FO membranes: Understanding effects of salt concentration and deposition time on FO performance

“…LbL is a flexible process that offers a variety of functionalized materials for a range of applications such as biosensors [13], drug delivery [14], membrane separations (e.g. pervaporation [15][16][17][18], fuel cells [19], microfiltration [20], nanofiltration [21,22], reverse osmosis [23] and forward osmosis [8][9][10][11][12]), biomedical devices [24], food packaging [25] and others [26]. In LbL polyelectrolyte fabrication process, polyelectrolyte multilayers are normally assembled by the sequential adsorption of polyanions and polycations manually or automatically via dip-coating [21,27,28], spraying [29,30] or spin-coating [31] methods through electrostatic interaction.…”

Thermo-Responsive Hydrogels for Stimuli-Responsive Membranes

“…Along with the other IUPAC names for the compound (CAS# monomer: 3637-26-1, polymer: 41488-70-4), this monomer has been called sulfobetaine methacrylate (SBMA), DMMAPS and MEDSAH by other workers [27,28,[50][51][52]. It was noted by Soto and Galin that although polysulfobetaine solubility is good in protic solvents, solubility in water above 20 o C was unusual and was reaffirmed later [48].…”

“…However, it is shown that different crosslink distances due to linker selection will have an impact of mechanical properties such as Young's modulus. Polysulfobetaines have also gained much interest as a biocompatible material with high protein fouling resistance [50]. Copolymerizations with other biocompatible thermo-responsive polymers have formed temperature triggered cell-detachment surfaces [57].…”

Stimuli-Responsive and Hemocompatible Pseudozwitterionic Interfaces

“…14 Zwitterionic polymers used in the design of antifouling surfaces or membranes are usually derivatives of sulfobetaine, carboxybetaine or phosphobetaine. [15][16][17][18][19][20] These three pendant groups have proven their efficiency to repel proteins, bacteria or cells. However, as reminded in a recent study, zwitterionic-based hydrogels and films may partially lose their antifouling property when the surface chemistry is modified in order to add a supplementary bioactive function through the implementation of additional conjugate.…”