Surface Modification Techniques to Produce Micro/Nano-scale Topographies on Ti-Based Implant Surfaces for Improved Osseointegration

Hou, Chuang; J, An; Zhao, Duoyi; Ma, Xiao; Zhang, Weilin; Zhao, Wei; Wu, Meng; Zhang, Zhe; Yuan, Fusheng

doi:10.3389/fbioe.2022.835008

Cited by 31 publications

(20 citation statements)

References 109 publications

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“…The 3D printing, bioactive nanoparticles and stimulus-dependent variable materials have been research hotspots in recent years, and their combination with surface modification is expected to produce more new orthopedic implants. In addition, it is a trend of surface modification to produce composite surfaces structures with multiple morphologies and sizes [26].…”

Section: Discussionmentioning

confidence: 99%

Nano-scale surface modification of dental implants – An emerging boon for osseointegration and biofilm control

Sachin

Uppoor

Nayak

2022

Acta Marisiensis - Seria Medica

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Implant therapy is a commonly based method of replacing missing teeth. A range of physical, chemical, and biological modifications have been applied to the surface of titanium implants to improve their biological performance and osseointegration outcomes. Implant surface characteristics play an important function in several peri-implant cellular and molecular mechanisms. Clinicians are commonly placing dental implants with various surface roughness and modifications including plasma-sprayed, acid-etched, blasted, oxidized, hydroxyapatite-coated, or combinations of these procedures. Surface modifications are to facilitate early osseointegration and to ensure a long-term bone-to-implant contact without substantial marginal bone loss can be accomplished. It is apparent that different modifications have a range of beneficial effects, it is essential to consider at what time point and in what conditions these effects occur. This article reviews existing surface modification technologies of mainstream dental implants and the correlation between implant surface coatings and their performance of osseointegration or anti-bacterial ability it needs to be evaluated.

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Section: Discussionmentioning

confidence: 99%

Nano-scale surface modification of dental implants – An emerging boon for osseointegration and biofilm control

Sachin

Uppoor

Nayak

2022

Acta Marisiensis - Seria Medica

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“…2 The protective oxide has been shown to promote osseous and soft tissue adhesion by facilitating the deposition of bone-like apatite layer in simulated bodily fluid (SBF). 2 Berger et al 3 and Hou et al 4 proved that introducing porosity to Ti-Ta alloys can induce the trapping of specific proteins on the implant surface while also promoting mechanical interlocking between the bone and implant material. On the other hand, Oshida et al 5 stressed the importance of considering the tribological performance when using porous Ti-Ta alloy implants for hip and knee replacements.…”

Section: Introductionmentioning

confidence: 99%

The effect of CNTs/PEEK coating thickness on the friction and wear behavior of porous Ti‐30Ta alloys for biomaterial implants

Halim

Yajid

Hassan

et al. 2023

J of Applied Polymer Sci

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Electrophoretic deposition was used to deposit carbon nanotube/polyether ether ketone (CNTs/PEEK) composite coatings onto porous titanium‐tantalum (Ti‐30Ta) substrates at different PEEK concentrations (4.5, 6.0, and 7.5 mg/mL). Coatings were analyzed for thickness, porosity, surface roughness, microhardness and bonding strength, with higher PEEK concentrations producing thicker and more uniform coatings. However, optimal coating thickness showed highest bonding strength; lower and higher thickness led to decreased bonding strength. The tribological properties of the CNTs/PEEK coated Ti‐30Ta samples of different thicknesses (50, 70, and 100 μm) were evaluated using ball‐on‐flat linear reciprocating sliding tests under dry and wet conditions using simulated body fluid (SBF) as a lubricant. The CNTs/PEEK coatings provided excellent tribological protection under dry friction, with thicker coatings having lower friction and negligible wear. However, under wet sliding, the coating's wear rate increased significantly due to softening of the rubbing surface caused by SBF lubrication that increase transfer film onto the counter body surface. Coating with optimal thickness of 74 μm demonstrated the lowest friction and wear under SBF lubrication due to its highest hardness and bonding strength. This study highlights the importance of controlling coating thickness in determining the performance of the CNTs/PEEK coatings for orthopedic implants.

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“…They demonstrated that the functional TNTs remarkably improved the expression of early osteogenic differentiation markers. Among these biomimetic modifications, titanium surfaces with nanotopography and hydrophilic properties are considered to be a simple and promising tool for enhancing osseointegration [ 7 , 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

In Vitro and In Vivo Studies of Hydrogenated Titanium Dioxide Nanotubes with Superhydrophilic Surfaces during Early Osseointegration

Wang

Gao

et al. 2022

Cells

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Titanium-based implants are often utilized in oral implantology and craniofacial reconstructions. However, the biological inertness of machined titanium commonly results in unsatisfactory osseointegration. To improve the osseointegration properties, we modified the titanium implants with nanotubular/superhydrophilic surfaces through anodic oxidation and thermal hydrogenation and evaluated the effects of the machined surfaces (M), nanotubular surfaces (Nano), and hydrogenated nanotubes (H-Nano) on osteogenesis and osseointegration in vitro and in vivo. After incubation of mouse bone marrow mesenchymal stem cells on the samples, we observed improved cell adhesion, alkaline phosphatase activity, osteogenesis-related gene expression, and extracellular matrix mineralization in the H-Nano group compared to the other groups. Subsequent in vivo studies indicated that H-Nano implants promoted rapid new bone regeneration and osseointegration at 4 weeks, which may be attributed to the active osteoblasts adhering to the nanotubular/superhydrophilic surfaces. Additionally, the Nano group displayed enhanced osteogenesis in vitro and in vivo at later stages, especially at 8 weeks. Therefore, we report that hydrogenated superhydrophilic nanotubes can significantly accelerate osteogenesis and osseointegration at an early stage, revealing the considerable potential of this implant modification for clinical applications.

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Surface Modification Techniques to Produce Micro/Nano-scale Topographies on Ti-Based Implant Surfaces for Improved Osseointegration

Cited by 31 publications

References 109 publications

Nano-scale surface modification of dental implants – An emerging boon for osseointegration and biofilm control

Nano-scale surface modification of dental implants – An emerging boon for osseointegration and biofilm control

The effect of CNTs/PEEK coating thickness on the friction and wear behavior of porous Ti‐30Ta alloys for biomaterial implants

In Vitro and In Vivo Studies of Hydrogenated Titanium Dioxide Nanotubes with Superhydrophilic Surfaces during Early Osseointegration

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