Surface modification strategies and the functional mechanisms of gold nanozyme in biosensing and bioassay

Garehbaghi, Sanam; Ashrafi, Amir M.; Adam, Vojtěch; Richtera, Lukáš

doi:10.1016/j.mtbio.2023.100656

Cited by 4 publications

(1 citation statement)

References 132 publications

(181 reference statements)

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“…For the nanoparticles, most catalytic reactions occur on the surface where the activation energy of the substrates can be lowered through electron transfer or conformational change. 124,125 Thus, surface modification can influence biocompatibility, solubility, and most importantly, their catalytic activities. 126,127 It has been reported that Fe 3 O 4 nanozymes modified with histidine on the surface exhibited a 10-fold increase in binding affinity for H 2 O 2 and a 20-fold higher peroxidase activity compared to the naked ones.…”

Section: Discussionmentioning

confidence: 99%

Advances in colorimetric biosensors of exosomes: novel approaches based on natural enzymes and nanozymes

Sun,

Zhang,

et al. 2024

Nanoscale

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Section: Discussionmentioning

confidence: 99%

Advances in colorimetric biosensors of exosomes: novel approaches based on natural enzymes and nanozymes

Sun,

Zhang,

et al. 2024

Nanoscale

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Marine‐Derived Nanozyme‐Crosslinked Self‐Adaptive Hydrogels for Programmed Regulating the Regeneration Process

Wang,

Wen,

et al. 2024

Adv Funct Materials

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Self‐adaptive hydrogels that can specifically respond to pathological cues and match the highly ordered tissue regeneration process are significantly on‐demand for effective wound management. Herein, multifunctional marine‐derived gold clusterzyme (AuNCs)‐based self‐adaptive hydrogels with microenvironment triggered release behavior are elaborately fabricated for on‐demand antioxidant, anti‐inflammatory and immunoregulation. The marine mussel‐derived catechol ligands (L‐3,4‐dihydroxyphenylalanine) endow AuNCs with enhanced superoxide dismutase‐mimic activity due to their high affinity to superoxide anion free radical (O2−•) and unique electron transfer mechanism, leading to 100% inhibition of O2−•. Upon uniformly crosslinking with phenylboronic acid‐modified marine‐derived sodium alginate (PBA‐Sa), the obtained AuNCs@PBA‐Sa hydrogels exhibit outstanding self‐healing property, tunable degradation and good removability. Meanwhile, AuNCs can greatly enhance the mechanical property and confer the hydrogel with favorable tissue adhesion for rapid hemostasis. Furthermore, injectable AuNCs@PBA‐Sa hydrogels can not only adapt their shape to the irregular wound, but also smartly adapt their microstructure to the physiological microenvironment of diabetic wound, leading to the responsive release of AuNCs upon the break of boronate ester bonds. The released gold clusterzymes can actively induce the generation of M2‐macrophage, demonstrating an outstanding anti‐inflammatory and pro‐regeneration effect. Therefore, the present multifunctional clusterzyme‐based self‐adaptive hydrogels hold great potential for remolding the dynamic tissue regeneration microenvironment and smart wound management.

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Nanozyme catalysis in a crowded environment: the impact of diffusion and surface shielding

Panferov,

Liu

2024

Nano Res.

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Surface modification strategies and the functional mechanisms of gold nanozyme in biosensing and bioassay

Cited by 4 publications

References 132 publications

Advances in colorimetric biosensors of exosomes: novel approaches based on natural enzymes and nanozymes

Advances in colorimetric biosensors of exosomes: novel approaches based on natural enzymes and nanozymes

Marine‐Derived Nanozyme‐Crosslinked Self‐Adaptive Hydrogels for Programmed Regulating the Regeneration Process

Nanozyme catalysis in a crowded environment: the impact of diffusion and surface shielding

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