Surface modification of titanium implants with Mg-containing coatings to promote osseointegration

Wang, Siyi; Zhao, Xiao; Hsu, Yi-Chu; He, Yaohua; Wang, Feilong; Yang, Fan; Yan, Fanyu; Xia, Dandan; Liu, Yunsong

doi:10.1016/j.actbio.2023.07.048

Cited by 23 publications

(13 citation statements)

References 77 publications

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“…Favorable vascularization is beneficial for osteogenesis and provides an adequate supply for local metabolism . Therefore, accelerated bone healing needs to be considered in both osteogenesis and angiogenesis. , Mg 2+ can induce the proliferation and migration of endothelial cells through the G protein-coupled receptor pathway during vascularization . In this study, the proliferation results exhibit concentration-dependent cellular behavior, and the vitality and proliferation capability of MC3T3-E1 and HUVECs cells increase with the decrease of ions released in the coating.…”

Section: Resultsmentioning

confidence: 74%

“…65,66 Mg 2+ can induce the proliferation and migration of endothelial cells through the G protein-coupled receptor pathway during vascularization. 67 In this study, the proliferation results exhibit concentration-dependent cellular behavior, and the vitality and proliferation capability of MC3T3-E1 and HUVECs cells increase with the decrease of ions released in the coating. The CA-MP coating has a lower Mg 2+ release rate and better osteogenic induction ability, while the SN-MP sample exhibits a higher Mg 2+ release rate and lower HUVECs vitality, which may be attributed to the loss of self-renewal ability.…”

Section: Biocompatibility Evaluationmentioning

confidence: 63%

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Construction of Magnesium Phosphate Chemical Conversion Coatings with Different Microstructures on Titanium to Enhance Osteogenesis and Angiogenesis

Li,

Zhang,

et al. 2024

ACS Appl. Mater. Interfaces

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Titanium (Ti) and its alloys are widely used as hard tissue substitutes in dentistry and orthopedics, but their low bioactivity leads to undesirable osseointegration defects in the early osteogenic phase. Surface modification is an important approach to overcome these problems. In the present study, novel magnesium phosphate (MgP) coatings with controllable structures were fabricated on the surface of Ti using the phosphate chemical conversion (PCC) method. The effects of the microstructure on the physicochemical and biological properties of the coatings on Ti were researched. The results indicated that accelerators in PCC solution were important factors affecting the microstructure and properties of the MgP coatings. In addition, the coated Ti exhibited excellent hydrophilicity, high bonding strength, and good corrosion resistance. Moreover, the biological results showed that the MgP coatings could improve the spread, proliferation, and osteogenic differentiation of mouse osteoblast cells (MC3T3-E1) and vascular differentiation of human umbilical vein endothelial cells (HUVECs), indicating that the coated Ti samples had a great effect on promoting osteogenesis and angiogenesis. Overall, this study provided a new research idea for the surface modification of conventional Ti to enhance osteogenesis and angiogenesis in different bone types for potential biomedical applications.

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Section: Resultsmentioning

confidence: 74%

Section: Biocompatibility Evaluationmentioning

confidence: 63%

Construction of Magnesium Phosphate Chemical Conversion Coatings with Different Microstructures on Titanium to Enhance Osteogenesis and Angiogenesis

Li,

Zhang,

et al. 2024

ACS Appl. Mater. Interfaces

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“…Titanium implants are widely used to restore lost teeth and plenty of studies focusing on the surface modification of titanium have been conducted to improve the osseointegration of dental implants. 169–171 As for SSR strategies applied to dental implants, Pourhajibagher et al 91 reported an ex vivo study on the application of SDT, simultaneously with PDT, to inhibit polymicrobial periopathogenic biofilms on titanium dental implant surfaces. In this study, indocyanine green (ICG) was employed as the photostimulation-sonosensitizer, which displayed synergistic anti-biofilm effect under NIR light and US stimulation.…”

Section: External Stimuli-responsive Strategiesmentioning

confidence: 99%

Smart stimuli-responsive strategies for titanium implant functionalization in bone regeneration and therapeutics

Zhang,

Zhuang,

Sheng

et al. 2024

Mater. Horiz.

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“…Integrin binding is a molecular function that was enriched in 11 differential proteins. Magnesium ions promote cell attachment through binding interactions between the integrin family and FAK-related signaling pathways (36).…”

Section: Molecular Functional Analysis Of Differentially Expressed Pr...mentioning

confidence: 99%

Changes in the urinary proteome of rats after short-term intake of magnesium L-threonate(MgT)

Shen,

Yang,

Wang

et al. 2023

Front. Nutr.

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IntroductionMagnesium (Mg) is an important mineral in living organisms. Magnesium has multiple functions in the human body, wherein it plays an important therapeutic and preventive role in a variety of diseases.MethodsUrine samples of rats before and after gavage of magnesium L-threonate (MgT) were collected, and the urinary proteome was identified using the LC-MS/MS technique and analyzed using various databases.Results and discussionThe results illustrated that the urinary proteome of rats was significantly altered after short-term intake of magnesium supplements and that the differential proteins and the biological functions were related to magnesium. This study innovatively establishes a method to study nutrients from the perspective of urine proteomics. This work demonstrates that the urinary proteome is capable of reflecting the effects of nutrient intake on the organism in a more systematic and comprehensive manner and has the potential to provide clues for clinical nutrition research and practice.

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Surface modification of titanium implants with Mg-containing coatings to promote osseointegration

Cited by 23 publications

References 77 publications

Construction of Magnesium Phosphate Chemical Conversion Coatings with Different Microstructures on Titanium to Enhance Osteogenesis and Angiogenesis

Construction of Magnesium Phosphate Chemical Conversion Coatings with Different Microstructures on Titanium to Enhance Osteogenesis and Angiogenesis

Smart stimuli-responsive strategies for titanium implant functionalization in bone regeneration and therapeutics

Changes in the urinary proteome of rats after short-term intake of magnesium L-threonate(MgT)

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