Surface Modification of Spherical Particles with Bioactive Glycopolymers

Pfaff, André

doi:10.1021/bk-2012-1101.ch017

Cited by 1 publication

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References 70 publications

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“…N-methyl-d-glucamine and different glucose-and glucosamine-based acrylamide or (meth)acrylate monomers [30,33,43,[45][46][47][48][49][50][51], (Figure 4), either in their linear or ring form, have been synthesized and used for the preparation of well-defined polymer brushes by RDRP methods. The resultant materials have been extensively studied mainly for the specific binding and recognition by lectins [22,24,25,38,39,41,48,49,[51][52][53][54][55][56][57][58]. Very hydrophilic poly(2′-acrylamidoethyl-α-ᴅ-mannopyranoside) (PAAEM), poly(2′acrylamidoethyl-β-ᴅ-galactopyranoside) (PAAEGal) and poly(2′-acrylamidoethyl-β-ᴅglucopyranoside) (PAAEGlc) brushes, prepared by SI-ATRP from silicon substrates in water, exhibited a 149-, 172-, and 500-fold reduction of the non-specific adsorption of bovine serum albumin (BSA), respectively, as well as a 52-, 115-, and 135-fold fibrinogen (Fb) adsorption, respectively, in comparison to uncoated silicone surface [38].…”

Section: Glucose-containing Polymer Brushesmentioning

confidence: 99%

Glycopolymer Brushes by Reversible Deactivation Radical Polymerization: Preparation, Applications, and Future Challenges

et al. 2020

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The cellular surface contains specific proteins, also known as lectins, that are carbohydrates receptors involved in different biological events, such as cell–cell adhesion, cell recognition and cell differentiation. The synthesis of well-defined polymers containing carbohydrate units, known as glycopolymers, by reversible deactivation radical polymerization (RDRP) methods allows the development of tailor-made materials with high affinity for lectins because of their multivalent interaction. These polymers are promising candidates for the biomedical field, namely as novel diagnostic disease markers, biosensors, or carriers for tumor-targeted therapy. Although linear glycopolymers are extensively studied for lectin recognition, branched glycopolymeric structures, such as polymer brushes can establish stronger interactions with lectins. This specific glycopolymer topology can be synthesized in a bottlebrush form or grafted to/from surfaces by using RDRP methods, allowing a precise control over molecular weight, grafting density, and brush thickness. Here, the preparation and application of glycopolymer brushes is critically discussed and future research directions on this topic are suggested.

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