Surface Modification of Resorcinarene-Based Self-Assembled Solid Lipid Nanoparticles for Drug Targeting

Das, Sanjoy; Das, Malay Kumar

doi:10.1007/978-3-030-06115-9_16

Cited by 7 publications

(8 citation statements)

References 101 publications

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“…Owing to the smaller size and larger surface area, SLN-based DDS shows increase solubility and improved bioavailability. 78 , 79 Furthermore, owing to the property of crossing the blood-brain barrier (BBB), SLN moved into the central nervous system and trapped by the cells more efficiently than larger molecules and, therefore, could be used as effective transport and delivery systems. 80 Bartsch et al reported that SLNs could work as an efficient drug delivery system to deliver antisense oligonucleotide (AS-ODN) to liver endothelial cells in-vitro and in-vivo by stabilized lipid-coated lipoplexes.…”

Section: Various Types Of Nanocarrier-based Drug Delivery Systemsmentioning

confidence: 99%

Nanocarriers-Mediated Drug Delivery Systems for Anticancer Agents: An Overview and Perspectives

Edis¹,

Wang²,

Waqas³

et al. 2021

IJN

162

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Nanotechnology has been actively integrated as drug carriers over the last few years to treat various cancers. The main hurdle in the clinical management of cancer is the development of multidrug resistance against chemotherapeutic agents. To overcome the limitations of chemotherapy, the researchers have been developing technological advances for significant progress in the oncotherapy by enabling the delivery of chemotherapeutic agents at increased drug content levels to the targeted spots. Several nano-drug delivery systems designed for tumor-targeting are evaluated in preclinical and clinical trials and showed promising outcomes in cancerous tumors’ clinical management. This review describes nanocarrier’s importance in managing different types of cancers and emphasizing nanocarriers for drug delivery and cancer nanotherapeutics. It also highlights the recent advances in nanocarriers-based delivery systems, including polymeric nanocarriers, micelles, nanotubes, dendrimers, magnetic nanoparticles, solid lipid nanoparticles, and quantum dots (QDs). The nanocarrier-based composites are discussed in terms of their structure, characteristics, and therapeutic applications in oncology. To conclude, the challenges and future exploration opportunities of nanocarriers in chemotherapeutics are also presented.

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Section: Various Types Of Nanocarrier-based Drug Delivery Systemsmentioning

confidence: 99%

Nanocarriers-Mediated Drug Delivery Systems for Anticancer Agents: An Overview and Perspectives

Edis¹,

Wang²,

Waqas³

et al. 2021

IJN

162

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“…A wide variety of aldehydes have been used in the preparation of resorcinarenes, including saturated alkyl aldehydes, unsaturated alkyl aldehydes, and sulfur-containing aldehydes (Table ). These functionalized aldehydes lead to the construction of resorcinarenes that have various bottom edge functionalities. …”

Section: Polyhydroxylated Platforms (Calixarenes/resorcinarenes)mentioning

confidence: 99%

“…These functionalized aldehydes lead to the construction of resorcinarenes that have various bottom edge functionalities. 24 …”

Section: Polyhydroxylated Platforms (Calixarenes/resorcinarenes)mentioning

confidence: 99%

Copper(I)-Catalyzed Alkyne–Azide Cycloaddition (CuAAC) “Click” Reaction: A Powerful Tool for Functionalizing Polyhydroxylated Platforms

2023

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Click chemistry is currently one of the most used tools for the generation of complex organic molecules. The advantages of using click chemistry in organic synthesis are remarkable; in many cases, the reactions occur under mild conditions and are free of solvents, with high yields and short reaction times. This makes it an extraordinarily effective and viable alternative for obtaining complex/conjugated molecules. In this review, the use of click chemistry CuAAC is especially emphasized for polyhydroxylated platforms such as resorcinarenes or calixarenes, focusing mainly on aspects of synthesis, specifically conditions, reagents, and methodologies.

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“…Biomolecules such as peptides, 352 proteins, 383 nucleic acids, 384,385 viruses, 386 enzymes, 387 and lipids 388 can assemble to produce nanostructured materials. Assembled biomolecules are used for surface modification, 389,390 biomineralization, 391 tissue engineering, 392 and drug delivery. 303,393,394 TEM is capable of directly probing the interactions that govern these assemblies as well as the final assembled structures.…”

Section: Biomoleculesmentioning

confidence: 99%

“…Biomolecules such as peptides, proteins, nucleic acids, , viruses, enzymes, and lipids can assemble to produce nanostructured materials. Assembled biomolecules are used for surface modification, , biomineralization, tissue engineering, and drug delivery. ,, TEM is capable of directly probing the interactions that govern these assemblies as well as the final assembled structures. However, monitoring these self-assembly mechanisms with TEM can be challenging due to the weak binding among biomolecules, which can be easily damaged by the electron beam, as well as poor sample contrast .…”

Section: Tem Of Different Materials Classesmentioning

confidence: 99%

A Close Look at Molecular Self-Assembly with the Transmission Electron Microscope

et al. 2021

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Molecular self-assembly is pervasive in the formation of living and synthetic materials. Knowledge gained from research into the principles of molecular self-assembly drives innovation in the biological, chemical, and materials sciences. Self-assembly processes span a wide range of temporal and spatial domains and are often unintuitive and complex. Studying such complex processes requires an arsenal of analytical and computational tools. Within this arsenal, the transmission electron microscope stands out for its unique ability to visualize and quantify self-assembly structures and processes. This review describes the contribution that the transmission electron microscope has made to the field of molecular self-assembly. An emphasis is placed on which TEM methods are applicable to different structures and processes and how TEM can be used in combination with other experimental or computational methods. Finally, we provide an outlook on the current challenges to, and opportunities for, increasing the impact that the transmission electron microscope can have on molecular self-assembly.

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Surface Modification of Resorcinarene-Based Self-Assembled Solid Lipid Nanoparticles for Drug Targeting

Cited by 7 publications

References 101 publications

Nanocarriers-Mediated Drug Delivery Systems for Anticancer Agents: An Overview and Perspectives

Nanocarriers-Mediated Drug Delivery Systems for Anticancer Agents: An Overview and Perspectives

Copper(I)-Catalyzed Alkyne–Azide Cycloaddition (CuAAC) “Click” Reaction: A Powerful Tool for Functionalizing Polyhydroxylated Platforms

A Close Look at Molecular Self-Assembly with the Transmission Electron Microscope

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