Surface modification of polyurethane via covalent immobilization of sugar-based trisiloxane surfactants

Abstract

Sugar-based trisiloxane surfactants (N-siloxanegluconamides and N-siloxanelactobionamides, denoted as Si(3)NGA and Si(3)NLA) with the amphiphilic structures were successfully prepared. Polyurethane (PU) was grafted with 2-carboxyethyl acrylate (CEA) by the means of UV-induced graft polymerization, and further introduction of the Si(3)NGA and Si (3)NLA by conjugating the amino groups and acid groups. The surface graft polymerization was confirmed by attenuated total reflection Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy, respectively. Water contact angle, protein adsorption, and platelet adhesion measurements were used to evaluate the hydrophilicity and hemocompatibility of the films. It was found that the Si(3)NGA-modified substrates obviously suppressed protein adsorption and platelet adhesion, while Si(3)NLA-modified substrates exhibited a higher protein adsorption and a coagulating performance of blood.

Self-Assembly of Amphiphilic Compounds as a Versatile Tool for Construction of Nanoscale Drug Carriers

“…The presence of a lactose moiety in the molecule provides both industrial and biotechnological significance to these compositions. These compounds could be used as efficient micellar catalysts of Ullmann C-S coupling reactions in water (the yield of product could reach 90% by selecting an appropriate alkyl tail length) [ 59 ]; highly-effective antibacterial agents against a wide spectrum of microorganisms [ 60 ]; coatings interrupting undesired adsorption processes [ 61 ]; compounds for condensation with DNA, that could be accurately tuned by selection of the counterion [ 62 ]; a basis of a vehicle for ketoprofen delivery [ 63 ]. Maltose and sucrose amphiphilic derivatives were recommended as components of microemulsions—potential alternative fuel [ 64 ], regulators of wettability of various solid surfaces like quartz and polyethylene [ 65 ] and modifiers of adsorption parameters at the air/liquid interface of systems [ 66 ].…”