Surface modification of polymers by ion implantation for biocompatible materials: relations of platelet adhesion to irradiation effects

Xu, Guochun; Hibino, Yutaka; Suzuki, Yoshiaki; Tanihara, Masao; Imanishi, Y.

doi:10.1109/iit.1998.813885

Cited by 1 publication

(3 citation statements)

References 2 publications

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“…Similarly, implantation of PUR or polyethersulphone with Ar at 35 keV and doses between 10 10 and 10 16 ions/cm 2 led to a specific drop in contact angles and thus significantly improved adhesion of HUVECs on both polymers 28. Bombardment of segmented polyurethane N, O, or He ions at 1 or 100 keV and ion doses of 10 14 to 10 16 ions/cm 2 also decreases contact angles, but reduces platelet adhesion 29…”

Section: Discussionmentioning

confidence: 95%

Biological relevance of ion energy in performance of human endothelial cells on ion‐implanted flexible polyurethane surfaces

Özkucur

Richter

Wetzel

et al. 2009

J Biomedical Materials Res

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To improve the biocompatibility of polyurethane (PUR), we modified the surface by irradiation with different ions (Carbon; C, Oxygen; O, Nitrogen; N, or Argon; Ar) at 0.3-50 keV energy and doses of 1,00E+13 - 1,00E+15 ions/cm(2). The effects of ion implantation using different ion energies and densities were observed on adhesion, proliferation, and viability of human umbilical vein endothelial cells (HUVECs). The long-term in vitro stability of ion-implanted PUR was also investigated. Ion irradiation moderately affected the surface roughness (R(a)), but strongly enhanced the work of adhesion (W(a)). Cell adhesion was markedly improved on O-, N-, and Ar-, but not on C-implanted PUR surfaces. Medium ion energies and lower ion doses produced the best HUVEC attachment and proliferation, indicating the importance of choosing the proper range of energy applied during ion irradiation. In addition, apoptosis rates were significantly reduced when compared with unmodified PUR (uPUR). N implantation significantly protected the surface, although C implantation led to stronger surface erosions than on uPUR. In total, ion implantation on flexible PUR surfaces strongly improved the material surface characteristics and biocompatibility. Electron beam ion implantation within an appropriate energy window is thus a key to improving flexible PUR surfaces for clinical use to support endothelial cell performance. Thus, it can contribute to designing small-diameter grafts, which are in great demand, towards vascular tissue engineering applications.

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Section: Discussionmentioning

confidence: 95%

Biological relevance of ion energy in performance of human endothelial cells on ion‐implanted flexible polyurethane surfaces

Özkucur

Richter

Wetzel

et al. 2009

J Biomedical Materials Res

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“…The extensive study on nitrogen implantation was done. Nitrogen was implanted in polymers and various biomaterials for different applications [8][9][10][11][12][13]. Nitrogen was implanted in Titanium, NiTi [8,14,15], and SS316L as well [12,16].…”

Section: Introductionmentioning

confidence: 99%

“…Implantation of helium also attracts considerable attention of the researchers. Helium ions were implanted in polymers [8,10,11,17] and metals [18]. Kripton was implanted in Ti-6Al-4V alloy [19].…”

Section: Introductionmentioning

confidence: 99%

Experimental Evaluation of Corrosion and Hardness on AISI 316l Stainless Steel Implanted with Nitrogen and Argon Ions

Muthukumaran¹,

Selladurai²,

Reghuraj³

et al. 2010

AMS

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In this work the AISI 316L SS was implanted with two different ions namely nitrogen and argon separately at 100 KeV with fluence of 1x1017ions/cm² at room temperature. The crystallographic orientation and surface morphology were studied using X-ray Diffraction (XRD) and Scanning Electron Microscope (SEM). The effects of ion implantation, on the corrosion performance of AISI316L stainless steel were evaluated. Microhardness was also measured by Vickers method by varying the loads. The results of the studies indicated that there was a significant improvement in both corrosion and hardness in the case of implanted samples.

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Surface modification of polymers by ion implantation for biocompatible materials: relations of platelet adhesion to irradiation effects

Cited by 1 publication

References 2 publications

Biological relevance of ion energy in performance of human endothelial cells on ion‐implanted flexible polyurethane surfaces

Biological relevance of ion energy in performance of human endothelial cells on ion‐implanted flexible polyurethane surfaces

Experimental Evaluation of Corrosion and Hardness on AISI 316l Stainless Steel Implanted with Nitrogen and Argon Ions

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