Surface Modification of Polymers by using Excimer Laser for Biomedical Applications

Jäger, Maria; Sonntag, Frank; Pietzsch, Marcus; Poll, R.; Rabenau, M.

doi:10.1002/ppap.200731011

Cited by 10 publications

(5 citation statements)

References 6 publications

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“…Such changes in the properties caused by the laser treatment result in an increased adhesion and proliferation of mammalian cells [32]. On PS, for example, the density of the cells on the modified surfaces increases with the duration of the laser treatment to a certain point, where a peak of density roughly 1.9 times greater than that observed on a pristine substrate is reached after 60 s at the fluence of 12.5 mJ/cm 2 [33]. Increasing the treatment duration further leads to a decrease in the number of adhered cells, which indicates that an excessive number of new functional groups introduced to the surface is contra productive for cell adhesion and proliferation.…”

Section: Laser Treatmentmentioning

confidence: 99%

Surface Modification of Polymer Substrates for Biomedical Applications

2017

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While polymers are widely utilized materials in the biomedical industry, they are rarely used in an unmodified state. Some kind of a surface treatment is often necessary to achieve properties suitable for specific applications. There are multiple methods of surface treatment, each with their own pros and cons, such as plasma and laser treatment, UV lamp modification, etching, grafting, metallization, ion sputtering and others. An appropriate treatment can change the physico-chemical properties of the surface of a polymer in a way that makes it attractive for a variety of biological compounds, or, on the contrary, makes the polymer exhibit antibacterial or cytotoxic properties, thus making the polymer usable in a variety of biomedical applications. This review examines four popular methods of polymer surface modification: laser treatment, ion implantation, plasma treatment and nanoparticle grafting. Surface treatment-induced changes of the physico-chemical properties, morphology, chemical composition and biocompatibility of a variety of polymer substrates are studied. Relevant biological methods are used to determine the influence of various surface treatments and grafting processes on the biocompatibility of the new surfaces—mammalian cell adhesion and proliferation is studied as well as other potential applications of the surface-treated polymer substrates in the biomedical industry.

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Section: Laser Treatmentmentioning

confidence: 99%

Surface Modification of Polymer Substrates for Biomedical Applications

2017

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“…For immobilization of bioactive compounds onto polymers, it is necessary for polymer surfaces to be functionalized. Laser treatment is a clear, fast, and effective route for functionalization of polymers 3…”

Section: Introductionmentioning

confidence: 99%

Laser‐modified nanostructures of PET films and cell behavior

Mirzadeh

Moghadam

Mivehchi

2011

J Biomedical Materials Res

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The surface of polyethylene terephthalate (PET) films was irradiated using KrF excimer laser (λ = 248 nm) with different number of pulses at constant repetition rate. The adhesion behavior of L-929 fibroblast cells on the irradiated surface was investigated. The changes in films' morphology were characterized by atomic force microscopy (AFM) and scanning electron microscopy (SEM). The hydrophilicity and both polar and dispersion components of the surface tension of the treated films were evaluated by contact angle and surface tension measurement techniques. The films roughness was evaluated by atomic force microscopy. AFM and SEM observations showed that a specific nanostructure was created on the laser-treated polyethylene terephthalate surface. Contact angle and surface energy measurements have indicated an increase in wettability of the laser treated samples up to 5 pulses as optimum result; while, by increasing the laser pulses beyond 5 pulses the hydrophilicity of laser treated samples dropped and the surface energy of the treated films was leveled off. Data from in vitro assays showed significant cell attachment and cell growth onto laser treated samples in comparison with the untreated films. Moreover, a number of fibroblast cells attached and proliferated onto treated PET films were achieved under optimum condition of 5 pulses which was significantly higher than the other treated samples.

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“…However, the structure was seriously processed when the laser fluence exceeds a certain magnitude. This is because the increase in laser fluence at a constant scanning speed generated a higher ratio of molten to evaporated material and created a higher temperature gradient, which caused more debris after laser ablation . This melting residue will result in lower accuracy and quality of the pattern and a potential instability for the adhesion .…”

Section: Resultsmentioning

confidence: 99%

3D printed conductive patterns based on laser irradiation

Shin

Park

2017

Physica Status Solidi (a)

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Phone: þ82 2 970 6356, Fax: þ82 2 976 5173In recent years, there has been significant interest in simple and affordable technologies that produce 3D printed embedded electronics and interconnects, in order to increase the functionality of these structures. This study describes the development of 3D printing processes for conductive patterns using 3D printing of metal particle dispersed polymer. This fabrication method is based on 3D molded interconnect device (MID) technology with laser direct structuring. The pattern on 3D printed structure is selectively activated by laser ablation and acquires high conductivity after electroless plating. The method described can be used to directly print a variety of customized and fully-functional product prototypes using a general ME (material extrusion)-type polymer 3D-printer based on laser irradiation.The schematic of the suggested manufacturing method. With proper laser processing, the surface of 3D printed substrate is selectively activated as a seed layer and acquires high conductivity after electroless plating.

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Surface Modification of Polymers by using Excimer Laser for Biomedical Applications

Cited by 10 publications

References 6 publications

Surface Modification of Polymer Substrates for Biomedical Applications

Surface Modification of Polymer Substrates for Biomedical Applications

Laser‐modified nanostructures of PET films and cell behavior

3D printed conductive patterns based on laser irradiation

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