Surface modification of polyethylene balloon catheters for local drug delivery

Richey, Tina; Iwata, Hiroo; Oowaki, Hisayuki; Uchida, Emiko; Matsuda, Shuichi; Ikada, Yoshito

doi:10.1016/s0142-9612(99)00281-1

Cited by 77 publications

(68 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Controlled drug release systems are widely employed to treat localized disease conditions in specific anatomical sites, or to control adverse local biological response to an implantable medical device (Anderson, 2003;Richey et al, 2000;Wang et al, 2007;Pires et al, 2005;Kohane, 2006), improving the performance of the treatment and reducing side-effects (Ho Wah et al, 1987). Furthermore, this kind of device allows prediction of the delivery rate, maintaining the drug concentration within the therapeutic range (Swarbrick and Boylan , 1990).…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of copolymers of methylmethacrylate and 2-hydroxyethyl methacrylate for the aqueous solubilization of Paclitaxel

et al. 2009

View full text Add to dashboard Cite

The aim of the present work is the modification of a hydrophobic polymeric macromolecule, polymethylmethacrylate, by introducing hydrophilic moieties of 2-hydroxyethyl methacrylate within the polymer chain. Synthesis, characterization, and drug delivery control capabilities exerted on a highly hydrophobic drug (Paclitaxel) are illustrated. In particular, the dependency of the drug delivery kinetic on the fraction of hydrophilic units inserted in the copolymer chain was studied. Results showed that it is possible to have an increase of the kinetic delivery introducing hydrophilic units. In addition, a double control, diffusive and due to the relaxation of the molecules, on drug delivery was obtained.

show abstract

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of copolymers of methylmethacrylate and 2-hydroxyethyl methacrylate for the aqueous solubilization of Paclitaxel

et al. 2009

View full text Add to dashboard Cite

show abstract

“…Therefore, there is much interest in the surface modification of polymers to create different and new applications. [1][2][3] Modified polymer surfaces have a number of improved properties, such as adhesion, [4][5][6] hydrophilicity, 7 antistatic nature, 8 wearability, 9,10 dyeing ability, 11 and biocompatibility. 12 The graft polymerization of monomers onto the surfaces of polymers is one of the main efficient processes for inducing modification.…”

Section: Introductionmentioning

confidence: 99%

Surface functionalization of polyolefin films via the ultraviolet‐induced photografting of acrylic acid: Topographical characterization and ability for binding antifungal agents

Costamagna¹,

Wunderlin²,

Larrañaga³

et al. 2006

J of Applied Polymer Sci

View full text Add to dashboard Cite

ABSTRACT:The photoinduced graft copolymerization of acrylic acid with ultraviolet radiation onto films of poly (vinyl chloride), polypropylene, and polyethylene was studied. Benzophenone was used as the initiator for most of the experiments performed. The percentage of grafting was determined by gravimetric measurements, and the characterization of the grafted films was carried out by chemical analysis (Fourier transform infrared spectroscopy, volumetric titration, and dye adsorption). In all samples, the grafted yield increased with the ultraviolet exposure time. High levels of grafting were obtained at room temperature. In addition, optical and atomic force microscopy allowed the topography of the modified films to be studied as a function of the reaction time. The pendant functional groups that were grafted were then used to bind antifungal agents, such as natamycin and crystal violet, and the antifungal properties of the films were demonstrated.

show abstract

“…Like water contact angle and surface titration, zeta potential can be used to determine surface isoelectric points and quantify a change in surface ionizable groups [79,80]. In developing a balloon catheter for localized drug delivery, Richey et al used zeta potential to select a polymer and surface modification technique that would best deliver the drug at blood pH (~7.4) [81]. Zeta potential can also be used to better understand microenvironment effects on bioactive compound activity at the solid-liquid interface.…”

Section: Zeta Potentialmentioning

confidence: 99%

“…Sometimes the organic components of the sample would be decomposed by the electron beam; this can be avoided using cryogenic microscopy (cryo-TEM), where the specimen is measured at liquid nitrogen or liquid helium temperatures in a frozen state. High resolution TEM (HRTEM) can afford a much closer look at the samples [81]. The recent application of electron energy loss spectroscopy imaging techniques to TEM (ESI-TEM) can provide information on the composition of polymer surfaces.…”

Section: Zeta Potentialmentioning

confidence: 99%

Physico-chemical methods for the chromatographic materials heterogeneity evaluation

Michel¹,

Sprynskyy²,

Buszewski³

2009

Annales UMCS, Chemistry

View full text Add to dashboard Cite

The characterization methods used in the analysis of the chemical structure, microstructure and morphology, as well as the physical properties, of the chromatographic support are varied. This paper will focus on some techniques often used for the investigation of polymer/silica stationary phases. Many of these techniques are specific for characterization of particular properties of phases, and the properties of phases are also discussed correspondingly. To fully understand structure-property relationships, several characterization techniques are presented.

show abstract

Surface modification of polyethylene balloon catheters for local drug delivery

Cited by 77 publications

References 33 publications

Synthesis and characterization of copolymers of methylmethacrylate and 2-hydroxyethyl methacrylate for the aqueous solubilization of Paclitaxel

Synthesis and characterization of copolymers of methylmethacrylate and 2-hydroxyethyl methacrylate for the aqueous solubilization of Paclitaxel

Surface functionalization of polyolefin films via the ultraviolet‐induced photografting of acrylic acid: Topographical characterization and ability for binding antifungal agents

Physico-chemical methods for the chromatographic materials heterogeneity evaluation

Contact Info

Product

Resources

About