Surface Modification of PLLA, PTFE and PVDF with Extreme Ultraviolet (EUV) to Enhance Cell Adhesion

Abstract

Recently, extreme ultraviolet (EUV) radiation has been increasingly used to modify polymers. Properties such as the extremely short absorption lengths in polymers and the very strong interaction of EUV photons with materials may play a key role in achieving new biomaterials. The purpose of the study was to examine the impact of EUV radiation on cell adhesion to the surface of modified polymers that are widely used in medicine: poly(tetrafluoroethylene) (PTFE), poly (vinylidene fluoride) (PVDF), and poly-L-(lactic acid) (PLLA). After EUV surface modification, which has been performed using a home-made laboratory system, changes in surface wettability, morphology, chemical composition and cell adhesion polymers were analyzed. For each of the three polymers, the EUV radiation differently effects the process of endothelial cell adhesion, dependent of the parameters applied in the modification process. In the case of PVDF and PTFE, higher cell number and cellular coverage were obtained after EUV radiation with oxygen. In the case of PLLA, better results were obtained for EUV modification with nitrogen. For all three polymers tested, significant improvements in endothelial cell adhesion after EUV modification have been demonstrated.

Effect of Extreme Ultraviolet (EUV) Radiation and EUV Induced, N2 and O2 Based Plasmas on a PEEK Surface’s Physico-Chemical Properties and MG63 Cell Adhesion

“…Also, the presence of that group was not demonstrated in materials modified in the presence of nitrogen gas. Similar results were obtained in our previous studies on modifying other polymers (PTFE, PLLA, PVDF) [39]. In the study, we also observed lower WCA values for surfaces modified in an oxygen atmosphere compared to those modified in a nitrogen atmosphere.…”

“…It is worth noting that the C-OH groups were not present in Also, the presence of that group was not demonstrated in materials ence of nitrogen gas. Similar results were obtained in our previous s other polymers (PTFE, PLLA, PVDF) [39]. In the study, we also o In our study, the modification process conducted in the presence of oxygen resulted in the formation of hydrophilic C-OH groups (Table 1).…”

Biological Characterization of Polymeric Matrix and Graphene Oxide Biocomposites Filaments for Biomedical Implant Applications: A Preliminary Report

“…Several studies report PLLA activity related to cell adhesion [ 59 , 60 ]. In addition to cell adhesion proofing, Yanagida et al [ 61 ] for instance, verified the response to PLLA tissue coated with hydroxyapatite nanocrystal (HAp).…”

Histologic and Histomorphometric Evaluation of a New Bioactive Liquid BBL on Implant Surface: A Preclinical Study in Foxhound Dogs

“…The use of liquid bioactive material improves implant wettability and influences the early stages of osteointegration. However, the reactivity of liquid bioactive surfaces is dependent on their hydrophilic competency, salt composition and concertation, electrodynamic charge, lack of solid components, and proteins, factors that may influence viscosity, stiffness, and roughness [ 29 , 48 , 49 ]. Anitua et al’s innovative work using titanium implants pre-treated with liquid PRGF proved that the implants accelerate bone regeneration, reduce post-extraction defects, and thus, shorten the time between tooth extraction and implant insertion [ 34 , 35 , 36 , 38 , 50 , 51 ].…”