Surface modification of plasmonic noble metal–metal oxide core–shell nanoparticles

Talebzadeh, Somayeh; Queffélec, Clémence; Knight, D. Andrew

doi:10.1039/c9na00581a

Cited by 31 publications

(10 citation statements)

References 158 publications

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“…Because of the variety of silane reagents available for click chemistry, the silane linker is condensed on the silica shell surface through an alkoxysilane group, allowing the targeting ligand to be easily coupled to the particles. [ 45 ] In addition, the loading and release of drugs can be easily controlled through surface modification. Surface functionalization is usually required to load appropriate drug molecules onto NPs (hydrophobic/hydrophilic or positive/negative charges).…”

Section: Advantages Of Silica‐coated Aunrs For Biomedical Applicationsmentioning

confidence: 99%

Structurally Engineered Silica Shells on Gold Nanorods for Biomedical Applications

et al. 2023

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Owing to their unique optical and chemical properties, gold nanorods (AuNRs) are among the most frequently used nanomaterials for biomedical applications, including cancer therapy, imaging, and drug delivery. In particular, the longitudinal dipole plasmon wavelength of AuNRs can be verified from the visible to the near‐infrared (NIR) region, allowing AuNRs to be used as photodynamic/photothermal and imaging contrast agents. At the same time, the silica shell is important as it enhances stability and facilitates the functionalization and biocompatibility of AuNRs, offering numerous advantages in biomedical applications. In this review, silica‐coated AuNRs from a bioapplication perspective are focused. First, the importance of AuNRs for biomedical applications is explained and the purpose of silica coating on AuNRs is discussed. Then, recent studies on the development of silica‐coated AuNRs from a biomedical perspective are reviewed. Subsequently, various strategies for engineering silica coatings and their properties in the biomedical field are reviewed. This review is expected to promote further research on next‐generation silica‐coated AuNRs for biomedical applications.

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Section: Advantages Of Silica‐coated Aunrs For Biomedical Applicationsmentioning

confidence: 99%

Structurally Engineered Silica Shells on Gold Nanorods for Biomedical Applications

et al. 2023

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“…The carbodiimide coupling reaction is a conventional technique that is widely used to conjugate antibodies to the surfaces of NPs [ 22 – 24 ]. This method involves activation of the carboxyl groups on the surface of the NPs, which can then be covalently conjugated to the amine groups of the antibodies.…”

Section: Introductionmentioning

confidence: 99%

Impact of the conjugation of antibodies to the surfaces of polymer nanoparticles on the immune cell targeting abilities

et al. 2021

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Antibodies have been widely used to provide targeting ability and to enhance bioactivity owing to their high specificity, availability, and diversity. Recent advances in biotechnology and nanotechnology permit site-specific engineering of antibodies and their conjugation to the surfaces of nanoparticles (NPs) in various orientations through chemical conjugations and physical adhesions. This study proposes the conjugation of poly(lactic-co-glycolic acid) (PLGA) NPs with antibodies by using two distinct methods, followed by a comparison between the cell-targeting efficiencies of both techniques. Full-length antibodies were conjugated to the PLGA-poly(ethylene glycol)-carboxylic acid (PLGA-PEG-COOH) NPs through the conventional carbodiimide coupling reaction, and f(ab′)2 antibody fragments were conjugated to the PLGA-poly(ethylene glycol)-maleimide(PLGA-PEG-Mal) NPs through interactions between the f(ab′)2 fragment thiol groups and the maleimide located on the nanoparticle surface. The results demonstrate that the PLGA nanoparticles conjugated with the f(ab′)2 antibody fragments had a higher targeting efficiency in vitro and in vivo than that of the PLGA nanoparticles conjugated with the full-length antibodies. The results of this study can be built upon to design a delivery technique for drugs through biocompatible nanoparticles.

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“…The positioning of emitters in the plasmonic field can be achieved by binding them, either electrostatically or covalently, 38 on the surface of metal nanoparticles. The distance between the plasmonic surface and the emitters (represented as 't') decisively influences their PL characteristics which can be varied by (i) overcoating a plasmonic nanoparticle with an inert shell (e.g., silica 31,39 or a polymer 26,40 ) or (ii) functionalizing the surface with organic linkers.…”

Section: Introductionmentioning

confidence: 99%

Combined effects of emitter–emitter and emitter–plasmonic surface separations dictate photoluminescence enhancement in a plasmonic field

Thomas

Cortes

Paul

et al. 2022

Phys. Chem. Chem. Phys.

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Surface modification of plasmonic noble metal–metal oxide core–shell nanoparticles

Abstract: A comprehensive survey on methods for surface modification of noble metal–metal oxide core–shell nanoparticles is presented and highlights various strategies for binding of molecules and molecular ions to core–shell nanoparticles.

Cited by 31 publications

References 158 publications

Structurally Engineered Silica Shells on Gold Nanorods for Biomedical Applications

Structurally Engineered Silica Shells on Gold Nanorods for Biomedical Applications

Impact of the conjugation of antibodies to the surfaces of polymer nanoparticles on the immune cell targeting abilities

Combined effects of emitter–emitter and emitter–plasmonic surface separations dictate photoluminescence enhancement in a plasmonic field

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