Surface modification of pH-responsive poly(2-(tert-butylamino)ethyl methacrylate) brushes grafted on mesoporous silica nanoparticles

Alswieleh, Abdullah M.; Alshahrani, Mufleh M; Alzahrani, Khalid E.; Alghamdi, Hamdan S.; Niazy, Abdurahman A.; Alsilme, Abdulilah S.; Beagan, Abeer M.; Alsheheri, Bayan M; Alghamdi, Abdulaziz; Almeataq, Mohammed S.

doi:10.1080/15685551.2019.1699727

Cited by 24 publications

(17 citation statements)

References 40 publications

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“…5 nm. No significant differences in SEM and TEM images were observed between nonmodified and modified MSNs, which is similar to the observation reported previously [42] ( Figures 1S and 2S). Furthermore, the particle size distribution was investigated using dynamic light scattering (DLS).…”

Section: Resultssupporting

confidence: 91%

Modification of Mesoporous Silica Surface by Immobilization of Functional Groups for Controlled Drug Release

Alswieleh

2020

Journal of Chemistry

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This paper introduces the synthesis of mesoporous silica nanoparticles (MSNs) with three different groups such as amine, thiol, and sulfonic acid, along the internal surface. Trimethyl[3-(trimethoxysilyl)propyl]ammonium chloride was used to modify the external surface of the nanomaterials. Such materials allow control of the drug release from MSN pores. Multifunctional MSNs were loaded with doxycycline (Doxy) to study their capacities and uploading time. The loading profile indicates that sulfonic groups in the internal surface were the most efficient surfaces with a loading capacity of ca. 35% in 90 min in acidic media.

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Section: Resultssupporting

confidence: 91%

Modification of Mesoporous Silica Surface by Immobilization of Functional Groups for Controlled Drug Release

Alswieleh

2020

Journal of Chemistry

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Section: Methodsmentioning

confidence: 99%

“…Then, 0.25 mL (2.02 mmol) of 2-bromo-2-methylpropionyl bromide was mixed with 5 mL of DCM, added dropwise into the suspension, and allowed to react for 48 h at room temperature. The HMSN-Br nanoparticles were collected by centrifugation and washed with DCM and ethanol [38] In a typical reaction, 0.4 g of HMSN-Br, 12 mL of ethanol, and 3 mL of water were mixed and degassed with N 2 for 30 min under stirring. 2-Diethylaminoethyl methacrylate (2 mL), 0.0009 g of CuBr 2 , and 0.0067 g of BIPY were added to the mixture.…”

Section: Immobilization Of Bibb Initiator On Hmsns (Hmsn-br)mentioning

confidence: 99%

Glucosamine Modified the Surface of pH-Responsive Poly(2-(diethylamino)ethyl Methacrylate) Brushes Grafted on Hollow Mesoporous Silica Nanoparticles as Smart Nanocarrier

et al. 2020

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This work presents the synthesis of pH-responsive poly(2-(diethylamino) ethyl methacrylate) (PDEAEMA) brushes anchored on hollow mesoporous silica nanoparticles (HMSN-PDEAEMA) via a surface-initiated ARGET ATRP technique. The average size of HMSNs was ca. 340 nm, with a 90 nm mesoporous silica shell. The dry thickness of grafted PDEAEMA brushes was estimated to be ca 30 nm, as estimated by SEM and TEM. The halogen group on the surface of PDEAMA brushes was successfully derivatized with glucosamine, as confirmed by XPS. The effect of pH on the size of the hybrid nanoparticles was investigated by DLS. The size of fabricated nanoparticle decreased from ca. 950 nm in acidic media to ca. 500 nm in basic media due to the deprotonation of tertiary amine in the PDEAEMA. The PDEAEMA modified HMSNs nanocarrier was efficiently loaded with doxorubicin (DOX) with a loading capacity of ca. 64%. DOX was released in a relatively controlled pH-triggered manner from hybrid nanoparticles. The cytotoxicity studies demonstrated that DOX@HMSN-PDEAEMA-Glucosamine showed a strong ability to kill breast cancer cells (MCF-7 and MCF-7/ADR) at low drug concentrations, in comparison to free DOX.

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“…Despite the potential advantages of MSNs for drug delivery applications, pure MSNs tend to aggregate when directly exposed to biological environments, leading to uncontrolled drug release patterns [ 19 , 20 ]. These drawbacks could be minimized by using biocompatible polymers to coat the surface of silica nanoparticles in order to form different structures such as yolk–shell [ 21 ], core–shell [ 22 ], and brushes [ 23 ]. The combination of such polymers and silica nanoparticles not only addresses the aforementioned limitations but can also endow these particles with encapsulated guest molecules and subsequently release them at a later stage in an optimal way [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

“…Alswieleh et al successfully incorporated poly(2-(tert-butylamino)ethyl methacrylate) brushes into mesoporous silica nanoparticles via surface-initiated atom transfer radical polymerization (SI-ATRP). The results showed that the polymer brushes were highly swollen when they became protonated at a low pH value and collapsed when deprotonated at pH above 7.5 [ 23 ]. Beagan et al modified the surface of hollow mesoporous silica nanoparticles with glucosamine-poly(2-(diethylamino) ethyl methacrylate) brushes.…”

Section: Introductionmentioning

confidence: 99%

Poly(oligo(ethylene glycol) methyl ether methacrylate) Capped pH-Responsive Poly(2-(diethylamino)ethyl methacrylate) Brushes Grafted on Mesoporous Silica Nanoparticles as Nanocarrier

et al. 2021

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In this paper, a new pH-responsive nanosystem based on mesoporous silica nanoparticles (MSNs) was developed for cancer therapy. Poly(2-(diethylamino) ethyl methacrylate) (PDEAEMA) was grafted on their outer surface and acts as a gatekeeper, followed by subsequent modification of the polymer by cysteine (MSN-PDEAEMA-Cys) and poly(oligo(ethylene glycol) methyl ether methacrylate) (MSN-PDEAEMA-Cys-POEGMEMA). The physicochemical properties of these nanocarriers were characterized using scanning and transmission electron microscopies (SEM and TEM), Fourier-transform infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS), and dynamic light scattering (DLS). The synthesized nanoparticles were well-dispersed with a diameter of ca. 200 nm. The obtained XPS results confirm the successful modification of MSN-PDEAEMA with Cys and POEGMEMA by increasing the peak intensity of C–O and C=O groups at 286.5 and 288.5 eV, respectively. An anti-cancer drug, doxorubicin (DOX), was encapsulated into the fabricated nanoplatform. The DOX release amount at physiological pH of 7.4 was limited (10%), while an accumulation drug release of ca. 35% was accomplished after 30 h in acidic media. The MTT cell line was used to assess the cytotoxicity of the unloaded and DOX-loaded fabricated nanoplatforms. Upon loading of DOX on these nanomaterials, they showed significant toxicity to human liver cancer cells. These results suggest that the prepared nano-structured materials showed good biocompatibility as well, and they can serve as nanocarriers for the delivery of anti-cancer drugs.

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Surface modification of pH-responsive poly(2-(tert-butylamino)ethyl methacrylate) brushes grafted on mesoporous silica nanoparticles

Abstract: (2019) Surface modification of pH-responsive poly(2-(tert-butylamino)ethyl methacrylate) brushes grafted on mesoporous silica nanoparticles,

Cited by 24 publications

References 40 publications

Modification of Mesoporous Silica Surface by Immobilization of Functional Groups for Controlled Drug Release

Modification of Mesoporous Silica Surface by Immobilization of Functional Groups for Controlled Drug Release

Glucosamine Modified the Surface of pH-Responsive Poly(2-(diethylamino)ethyl Methacrylate) Brushes Grafted on Hollow Mesoporous Silica Nanoparticles as Smart Nanocarrier

Poly(oligo(ethylene glycol) methyl ether methacrylate) Capped pH-Responsive Poly(2-(diethylamino)ethyl methacrylate) Brushes Grafted on Mesoporous Silica Nanoparticles as Nanocarrier

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