Surface modification of nanofibrous matrices via layer-by-layer functionalized silk assembly for mitigating the foreign body reaction

Qian, Yuna; Li, Linhao; Song, Yang; Dong, Lili; Chen, Peixing; Li, Xiaoming; Cai, Kaiyong; Germershaus, Oliver; Yang, Li; Fan, Yubo

doi:10.1016/j.biomaterials.2018.02.038

Cited by 82 publications

(51 citation statements)

References 64 publications

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“…To this end, Qian et al prepared heparin disaccharide (HD)‐modified nanofibrous scaffolds with combined surface treatment by the LBL assembly approach and click chemistry technique to regulate the foreign body reactions to nanofibrous substrates for tissue engineering purposes. The PCL nanofibers were manufactured and functionalized using the LBL self‐assembly technique with SF ( Figure ) . To induce β‐sheet formation, PCL nanofibers were treated with methanol and nitrogen gas.…”

Section: Surface Modification Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Controlling Cell Behavior through the Design of Biomaterial Surfaces: A Focus on Surface Modification Techniques

Amani

Arzaghi

Bayandori

et al. 2019

Adv Materials Inter

306

200

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Surface interaction at the biomaterial–cell interface is essential for a variety of cellular functions, such as adhesion, proliferation, and differentiation. Nevertheless, changes in the biointerface enable to trigger specific cell signaling and result in different cellular responses. In order to manufacture biomaterials with higher functionality, biomaterials containing immobilized bioactive ligands have been widely introduced and employed for tissue engineering and regenerative medicine applications. Moreover, a number of physical and chemical strategies have been used to improve the functionality of biomaterials and specifically at the material interface. Here, the interactions between materials and cells at the interface levels are described. Then, the importance of surface properties in cell function is discussed and recent methods for surface modifications are systematically highlighted. Additionally, the impact of bulk material properties on the cellular responses is briefly reviewed.

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Section: Surface Modification Methodsmentioning

confidence: 99%

“…Then, treated fibers were chemically modified with HD using EDC/NHS. The authors generally observed that IL‐4 molecules were strongly adsorbed onto the surface of HD‐modified nanofiber and their sustained release induced macrophage polarization toward M 2 macrophages and resulted in anti‐inflammatory responses …”

Section: Surface Modification Methodsmentioning

confidence: 99%

Controlling Cell Behavior through the Design of Biomaterial Surfaces: A Focus on Surface Modification Techniques

Amani

Arzaghi

Bayandori

et al. 2019

Adv Materials Inter

306

200

View full text Add to dashboard Cite

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“…[45] We believe that the highly hydrophilic nature of high MW HA doped-PPy/HA surfaces controls the non-cell adhesive properties by preventing protein adsorption and/or denaturation which subsequently leads to cell adhesion. [46,47] Note that previous studies with PPy/HA, carried out by other groups, reported generally good adhesion and growth on the PPy/HA substrates; however, these studies did not explore the effects of MWs of HA dopants in PPy/HA (and in certain cases the MW of the HA used was not reported). In this study, we successfully demonstrate that cell adhesion and proliferation on conductive PPy can be simply and effectively modulated by selecting the MW of HA used in the PPy/HA films.…”

Section: In Vitro Cell Culture On the Ppy/ha Substratesmentioning

confidence: 99%

Versatile biomimetic conductive polypyrrole films doped with hyaluronic acid of different molecular weights

Kim

Jang

et al. 2018

Acta Biomaterialia

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Electrically conductive polypyrrole (PPy) is an intriguing biomaterial capable of efficient electrical interactions with biological systems. Especially, biomimetic PPy-based biomaterials incorporating biomolecules such as hyaluronic acid (HA), can impart the characteristic biological interactions with living cells/tissues to the conductive biomaterials. Here we report the effects of the molecular weight (MW) of HA on PPy-based biomaterials. We utilized HA of a wide range of MW (35 × 10 3 Da-3 × 10 6 Da) as dopants during the electrochemical production of PPy/HA films and their characterization of materials and cellular interactions. With increases in the MWs of HA dopants, PPy/HA exhibited more hydrophilic, higher electrochemical activity and lower impedance. In vitro studies revealed that PPy films doped with low MW HA were supportive to cell adhesion and growth, while PPy films doped with high MW HA were resistant to cell attachment. Subcutaneous implantation of the PPy/HA films for 4 weeks revealed that all the PPy/HA films were tissue compatible. We successfully demonstrate the importance of HA dopant MWs in modulating the chemical and electrical properties of the materials and cellular responses to the materials. Such materials have potential for various biomedical applications, including as tissue scaffolds for tissue engineering scaffolds and as electrodes for neural recording and neuromodulation.

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“…b) Immunofluorescence image showing specific adsorption of IL‐4 on a silk fibroin–functionalized PCL nanofiber and IL‐4 incorporated scaffold showing more M2 phenotypic macrophage adhesion when implanted in a subcutaneous model. Reproduced with permission . Copyright 2018, Elsevier.…”

Section: Immune Responses and Immunomodulation By Biomaterialsmentioning

confidence: 99%

“…Significant efforts have also been made to modify the synthetic biomaterial substrates with biological properties such as anti‐inflammatory drugs or cytokines for delivering at injury site or in a surface coated form. For example, silk fibroin–functionalized electrospun PCL nanofibers have been decorated with anti‐inflammatory cytokine IL‐4 by a layer‐by layer assembly, and the modified nanofiber promoted the M2 macrophage polarization in a murine subcutaneous model (Figure b) . Silicon neural probes coated with an anti‐inflammatory drug, dexamethasone, reduced the inflammatory response in a rat brain model and improved the astroglial response with the prevention of the neuronal loss .…”

Section: Immune Responses and Immunomodulation By Biomaterialsmentioning

confidence: 99%

Current Advances in Immunomodulatory Biomaterials for Bone Regeneration

Lee

Byun

Perikamana

et al. 2018

Adv Healthcare Materials

321

267

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Biomaterials with suitable surface modification strategies are contributing significantly to the rapid development of the field of bone tissue engineering. Despite these encouraging results, utilization of biomaterials is poorly translated to human clinical trials potentially due to lack of knowledge about the interaction between biomaterials and the body defense mechanism, the “immune system”. The highly complex immune system involves the coordinated action of many immune cells that can produce various inflammatory and anti‐inflammatory cytokines. Besides, bone fracture healing initiates with acute inflammation and may later transform to a regenerative or degenerative phase mainly due to the cross‐talk between immune cells and other cells in the bone regeneration process. Among various immune cells, macrophages possess a significant role in the immune defense, where their polarization state plays a key role in the wound healing process. Growing evidence shows that the macrophage polarization state is highly sensitive to the biomaterial's physiochemical properties, and advances in biomaterial research now allow well controlled surface properties. This review provides an overview of biomaterial‐mediated modulation of the immune response for regulating key bone regeneration events, such as osteogenesis, osteoclastogenesis, and inflammation, and it discusses how these strategies can be utilized for future bone tissue engineering applications.

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Surface modification of nanofibrous matrices via layer-by-layer functionalized silk assembly for mitigating the foreign body reaction

Cited by 82 publications

References 64 publications

Controlling Cell Behavior through the Design of Biomaterial Surfaces: A Focus on Surface Modification Techniques

Controlling Cell Behavior through the Design of Biomaterial Surfaces: A Focus on Surface Modification Techniques

Versatile biomimetic conductive polypyrrole films doped with hyaluronic acid of different molecular weights

Current Advances in Immunomodulatory Biomaterials for Bone Regeneration

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