Surface Modification of Multipass Caliber-Rolled Ti Alloy with Dexamethasone-Loaded Graphene for Dental Applications

Shih

et al. 2015

Metals

Self Cite

Ultrafine-grained (UFG) Ti-6Al-4V alloy has attracted attention from the various industries due to its good mechanical properties. Although severe plastic deformation (SPD) processes can produce such a material, its dimension is generally limited to laboratory scale. The present work utilized the multi-pass caliber-rolling process to fabricate Ti-6Al-4V bulk rod with the equiaxed UFG microstructure. The manufactured alloy mainly consisted of alpha phase and showed the fiber texture with the basal planes parallel to the rolling direction. This rod was large enough to be used in the industry and exhibited comparable tensile properties at room temperature in comparison to SPD-processed Ti-6Al-4V alloys. The material also showed good formability at elevated temperature due to the occurrence of superplasticity. Internal-variable analysis was carried out to measure the contribution of deformation mechanisms at elevated temperatures in the manufactured alloy. This revealed the increasing contribution of phase/grain-boundary sliding at 1073 K, which explained the observed superplasticity.

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

Manufacturing Ultrafine-Grained Ti-6Al-4V Bulk Rod Using Multi-Pass Caliber-Rolling

Shih

et al. 2015

Metals

Self Cite

J Biomedical Materials Res

“…53 The type of the MSCs in fifteen studies 19,32,36,40,[54][55][56][57][58][59][60][61][62][63][64] was not defined. Sixteen studies used preosteoblast cells, 14,[65][66][67][68][69][70][71][72][73][74][75][76][77][78][79] including mouse osteoblastic cells 14, 65-74, 77-82 (MC3T3-E1) and rat calvarial osteoprogenitors, 75 while the type of the preosteoblast cells in one study 76 was not defined. Five articles 13, 83-86 used osteoblasts.…”

Section: Cell Sourcesmentioning

confidence: 99%

“…Graphene has unique physiochemical features, especially its potential for osteogenic induction of stem cells, that make it a promising material for promoting surface modification and bioactive character of metal-based composites. 48 Several studies 13,26,28,45,47,50,65,69,71,76,86,89,92 raised a debate regarding the influential role of metals combined with graphene on cell proliferation and viability.…”

Section: Graphene and Metalsmentioning

confidence: 99%

In vitro effect of graphene structures as an osteoinductive factor in bone tissue engineering: A systematic review

Mohammadrezaei

Golzar

Rad

et al. 2018

Graphene and its derivatives have been well-known as influential factors in differentiating stem/progenitor cells toward the osteoblastic lineage. However, there have been many controversies in the literature regarding the parameters effect on bone regeneration, including graphene concentration, size, type, dimension, hydrophilicity, functionalization, and composition. This study attempts to produce a comprehensive review regarding the given parameters and their effects on stimulating cell behaviors such as proliferation, viability, attachment and osteogenic differentiation. In this study, a systematic search of MEDLINE database was conducted for in vitro studies on the use of graphene and its derivatives for bone tissue engineering from January 2000 to February 2018, organized according to the PRISMA statement. According to reviewed articles, different graphene derivative, including graphene, graphene oxide (GO) and reduced graphene oxide (RGO) with mass ratio ≤1.5 wt % for all and concentration up to 50 μg/mL for graphene and GO, and 60 μg/mL for RGO, are considered to be safe for most cell types. However, these concentrations highly depend on the types of cells. It was discovered that graphene with lateral size less than 5 µm, along with GO and RGO with lateral dimension less than 1 µm decrease cell viability. In addition, the three-dimensional structure of graphene can promote cell-cell interaction, migration and proliferation. When graphene and its derivatives are incorporated with metals, polymers, and minerals, they frequently show promoted mechanical properties and bioactivity. Last, graphene and its derivatives have been found to increase the surface roughness and porosity, which can highly enhance cell adhesion and differentiation. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 2284-2343, 2018.

“…14,15 It is noted that the WR Ti-13Nb-13Zr exhibited the superior tensile properties in comparison to other forms of Ti-13Nb-13Zr alloy as discussed in our previous work; the WR alloy exhibited a tensile stress of 1,050 MPa, while both HR alloy and ASTM Ti-13Nb-13Zr possessed the value of 850 MPa. 16,17 Moreover, the WR alloy exhibited the higher hardness (HV 335±5) than the HR alloy (HV 215±4) as well as the solution-treated and cold-rolled sample (HV 285±7). 18 This is understood by the conclusion that Ti-13Nb-13Zr exhibits a higher hardness when it consists of the finer microstructural features.…”

mentioning

confidence: 98%

Tribological and corrosion behaviors of warm- and hot-rolled Ti-13Nb-13Zr alloys in simulated body fluid conditions

Lee¹,

Mathew²,

Rajaraman³

et al. 2015

IJN

Self Cite

Development of submicrocrystalline structure in biomedical alloy such as Ti-13Nb-13Zr (in wt%) through warm-rolling process has been found to enhance mechanical properties compared to conventional thermomechanical processing routes including hot-rolling process. The present study investigated the tribological and corrosion behaviors of warm-rolled (WR) and hot-rolled Ti-13Nb-13Zr alloys which have not been studied to date. Both tribological and corrosion experiments were carried out in simulated body fluid conditions (Hank’s solution at 37°C) based on the fact that the investigated alloys would be used in a human body as orthopedic implants. The WR Ti-13Nb-13Zr demonstrated a submicrocrystalline structure that provided a significant enhancement in hardness, strength, and corrosion resistance. Meanwhile, there was no notable difference in wear resistance between the WR and hot-rolled samples despite the different microstructure and hardness. The present study confirmed the enormous potential of WR Ti-13Nb-13Zr with not only great mechanical properties but also high corrosion resistance in the simulated body fluid.