Surface modification of Mg-doped fluoridated hydroxyapatite nanoparticles using bioactive amino acids as the coupling agent for biomedical applications

Fereshteh, Zeinab; Mallakpour, Fereshteh; Fathi, Mohammadhossein; Mallakpour, Shadpour; Bagri, Akbar

doi:10.1016/j.ceramint.2015.04.101

Cited by 27 publications

(14 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In order to reduce agglomeration of NPs, a modification on the NP surface is suggested which in turn leads to improve interaction of the hydrophilic surface of NPs and hydrophobic polymer molecules. 27 By this strategy, the biological properties of the fibrous nanocomposite scaffolds would be improved because of not only appropriately dispersion of NPs in the polymer matrix but also obtaining thinner and more uniform fibers. In addition, it is possible to load higher concentration of well-dispersed bio-ceramic nanoparticle sin the polymer fibers and consequently enhancing biological properties.…”

Section: Discussionmentioning

confidence: 99%

“…According to Table 5, the optimum levels were presented as A2, B1, C2, D2, andE1, that is, the optimum sample tion, there were no extra peaks and/or shift in the XRD pattern of fibrous nanocompositescaffold. 10,27 The distribution of Mg-FA NPs in PCL matrix was investigated by TEM. According to Figure 6, the Mg-FA NPs acceptably were welldispersed inside the PCL nanofibers as a polymeric matrix, despite of However, to increase the concentration of NPs, it is possible to improve NP dispersity by modifying their surface.…”

Section: Prediction Of the Optimum Conditions By Taguchi Methods To mentioning

confidence: 99%

“…According to Figure 6, the Mg-FA NPs acceptably were welldispersed inside the PCL nanofibers as a polymeric matrix, despite of However, to increase the concentration of NPs, it is possible to improve NP dispersity by modifying their surface. 10,27 Bioactivity and cell attraction of the optimized Mg-FA NPs/PCL The results of cell adhesion of the scaffold is shown in Figure 7B.…”

Section: Prediction Of the Optimum Conditions By Taguchi Methods To mentioning

confidence: 99%

See 2 more Smart Citations

Implementing Taguchi method to analyze electrospinning parameters influence on Mg‐doped fluorapatite nanoparticles‐poly (ε‐caprolactone) nanocomposite scaffold (Mg‐FA NPs/PCL) properties

Fereshteh

Fathi

Kargozar

et al. 2020

Polymers for Advanced Techs

Self Cite

View full text Add to dashboard Cite

The present study focused on an investigation of significant electrospinning parameters on Mg-doped fluorapatite nanoparticles-poly (ε-caprolactone) fibrous nanocomposite scaffold (Mg-FA NPs/PCL). Since there are many factors that could have an influence on electrospinning process, Taguchi experimental design approach was used to reduce the number of experiments. The selected parameters included the concentration of polymer, solvent system, ceramic concentration, applied voltage, and the distance between nozzle and collector. The analysis of variance (ANOVA) showed that, among the studied parameters, polymer concentration and type of solvent had the most significant effect on the consistency of the solution which played a major role in producing uniform non-beaded fibers. In order to maximize performance of electrospun scaffold, the surface tension should be kept minimizing by decreasing concentration, applying a high dielectric solvent system, increasing voltage, and declining distance in a very stable electrical field. Eventually, the optimum condition to fabricate Mg-FA NPs/PCL fibrous scaffold was electrospinning 10 wt% PCL with 1 wt% Mg-FA NPs solution in chloroform by applying 20 kV into 20 cm distance. According to the bioactivity and cell attachment results, the electrospun Mg-FA NPs/PCL is suggested as a promising candidate for tissue engineering, especially for bone tissue. K E Y W O R D S biological properties, electrospinning parameters, nanoparticles, Taguchi method, tissue engineering 1 | INTRODUCTION Recently, electrospinning has been applied as an appropriate and effective technique to produce biomimetic nanofibrous scaffolds consisting of a vast web of interconnected fibers and pores. 1-4 The structure of bone extracellular matrix (ECM) includes a fibrous collagen with homogeneously dispersed hydroxyapatite (HA) nanocrystals, therefore, applying electrospun scaffolds for bone tissue engineering has interestingly been increased. A numerous polymers have been employed to engineer the ECM tissues including either as natural polymers such as collagen, gelatin, chitosanor as synthetic polymers for example poly (lactic acid) (PLA), poly (lactide-co-glycolide) (PLGA), poly (glycolic acid) (PGA), polyurethane (PU), poly (ethylene glycol) diacrylate (PEGDA), and poly (ε-caprolactone) (PCL). 1-3,5-9 Owing to the appropriate mechanical properties and controllable degradation rate of synthetic polymers, researchers are extensively interested in

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Prediction Of the Optimum Conditions By Taguchi Methods To mentioning

confidence: 99%

Section: Prediction Of the Optimum Conditions By Taguchi Methods To mentioning

confidence: 99%

See 1 more Smart Citation

Implementing Taguchi method to analyze electrospinning parameters influence on Mg‐doped fluorapatite nanoparticles‐poly (ε‐caprolactone) nanocomposite scaffold (Mg‐FA NPs/PCL) properties

Fereshteh

Fathi

Kargozar

et al. 2020

Polymers for Advanced Techs

Self Cite

View full text Add to dashboard Cite

show abstract

“…The MnO 2 has wide applications in removal of heavy metal ion [13][14][15][16][17] , catalysts 18,19 , energy storage systems including batteries and supercapacitors [20][21][22][23] . L-valine is a branched-chain amino acid with suitable biodegradability, biocompatibility, nontoxic and ecofriendly properties, that obtained by hydrolysis of proteins 7,27,28 . The α-MnO 2 with 2 × 2 tunnel structure with wide tunnel size (0.46 nm) and large surface area 26 is suitable for adsorption heavy metal ions.…”

Section: Introductionmentioning

confidence: 99%

Covalent surface modification of α-MnO₂ nanorods with l-valine amino acid by solvothermal strategy, preparation of PVA/α-MnO₂-l-valine nanocomposite films and study of their morphology, thermal, mechanical, Pb(ii) and Cd(ii) adsorption properties

Mallakpour

Motirasoul

2016

RSC Adv.

Self Cite

View full text Add to dashboard Cite

Correspondence: Shadpour Mallakpour,The surface of α-manganese dioxide (α-MnO 2 ) nanorods was modified chemically with L-valine amino acid by solvothermal strategy. The α-MnO 2 nanorods were prepared by a hydrothermal method. Then poly(vinyl alcohol)/α-MnO 2 -L-valine nanocomposites (NCs) containing 1, 3 and 5 wt% of modified α-MnO 2 nanorods were prepared through ultrasound-assisted technique.Fourier transform infrared spectroscopy, X-ray diffraction, field emission scanning electron microscopy, transmission electron microscopy and UV-Visible spectroscopy were used to investigate and characterize nanostructures and NCs. Following, effects of α-MnO 2 -L-valine nanorods on the properties of NCs such as mechanical and thermal properties were studied. TheBrunauer-Emmett-Teller (BET) results were showed NC 3 wt% had higher surface area, pore volume and pore size than pure PVA with meso-porous structure. Finally, adsorption behavior of NC 3 wt% was investigated as an adsorbent for sorption of Pb(II) and Cd(II) ions. It showed good adsorption potential for the removal of Pb(II) and Cd(II) in aqueous solution. Fig 4. UV-Visible absorbance spectra of (A) α-MnO 2 , α-MnO 2 -L-valine nanorods, (B) pure PVA (a), PVA/α-MnO 2 -L-valine NC film 1 wt% (b), PVA/α-MnO 2 -L-valine NC film 3 wt% (c) and PVA/α-MnO 2 -L-valine NC film 5 wt% (d). Mechanical propertiesThe mechanical tests, including the E-modulus, tensile strength and elongation at break, were performed to study the effect of modified α-MnO 2 nanorods on the mechanical properties of PVA. The tensile stress-strain curves of pure PVA and NC films containing 1, 3 and 5 wt% of α-MnO 2 /L-valine nanorods are shown in Figure 5 and the results are summarized in Table 2.Several factors can be affected on the mechanical properties of NCs such as particle size and morphology, particle loading and distribution, the polymer matrix and interfacial adhesion between modified α-MnO 2 and polymer. The tensile strength and E-modulus are increased in

show abstract

“…In our previous work, the surface of Mg‐FHA NPs was modified by different bioactive amino acids to improve NPs dispersion in the polymer matrix . To the best of our knowledge, there is no report on using chiral diacid based coupling agent in the preparation of bionanocomposite between MFA and PVP matrix.…”

Section: Introductionmentioning

confidence: 99%

Production of polyvinylpyrrolidone/chiral diacid modified nanocrystalline Mg‐substituted fluorapatite nanocomposites: Morphological and thermal characterization

Mallakpour

Khani

Mallakpour

et al. 2016

J of Applied Polymer Sci

Self Cite

View full text Add to dashboard Cite

The main objective of this work was the production of novel polyvinylpyrrolidone/diacid modified Mg‐substituted fluorapatite (DM‐MFA) nanocomposites (NC)s, by sonication process. Mg‐substituted fluorapatite (MFA) powders with a chemical composition of Ca9.5Mg0.5(PO4)6F2 were prepared by mechanical alloying technique. Initially, surface of MFA was modified by bioactive chiral diacid monomer, N‐trimellitylimido‐l‐leucine as a coupling agent to form DM‐MFA nanoparticles. DM‐MFA NPs were utilized as a filler, to give the NCs with potential bioactivity. Examination of transmission electron microscopy (TEM), and field emission scanning electron microscopy (FE‐SEM) microphotographs displayed that, there is no aggregation of a large quantity of particles. The above NCs showed rather improved thermal stability compared with pure polymer. The improvement of thermal behavior was related to the uniform and good dispersion of DM‐MFA in the polymer matrix as well as the strong hydrogen bonding between CO of PVP and OH of DM‐MFA. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 44254.

show abstract

Surface modification of Mg-doped fluoridated hydroxyapatite nanoparticles using bioactive amino acids as the coupling agent for biomedical applications

Cited by 27 publications

References 24 publications

Implementing Taguchi method to analyze electrospinning parameters influence on Mg‐doped fluorapatite nanoparticles‐poly (ε‐caprolactone) nanocomposite scaffold (Mg‐FA NPs/PCL) properties

Implementing Taguchi method to analyze electrospinning parameters influence on Mg‐doped fluorapatite nanoparticles‐poly (ε‐caprolactone) nanocomposite scaffold (Mg‐FA NPs/PCL) properties

Covalent surface modification of α-MnO₂ nanorods with l-valine amino acid by solvothermal strategy, preparation of PVA/α-MnO₂-l-valine nanocomposite films and study of their morphology, thermal, mechanical, Pb(ii) and Cd(ii) adsorption properties

Production of polyvinylpyrrolidone/chiral diacid modified nanocrystalline Mg‐substituted fluorapatite nanocomposites: Morphological and thermal characterization

Contact Info

Product

Resources

About

Surface modification of Mg-doped fluoridated hydroxyapatite nanoparticles using bioactive amino acids as the coupling agent for biomedical applications

Cited by 27 publications

References 24 publications

Implementing Taguchi method to analyze electrospinning parameters influence on Mg‐doped fluorapatite nanoparticles‐poly (ε‐caprolactone) nanocomposite scaffold (Mg‐FA NPs/PCL) properties

Implementing Taguchi method to analyze electrospinning parameters influence on Mg‐doped fluorapatite nanoparticles‐poly (ε‐caprolactone) nanocomposite scaffold (Mg‐FA NPs/PCL) properties

Covalent surface modification of α-MnO2 nanorods with l-valine amino acid by solvothermal strategy, preparation of PVA/α-MnO2-l-valine nanocomposite films and study of their morphology, thermal, mechanical, Pb(ii) and Cd(ii) adsorption properties

Production of polyvinylpyrrolidone/chiral diacid modified nanocrystalline Mg‐substituted fluorapatite nanocomposites: Morphological and thermal characterization

Contact Info

Product

Resources

About

Covalent surface modification of α-MnO₂ nanorods with l-valine amino acid by solvothermal strategy, preparation of PVA/α-MnO₂-l-valine nanocomposite films and study of their morphology, thermal, mechanical, Pb(ii) and Cd(ii) adsorption properties