Surface modification of Fe3O4 magnetic nanoparticles with (S)-naproxen

Abstract

Fe 3 O 4 magnetic nanoparticles (MNPs) were obtained using the gas condensation method. These MNPs were modified with 3 aminopropylsilane (APS) through covalent bonding. The methods of qualitative and quantitative analysis of the modified MNPs were developed using UV and IR spectroscopy and induc tively coupled plasma emission spectrometry (ICP ES). It was established that the maximum loading level of APS on the surface of Fe 3 O 4 MNPs was 0.91 mmol/g MNP. The study of the activity of the surface amino groups of the nanocomposites was carried out by the example of their modification with (S) naproxen. The optimum conditions for coupling reaction were found. It was shown that the reaction proceeded most effi ciently when using 1 ethyl 3 (3 dimethylaminopropyl)carbodiimide (EDC) as coupling agent in the pres ence of 1 hydroxy 1H benzotriazole (HOBt). The maximum immobilization level of (S) naproxen on the Fe 3 O 4 MNP surface was 0.55 mmol/g MNP. Thus, the high reactivity of amino groups of the obtained nano composites was shown, making it possible to further modify them.

3-Aminopropylsilane-modified iron oxide nanoparticles for contrast-enhanced magnetic resonance imaging of liver lesions induced by <em>Opisthorchis felineus</em>

“…37,38 As a result, the MNPs containing amino groups on the surface (MNPs-NH 2 ; Figure 3 Figure 1A and B).…”

Quantitative Determination of 3-Aminopropylsilane on the Surface of FE3O4 Nanoparticles by Attenuated Total Reflection Infrared Spectroscopy

“…The APS-modifi ed MNP were prepared in analogy with previously described techniques [6][7][8]. IR spectroscopy confi rmed that APS was immobilized on the surface (Fig.…”

“…Magnetic materials are used routinely, e.g., in biology for magnetic separation of biomolecules and cells [4] or in chemistry for development of magnetic separation of catalysts [5]. A promising method for modifying iron-oxide nanoparticles (NP) consists of depositing an organic layer on MNP using functionalized alkoxysilanes, in particular, 3-aminopropyltrialkoxysilanes [6][7][8][9][10][11][12][13][14][15][16][17][18] that form an organosilicon layer with functional groups on the surface. This enables the NP to be modifi ed further.…”

“…IR spectroscopy is most often employed for a qualitative assessment of the degree of functionalization. As a rule, elemental analysis, inductively coupled plasma atomic-emission spectroscopy (AES), or thermogravimetric analysis (TGA) is used for a quantitative determination of the number of organic molecules on the MNP surface [6][7][8][10][11][12][13][14].…”

“…Fluorescence or UV/vis spectrometry can determine the number of free molecules remaining in solution [6][7][8][9][15][16][17]. For example, MNP with surface 3-aminopropylsilane (APS) groups were modifi ed covalently with rhodamine B [15], N-difl uorenylmethoxycarbonyl-L-lysine [6], or S-naproxene [7] (production of amide derivatives) or p-nitrobenzaldehyde (Schiff base formation) [16,17] in order to determine the concentration of surface amines.…”