Surface Modification of Carbon Nano tubes with Nystatin for Drug Delivery Applications

Uttekar, Pravin S.; Kulkarni, Akshata; Sable, P. N.; Chaudhari, P.

doi:10.5530/ijper.50.3.10

Cited by 8 publications

(1 citation statement)

References 6 publications

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“…Topical delivery of these particles showed drug restoration in the skin even after the wash‐off period of the drug from the skin 46 . The minimum concentration required to produce fungicidal activity of Nystatin was found to be 16 and 14 μg/mL for C. albicans and C. parapsilosis , respectively, when incorporated into multi‐walled carbon nanotubes, whereas, these values were 25 and 21 μg/mL, respectively, with conventional nystatin formulations 47 …”

Section: Nanoparticles Based Strategy For Fungal Infectionsmentioning

confidence: 99%

Emerging role of nanocarriers based topical delivery of anti‐fungal agents in combating growing fungal infections

Waghule

Sankar

Rapalli

et al. 2020

Dermatologic Therapy

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The incidences of fungal infections have greatly increased over the past few years, particularly in humid and industrialized areas. The severity of such infections ranges from being asymptomatic-mild to potentially life-threatening systemic infections. There are limited classes of drugs that are approved for the treatment of such infections like polyenes, azoles, and echinocandins. Some fungi have developed resistance to these drugs. Therefore, to counter drug resistance, intensive large scale studies on novel targeting strategies and formulations are being conducted, which have gained impetus lately. Conventional formulations have limitations such as higher doses, frequent dosing, and several side effects. Such limiting factors have paved the path for the emergence of nanotechnology and its applications. This further gave formulation scientists the possibility of encapsulating the existing potential drug moieties into nanocarriers, which when loaded into gels or creams provided prolonged release and improved permeation, thus giving on-target effect. This review thus discusses the newer targeting strategies and the role of nanocarriers that could be administered topically for the treatment of various fungal infections. Furthermore, this approach opens newer avenues for continued and sustained research in pharmaceuticals with much more effective outcomes.

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Section: Nanoparticles Based Strategy For Fungal Infectionsmentioning

confidence: 99%

Emerging role of nanocarriers based topical delivery of anti‐fungal agents in combating growing fungal infections

Waghule

Sankar

Rapalli

et al. 2020

Dermatologic Therapy

View full text Add to dashboard Cite

show abstract

Chemically Modified Carbon Nanotubes in Drug Delivery

Ghosh¹,

Thongmee²,

Mostafavi³

2022

Chemically Modified Carbon Nanotubes for Commercial Applications

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Carbon Nanotube Hybrid Materials: Efficient and Pertinent Platforms for Antifungal Drug Delivery

Chandra,

Reis,

Kundu

et al. 2023

Adv Materials Technologies

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Carbon nanotubes (CNTs) have emerged as the brightest nascent artifact to deliver antifungal drugs in drug delivery applications, health care, and pharmaceutical industries. Excellent physio‐chemical features such as huge surface area, tunable side wall, and microneedle‐like morphology make CNTs suitable for drug carriers. Chemical attachments (covalent and non‐covalent functionalization) result in the formation of functionalized CNTs (F‐CNTs) and CNT‐based hybrid materials (CNT‐HMs). These F‐CNTs and CNT‐HMs have substantial antifungal activity and also have the potential to immobilize antifungal drugs such as amphotericin B, nystatin, curcumin, etc. on the exterior or interior surface, securely transport to the target sites, permeate through bio‐barriers, and release these drugs in a controlled manner. As antifungal drug carriers, F‐CNT and CNT‐HMs exhibit more excellent antifungal activity than other conventional drug delivery systems and have the potency to invade biofilm to circumvent the multidrug resistance of fungal species. This review focuses on CNTs and CNT‐HMs for antifungal drug delivery, including their functionalization methods, drug loading approaches, drug release mechanism, cellular internalization, delivery efficiency, and cellular toxicities with their workaround.

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Surface Modification of Carbon Nano tubes with Nystatin for Drug Delivery Applications

Cited by 8 publications

References 6 publications

Emerging role of nanocarriers based topical delivery of anti‐fungal agents in combating growing fungal infections

Emerging role of nanocarriers based topical delivery of anti‐fungal agents in combating growing fungal infections

Chemically Modified Carbon Nanotubes in Drug Delivery

Carbon Nanotube Hybrid Materials: Efficient and Pertinent Platforms for Antifungal Drug Delivery

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