Surface modification of biomaterials and biomedical devices using additive manufacturing

Abstract

It is widely understood that the success of implanted medical devices depends largely on favorable material-tissue interactions. Additive manufacturing has gained traction as a viable and unique approach to engineered biomaterials, for both bulk and surface properties that improve implant outcomes. This review explores how additive manufacturing techniques have been and can be used to augment the surfaces of biomedical devices for direct clinical applications.

Surface Modification of Biomedical Titanium Alloy: Micromorphology, Microstructure Evolution and Biomedical Applications

“…A great amount of researchers have focused on exploring the effect of morphology and composition of bioceramics surface on implants. The mechanical properties and biological responses of the coatings can be controlled accurately by biomimetic design of the roughness and graded porosity of the coatings without affecting the chemical structure of the matrix [86,87]. In this case, calcium phosphate coatings with different morphologies by changing the pulse frequency were obtained, as reported by Paital et al [88].…”

Introduction

“…Therefore, some finishing operation may be necessary for the final product. 7 For 3D-printed ceramic elements, process optimization and reproducibility are still primary challenges. Similarly, for 3D-printed metal parts, loosely bound powders can be of serious concern in vivo.…”

Investigation of In-Vitro Properties of NiTi Alloy After Micro Arc Oxidation

“…Biyomedikal uygulamalarda kullanılan biyomalzemeler; kendisini çevreleyen dokular ile normal etkileşime giren dokuda iltihaplanma, pıhtı oluşumu, kireçlenme, doku uyuşmazlığı gibi olumsuz tepkiler oluşturmayan, sürekli veya belirli aralıklarla kan ya da doku sıvısı gibi vücut akışkanlarıyla temas halinde olan, doğal veya sentetik malzemelerdir [1][2][3]. Biyomalzemeler organ ve dokuların azalan aktivitelerini arttırmak için canlı bir yapının bir parçasını oluşturabildikleri gibi doğal bir fonksiyonu geliştirmek ya da değiştirmek için kullanılan biyomedikal bir aracın herhangi parçasını da oluşturabilmektedirler [4]. Yüksek mekanik dayanıma sahip olan metalik biyomalzemeler, sert doku implantlarında (yapay kalça eklemleri, kemik plakaları, diş implantları vb.)…”