Surface Modification of Bamboo Charcoal by O2 Plasma Treatment and UV-Grafted Thermo-Sensitive AgNPs Hydrogel to Improve Antibacterial Properties in Biomedical Application

Abstract

With the advancement of science and modern medical technology, more and more medical materials and implants are used in medical treatment and to improve human life. The safety of invasive medical materials and the prevention of infection are gradually being valued. Therefore, avoiding operation failure or wound infection and inflammation caused by surgical infection is one of the most important topics in current medical technology. Silver nanoparticles (AgNPs) have minor irritation and toxicity to cells and have a broad-spectrum antibacterial effect without causing bacterial resistance and other problems. They are also less toxic to the human body. Bamboo charcoal (BC) is a bioinert material with a porous structure, light characteristics, and low density, like bone quality. It can be used as a lightweight bone filling material. However, it does not have any antibacterial function. This study synthesized AgNPs under the ultraviolet (UV) photochemical method by reducing silver nitrate with sodium citrate. The formation and distribution of AgNPs were confirmed by UV-visible spectroscopy and X-ray diffraction measurement (XRD). The BC was treated by O2 plasma to increase the number of polar functional groups on the surface. Then, UV light-induced graft polymerization of N-isopropyl acrylamide (NIPAAm) and AgNPs were applied onto the BC to immobilize thermos-/antibacterial composite hydrogels on the BC surface. The structures and properties of thermos-/antibacterial composite hydrogel-modified BC surface were characterized by Scanning Electron Microscopy (SEM), Fourier Transform Infrared spectrum (FT-IR), and X-ray photoelectron spectroscopy (XPS). The results show that thermos-/antibacterial composite hydrogels were then successfully grafted onto BC. SEM observations showed that the thermos-/antibacterial composite hydrogels formed a membrane structure between the BC. The biocompatibility of the substrate was evaluated by Alamar Blue cell viability assay and antibacterial test in vitro.

Atmospheric-Pressure Plasma Jet-Induced Graft Polymerization of Composite Hydrogel on 3D-Printed Polymer Surfaces for Biomedical Application

“…Moreover, UV light graft polymerization technology can achieve the purpose of selectively grafting and crosslinking monomers with different functional groups. Currently, UV light graft polymerization is one of the primary methods for synthesizing hydrogels in the biomedical field [35][36][37]. Due to its wide application, the UV light polymerization method has received considerable attention.…”

Single-Particle Electrochemical Imaging Provides Insights into Silver Nanoparticle Dissolution at the Solution–Solid Interface

“…Silver (Ag) nanoparticles have exciting applications in broad fields ranging from spectroscopy and catalysis to medical treatment due to their excellent optical, catalytic, and broad-spectrum antibiotic properties. − The rapid growth in the production and utilization of Ag nanoparticle-containing products has led to an inevitable increase in the level of Ag nanoparticles released into the aquatic environment, which could have unintended detrimental ecological impacts. , The oxidative dissolution of released Ag nanoparticles is a critical environmental transformation that governs the form and concentration of silver to which aquatic organisms are exposed. This transformation can alter nanoparticle properties and is considered a pivotal determinant of the environmental toxicity and safety of Ag nanoparticles .…”