Surface modification of a new flexible polymer with improved cell adhesion

Klee, Doris; Villari, R. V.; Höcker, Hartwig; Dekker, B.G.; Mittermayer, Ch.

doi:10.1007/bf00120336

Cited by 28 publications

(23 citation statements)

References 5 publications

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“…A number of studies reported the influence of physic-chemistry of the surface toward biological response of viable cells such as hydrophobicity and hydrophilicity of materials 196,198,[325][326][327][328][329][330] . An addition of glycerine was reported to improve the hydrophobicity and lead to a positive biological response of viable cells on the substrate 60,331,332 .…”

Section: Cell Proliferationmentioning

confidence: 99%

Polyelectrolyte complex materials from chitosan and gellan gum

Amin

Panhuis

2011

Carbohydrate Polymers

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Section: Cell Proliferationmentioning

confidence: 99%

Polyelectrolyte complex materials from chitosan and gellan gum

Amin

Panhuis

2011

Carbohydrate Polymers

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“…Although many surface treatments particularly for polymeric materials, e.g., using plasma, corona treatments, etc., have been developed to this end, e.g., to induce hydrophilic/ hydrophobic surfaces etc., and are state of the art, work on coatings that permit specific and local functionalization with persistent effects is still lacking. [9][10][11][12] One might argue that this is already realized in TiO 2 -based materials that can be functionalized using UV irradiation. [13][14][15][16] Unfortunately the properties hitherto achieved, in terms of superhydrophilicity and bactericidity, subside when the UV irradiation is shut-off.…”

Section: Introductionmentioning

confidence: 99%

Versatile Nanocomposite Coatings with Tunable Cell Adhesion and Bactericidity

Fischer-Brandies¹,

Es‐Souni²

2008

Adv Funct Materials

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TiO2‐Ag nanocomposites are known for their bactericidal effect during exposure to appropriate UV radiation. While involving hazardous radiation, and limited to accessible areas, the bactericidity of these coatings is not persistent in the absence of UV light, which impedes their commercial application. Herein it is shown that TiO2‐Ag nanocomposites can be made highly bactericidal without the need of irradiation. Beyond this, bactericidity can even be mitigated in the presence of pre‐irradiated coatings. Biocompatibility and cell adhesion are also negligibly small for the as‐processed, non‐irradiated coatings, and become fairly high when the coatings are irradiated prior to testing. This opens the possibility to pattern the coatings into areas with high and low cell adhesion properties. Indeed by irradiating the coating through a mechanical mask it is shown that fibroblast cell adherence is sharply confined to the irradiated area. These properties are achieved using TiO2‐Ag thin films with high silver loadings of 50 wt%. The films are processed on stainless steel substrates using solution deposition. Microstructural characterization by means of X‐ray diffraction, Raman, and X‐ray photoelectron spectroscopy, high‐resolution scanning electron microscopy, and atomic force microscopy show a highly amorphous TiO2‐AgxO nanocomposite matrix with scattered silver nanoparticles. UV irradiation of the films results in the precipitation of a high density of silver nanoparticles at the film surface. Bactericidal properties of the films are tested on α‐haemolyzing streptococci and in‐vitro biocompatibility is assessed on primary human fibroblast cultures. The results mentioned above as to the tunable bactericidity and biocompatibility of the TiO2‐Ag coatings developed herein, are amenable to silver ion release, to catalytic effects of silver nanoparticles, and to specific wettabilities of the surfaces.

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“…Previous studies with plasma modified surfaces used different substrates and process conditions, and produced contradictory results [1][2][3][4][5][6]; in addition, there was inadequate chemical characterization of surface composition. The latter is the focus of this study, forming the foundation for the subsequent protein adsorption studies.…”

Section: Introductionmentioning

confidence: 99%