Surface modification and local orientations of surface molecules in nanotherapeutics

Amin, Md. Lutful; Joo, Jae Yeon; Yi, Dong Kee; An, Seong Soo A.

doi:10.1016/j.jconrel.2015.04.017

Cited by 48 publications

(30 citation statements)

References 144 publications

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“…Nanoparticle-unique physicochemical properties may affect the biodistribution of both the nanoparticle and the drug it carries [82], which creates a significant challenge for in vitro tests. For example, the myelosuppression test, which is commonly used in immunotoxicity studies, evaluates the effect of a test substance on bone marrow precursors.…”

Section: Challenges and Considerationsmentioning

confidence: 99%

Pre-clinical immunotoxicity studies of nanotechnology-formulated drugs: Challenges, considerations and strategy

Dobrovolskaia

2015

Journal of Controlled Release

160

126

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Assorted challenges in physicochemical characterization, sterilization, depyrogenation, and in the assessment of pharmacology, safety, and efficacy profiles accompany preclinical development of nanotechnology-formulated drugs. Some of these challenges are not unique to nanotechnology and are common in the development of other pharmaceutical products. However, nanoparticle-formulated drugs are biochemically sophisticated, which causes their translation into the clinic to be particularly complex. An understanding of both the immune compatibility of nanoformulations and their effects on hematological parameters is now recognized as an important step in the (pre)clinical development of nanomedicines. An evaluation of nanoparticle immunotoxicity is usually performed as a part of a traditional toxicological assessment; however, it often requires additional in vitro and in vivo specialized immuno- and hematotoxicity tests. Herein, I review literature examples and share the experience with the NCI Nanotechnology Characterization Laboratory assay cascade used in the early (discovery-level) phase of pre-clinical development to summarize common challenges in the immunotoxicological assessment of nanomaterials, highlight considerations and discuss solutions to overcome problems that commonly slow or halt the translation of nanoparticleformulated drugs toward clinical trials. Special attention will be paid to the grandchallenge related to detection, quantification and removal of endotoxin from nanoformulations, and practical considerations related to this challenge.

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Section: Challenges and Considerationsmentioning

confidence: 99%

Pre-clinical immunotoxicity studies of nanotechnology-formulated drugs: Challenges, considerations and strategy

Dobrovolskaia

2015

Journal of Controlled Release

160

126

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“…e coating with hydrophilic polymers/moieties, such as polyethylene glycol (PEG), polyethylene oxide (PEO), polyvinylpyrrolidone (PVP), polyacrylic acid, poloxamer, and poloxamine, has been proven one of the most promising approaches to avoid opsonization. Hydrophilic polymers on the surface of the nanocarrier repel other molecules by steric effects [60]. e use of PEG moieties on NP surface represents a polymer shield that can reduce the nonspecific scavenging of nanotherapeutics by RES.…”

Section: Np Surface Modification To Improve Distribution Propertiesmentioning

confidence: 99%

The Dual Role of the Liver in Nanomedicine as an Actor in the Elimination of Nanostructures or a Therapeutic Target

Baboci

Capolla

Cintio

et al. 2020

Journal of Oncology

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e development of nanostructures for therapeutic purpose is rapidly growing, following the results obtained in vivo in animal models and in the clinical trials. Unfortunately, the potential therapeutic efficacy is not completely exploited, yet. is is mainly due to the fast clearance of the nanostructures in the body. Nanoparticles and the liver have a unique interaction because the liver represents one of the major barriers for drug delivery. is interaction becomes even more relevant and complex when the drug delivery strategies employing nanostructures are proposed for the therapy of liver diseases, such as hepatocellular carcinoma (HCC). In this case, the selective delivery of therapeutic nanoparticles to the tumor microenvironment collides with the tendency of nanostructures to be quickly eliminated by the organ. e design of a new therapeutic approach based on nanoparticles to treat HCC has to particularly take into consideration passive and active mechanisms to avoid or delay liver elimination and to specifically address cancer cells or the cancer microenvironment. is review will analyze the different aspects concerning the dual role of the liver, both as an organ carrying out a clearance activity for the nanostructures and as target for therapeutic strategies for HCC treatment.

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“…Surfactants are generally used to provide dispersion stability and prevent aggregation problems. Surface modification changes the physicochemical properties of magnetic nanoparticles; thus, it affects biocompatibility (Guardia et al, 2007), cellular uptake (Song et al, 2015), toxicity (Amin et al, 2015), stability, aggregation, and size. Often used for nanoparticle surface modifications, avidin is a biomolecule and has a high affinity for the small-molecule vitamin biotin (Saleh et al, 2010;Lismont and Dreesen, 2012).…”

Section: Introductionmentioning

confidence: 99%

The comparison of antioxidant capacity and cytotoxic, anticarcinogenic,and genotoxic effects of Fe@Au nanosphere magnetic nanoparticles

Yegenoglu¹,

Aslım²,

Güven³

et al. 2017

Turk J Biol

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Magnetic gold nanoparticles are used in various biomedical, biochemistry, and biotechnology applications due to their controllable size distribution, long-term stability, reduced toxicity, and biocompatibility. Different coating materials, such as proteins, carbohydrates, lipids, and polyphenols, are applied to enhance the biocompatibility of nanoparticles. In this study, the effects of surface coatings of core-shell structured Fe@Au nanosphere magnetic nanoparticles with regard to antioxidant capacity and cytotoxic, anticarcinogenic, and genotoxic properties were investigated. The obtained results demonstrated that avidin-coated Fe@Au nanospheres had higher antioxidant capacities than uncoated nanospheres. Neither avidin-coated nor uncoated nanoparticles had a cytotoxic effect on normal cells (human gingival fibroblast cell line, HGF-1). In addition, they had anticarcinogenic effects on human cervical carcinoma (HeLa), human breast adenocarcinoma (MCF-7), and human colorectal adenocarcinoma (CCL-221). The genotoxic effects of nanoparticles were also evaluated with DNA tail damage ratio.

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Surface modification and local orientations of surface molecules in nanotherapeutics

Cited by 48 publications

References 144 publications

Pre-clinical immunotoxicity studies of nanotechnology-formulated drugs: Challenges, considerations and strategy

Pre-clinical immunotoxicity studies of nanotechnology-formulated drugs: Challenges, considerations and strategy

The Dual Role of the Liver in Nanomedicine as an Actor in the Elimination of Nanostructures or a Therapeutic Target

The comparison of antioxidant capacity and cytotoxic, anticarcinogenic,and genotoxic effects of Fe@Au nanosphere magnetic nanoparticles

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