Surface modification and evaluation of bacterial cellulose for drug delivery

The Nanofication and Functionalization of Bacterial Cellulose and Its Applications

“…Badshah et al developed BC matrices modified by surface acetylation with a 1 mL mixture of acetic acid and sulfuric acid, followed by the addition of acetic anhydride. BC matrices with surface modification were explored for drug loading and release, and the study's results demonstrated that this modification produced the desired properties [133]. Pertile et al chose to modify the BC surface with plasma to enhance its cell affinity, for which lyophilized BC sheets were treated within a plasma reactor, and fed with N 2 (100%), under the following conditions: time, 30 min; voltage, 425 V; current, 0.20 A; N 2 flow, 10 sccm; pressure, 4 mbar.…”

Latest Advances on Bacterial Cellulose‐Based Materials for Wound Healing, Delivery Systems, and Tissue Engineering

“…Biological assays showed that these patches have both high antioxidant and anti‐inflammatory activities, in addition to biocompatibility and sustained release of its cargo. Other study that demonstrates that a BC membrane can have multiple actions, is the study performed by Badshah et al., where BC was modified with acetic anhydride, to be able to be loaded with one of two drugs with very different natures, one poorly water soluble and the other highly water soluble. Before the reaction, the BC membranes were soaked with acetic acid.…”

“…In another study, two different molecules were loaded in a BC‐based composite, specifically serum albumin, which modulated the release of the other molecule, levofloxacin, reducing its cytotoxicity to undetected levels, without losing its antibacterial activity. These three mentioned studies, are a great example of the versatility of BC to further develop dermal patches for drug delivery systems, that can be laden with different molecules while maintaining properties of interest.…”

Bacterial cellulose: Application as drug delivery system

“…The chemical structure, the concentration of the drug loaded, the concentration of the surface modifier and the modifications pre and post-loading of the drug altered the physicochemical properties of the BC matrices, which in turn affected the drug release behavior. The obtained results demonstrated that the surface modifications were found to be effective for controlling the drug release properties demonstrating the potential these BC matrices for applications as modified drug delivery system (29).…”