Surface Interactions on Hydrogel Extended Wear Contact Lenses

Hart, Dean E.; Shih, Katherine Lu

doi:10.1097/00006324-198710000-00005

Cited by 29 publications

(14 citation statements)

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“…Improperly kept lenses showed pathogenic microbial associations. 12 Elander et al 13 suggested that lenses worn on an extendedwear basis for 1 week showed a trend toward a higher colonization rate (61%) than did daily-wear lenses (42%), but the difference was not statistically significant. Keay and Wilcox 14 compared the bacterial colonization of a high-Dk silicone hydrogel contact lens worn on a 30-night extended-wear basis to that of a low-Dk hydroxyethyl methacrylate-based lens worn on a 6-night extendedwear schedule.…”

Section: Discussionmentioning

confidence: 97%

Microbial Changes in Conjunctival Flora with 30-Day Continuous-Wear Silicone Hydrogel Contact Lenses

İskeleli

Bahar

Eroğlu

et al. 2005

Eye &Amp; Contact Lens: Science &Amp; Clinical Practice

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The results suggest that the sterility of the conjunctiva significantly decreased after using 30-day continuous-wear silicone hydrogel contact lenses. In addition, the number of bacteria of the normal conjunctival flora significantly increased after the use of these lenses. Contamination by the bacteria of the eyelids may be a possible colonization factor in this study group. Therefore, it is appropriate to examine the patients who wear these lenses more frequently.

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Section: Discussionmentioning

confidence: 97%

Microbial Changes in Conjunctival Flora with 30-Day Continuous-Wear Silicone Hydrogel Contact Lenses

İskeleli

Bahar

Eroğlu

et al. 2005

Eye &Amp; Contact Lens: Science &Amp; Clinical Practice

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“…Studies have shown that although lens handling was a significant source of lens contamination, lens wear significantly reduced the level of contamination. 67,71 Another study designed to investigate the influence of lens wear on bacterial adhesion, in which worn and new lenses were exposed to a bacterial suspension of S. epidermidis, showed that worn lotrafilcon A lenses contained a higher percentage of nonviable bacteria (47%) compared with unworn lenses (25%). 27 This would suggest that contamination rates being observed with unworn, handled-only lenses are likely to be lower once lenses are worn.…”

Section: Discussionmentioning

confidence: 99%

Effect of Daily Contact Lens Cleaning on Ocular Adverse Events during Extended Wear

Ozkan¹,

Rathi²,

Jara

et al. 2015

Optometry and Vision Science

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“…In fact, hand-transported microorganisms usually do not survive and colonize permanently on a lens surface when worn on a normal, healthy eye. 39 In 1992, Mowry-McKee et al performed a study where patients were given two sets of sterile lenses to handle. One set was handled and then worn for 5 hours, and the second set was handled only and then cultured.…”

Section: Bioburdenmentioning

confidence: 99%

Microbial Contamination of Contact Lenses, Lens Care Solutions, and Their Accessories: A Literature Review

Szczotka-Flynn

Pearlman

Ghannoum

2010

Eye &Amp; Contact Lens: Science &Amp; Clinical Practice

207

155

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Purpose A contact lens (CL) can act as a vector for microorganisms to adhere to and transfer to the ocular surface. Commensal microorganisms that uneventfully cohabitate on lid margins and conjunctivae and potential pathogens that are found transiently on the ocular surface can inoculate CLs in vivo. In the presence of reduced tissue resistance, these resident microorganisms or transient pathogens can invade and colonize the cornea or conjunctiva to produce inflammation or infection. Methods The literature was reviewed and used to summarize the findings over the last 30 years on the identification, enumeration, and classification of microorganisms adherent to CLs and their accessories during the course of normal wear and to hypothesize the role that these microorganisms play in CL infection and inflammation. Results Lens handling greatly increases the incidence of lens contamination, and the ocular surface has a tremendous ability to destroy organisms. However, even when removed aseptically from the eye, more than half of lenses are found to harbor microorganisms, almost exclusively bacteria. Coagulase-negative Staphylococci are most commonly cultured from worn lenses; however, approximately 10% of lenses harbor Gram-negative and highly pathogenic species, even in asymptomatic subjects. In storage cases, the incidence of positive microbial bioburden is also typically greater than 50%. All types of care solutions can become contaminated, including up to 30% of preserved products. Conclusions The process of CL-related microbial keratitis and inflammation is thought to be preceded by the presence or transfer or both of microorganisms from the lens to the ocular surface. Thus, this detailed understanding of lens-related bioburden is important in the understanding of factors associated with infectious and inflammatory complications. Promising mechanisms to prevent bacterial colonization on lenses and lens cases are forthcoming, which may decrease the incidence of microbially driven CL complications.

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Surface Interactions on Hydrogel Extended Wear Contact Lenses

Cited by 29 publications

References 0 publications

Microbial Changes in Conjunctival Flora with 30-Day Continuous-Wear Silicone Hydrogel Contact Lenses

Microbial Changes in Conjunctival Flora with 30-Day Continuous-Wear Silicone Hydrogel Contact Lenses

Effect of Daily Contact Lens Cleaning on Ocular Adverse Events during Extended Wear

Microbial Contamination of Contact Lenses, Lens Care Solutions, and Their Accessories: A Literature Review

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