Surface-hydrophilic and protein-resistant silicone elastomers prepared by hydrosilylation of vinyl poly(ethylene glycol) on hydrosilanes-poly(dimethylsiloxane) surfaces

Guo, Dongjie; Han, Huanmei; JingWang,; Xiao, Shou‐Jun; Zhang, Dai

doi:10.1016/j.colsurfa.2007.05.080

Cited by 59 publications

(46 citation statements)

References 38 publications

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“…Among the reported techniques, embedding (Huang et al 2006;Yu and Han 2006) and grafting Guo et al 2007) of polymer ''brushes'' onto PDMS surfaces are popular methods for permanent surface modification. In these cases, the polymers must contain hydrophilic chains, similar interfacial free energies compared to water, and large degrees of mobility (Norde et al 2005).…”

Section: Introductionmentioning

confidence: 99%

A silicone-based microfluidic chip grafted with carboxyl functionalized hyperbranched polyglycerols for selective protein capture

Yeh

Rossi

Kizhakkedathu

et al. 2009

Microfluid Nanofluid

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A poly(dimethylsiloxane) (PDMS)-based functional microfluidic device containing a charged matrix of PDMS pillar arrays grafted with hyperbranched polyglycerols (HPGs) was developed. Samples of PDMS were modified with allylamine plasma to form amine groups on the surface prior to the covalent grafting of succinimdyl ester-functionalized HPGs. The anionic functionality of the PDMS channel matrices was developed by altering the number of carboxyl groups present on the HPGs. The grafting of HPGs onto PDMS plates was investigated via contact angle measurement and attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR), while the grafting of the inside channel was investigated by electroosmotic flow (EOF) measurements. The charge density on grafted HPG was optimized to minimize the nonspecific protein adsorption and increase the selective capture of positively charged proteins. A proof-of-concept device was fabricated on PDMS and demonstrated that the device selectively captures positively charged protein (avidin) from a mixture of bovine serum albumin (BSA)-avidin at pH 7.4 in phosphate buffered saline (PBS). In order to increase the capture efficiency of the proteins in this PDMS-based device, pillar arrays have been fabricated within the channel. As a demonstration, the new device separated two proteins with an avidin capture efficiency of 100 ± 2.95% per 3 min from a 0.02 mg/ml protein solution (avidin:BSA wt ratio: 1:1). This new microfluidic-based device shows a great deal of promise as a tool for protein capture and analysis.

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Section: Introductionmentioning

confidence: 99%

A silicone-based microfluidic chip grafted with carboxyl functionalized hyperbranched polyglycerols for selective protein capture

Yeh

Rossi

Kizhakkedathu

et al. 2009

Microfluid Nanofluid

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“…Poly(ethylene glycol) (M = 3000) was obtained from Alfa Aesar (Johnson Matthey Company). Allyl-PEG was synthesized according to the literature [19]. Hydrogen fluoride (HF) (40%) and other reagents were of reagent grade and were used without further purification.…”

Section: Methodsmentioning

confidence: 99%

Macroporous silicon templated from silicon nanocrystallite and functionalized SiH reactive group for grafting organic monolayer

Guo¹,

Wang²,

Tan³

et al. 2009

Journal of Colloid and Interface Science

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“…A sharp single peak is observed in every spectrum at 1250 cm À1 , which is attributed to the deformation vibration of -CH 3 in Si-(CH 3 ) 2 group. 28 Compared to the general symmetric deformation vibration of -CH 3 in alkyl group, this vibration band takes a distinct red-shift. Similar FTIR spectrum was observed after O 2 plasma treatment, excepting that tiny broadband arises around 3420 cm À1 , which is due to the generation of -OH after O 2 plasma treatment.…”

Section: Surface Modification Of the Iol And Characterizationmentioning

confidence: 98%

Surface PEGylation of intraocular lens for PCO prevention: An in vivo evaluation

Tang

Han

et al. 2016

J Biomater Appl

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Posterior capsular opacification (PCO) is a common complication in cataract surgery. The development of PCO is attributed to the combination of adhesion, migration, proliferation, and transdifferentiation of the residual lens epithelial cells (LEC) onto the interface of intraocular lens (IOL) material and lens posterior, in which the initial adhesion is the beginning step and plays important roles. In the present study, hydrophilic polyethylene glycol (PEG) was immobilized onto IOL surface via plasma-aided chemical grafting procedure. The attenuated total reflection - Fourier transform infrared (ATR-FTIR) and contact angle (CA) - measurements indicate the successful surface PEGylation, as well as the excellent hydrophilicity of the surfaces. Compared with pristine IOL, the PEGylation does not influent its optical property, whereas the initial adhesion of LEC is greatly inhibited. In vivo ocular implantation results show that the PEGylated IOL presents good in vivo biocompatibility, and can effectively prevent the PCO development.

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Surface-hydrophilic and protein-resistant silicone elastomers prepared by hydrosilylation of vinyl poly(ethylene glycol) on hydrosilanes-poly(dimethylsiloxane) surfaces

Cited by 59 publications

References 38 publications

A silicone-based microfluidic chip grafted with carboxyl functionalized hyperbranched polyglycerols for selective protein capture

A silicone-based microfluidic chip grafted with carboxyl functionalized hyperbranched polyglycerols for selective protein capture

Macroporous silicon templated from silicon nanocrystallite and functionalized SiH reactive group for grafting organic monolayer

Surface PEGylation of intraocular lens for PCO prevention: An in vivo evaluation

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