Surface glycoproteins of malignant human leukocytes

Gahmberg, Carl G.; Andersson, Leif C.

doi:10.1016/0304-419x(82)90007-5

Cited by 16 publications

(6 citation statements)

References 89 publications

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“…They are more similar to patterns seen in leukaemic blasts representing undifferentiated erythroid cells (3). In case 2, the surface glycoprotein profile is similar to that of undifferentiated myeloid leukaemia in adults (3,9). As seen in Figure 3, the survival in this subgroup was poor.…”

Section: Discussionmentioning

confidence: 59%

“…The third subgroup (group 4) consists of patients whose leukaemic blasts expressed "odd" surface glycoprotein profiles. These profiles are not compatible with a lymphoid origin (9). They are more similar to patterns seen in leukaemic blasts representing undifferentiated erythroid cells (3).…”

Section: Discussionmentioning

confidence: 83%

“…One group consisted of cases where the leukaemic blasts expressed surface glycoprotein profiles which were of intermediate type with some features of mature T or B cells (Figure 2). Our earlier studies (9) indicate that these cells were of pre-T (or pre-B?) phenotype but they had not matured to express sheep red blood cell receptors of surface Ig.…”

Section: Discussionmentioning

confidence: 89%

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Identification of non‐T non‐B lymphocyte leukaemia patients with favourable prognosis by cell surface glycoprotein analysis

Siimes

Andersson

Gahmberg

1985

Scandinavian Journal of Haematology

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Leukaemic cells from 15 children with ALL were isolated and their surface glycoproteins labelled with 3H after treatment with neuraminidase and galactose oxidase followed by NaB3H4. The labelled glycoproteins were separated by polyacrylamide slab gel electrophoresis and visualized by flourography. The cells could be classified into four groups: 1) Surface glycoprotein pattern resembling that of normal T lymphocyte (one patient); 2) Surface glycoprotein pattern showing some T cell characteristics (5 patients); 3) Surface glycoprotein profile with strongly labelled glycoproteins of apparent molecular weight of 120 000 and 130 000, and frequently a glycoprotein with an apparent molecular weight of 210000 and visible HLA‐coded glycoproteins (6 patients); 4) Surface glycoprotein pattern not resembling those of the other groups (3 patients). Follow‐up showed that patients in group 3 have remained in their initial remission (5/6) for the complete study period of 5–6 yr, whereas all patients in the other groups have relapsed and/or died. We conclude that the surface glycoprotein analysis enables the identification of patients with non‐T non‐B ALL with favourable prognosis.

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Section: Discussionmentioning

confidence: 59%

Section: Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 89%

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Identification of non‐T non‐B lymphocyte leukaemia patients with favourable prognosis by cell surface glycoprotein analysis

Siimes

Andersson

Gahmberg

1985

Scandinavian Journal of Haematology

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“…This is typical of proteins rich in 0-glycosidic carbohydrate. Interestingly non-T acute lymphocytic and myeloid leukemias strongly expressed the protein, and often two closely spaced bands were observed [46,47].…”

Section: The Major Sialoglycoprotein Of Human Leukocytesmentioning

confidence: 99%

Major O‐glycosylated sialoglycoproteins of human hematopoietic cells: Differentiation antigens with poorly understood functions

Gahmberg

Autero

Hermonen

1988

J of Cellular Biochemistry

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All human hematopoietic cells seem to contain a major, heavily O-glycosylated sialoglycoprotein. Glycophorin A is specific for the erythroid lineage of cells, and leukocytes have a major sialoglycoprotein, also called leukosialin or sialophorin. Cell differentiation results in patterns of O-glycosylation in these proteins, which reflect the stage of differentiation within a cell lineage as well as lineage specificity. The altered carbohydrate compositions may influence the interactions of the cells with external ligands. Healthy individuals lacking glycophorin A in their red cells are known, whereas a deficiency of the leukocyte sialoglycoprotein may result in immunological disease. Although little is known about the physiological functions of these proteins, they form interesting models for studies on regulation of glycosylation, biosynthesis of O-glycosylated glycoproteins, and function of cell surface receptors.

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“…In an effort to accomplish this task, early studies of leukemia recognized the morphologic differences between lymphocytic and myelocytic leukemia. Further subgrouping, as in the identification of T-, B-, and non-T, non-B-cell lymphocytic subsets, has occurred by distinguishing cell surface markers on different normal lymphocytes as well as leukemic cells [ 1,2]. These subsets also have defined corresponding differences in the clinical courses of these diseases [2].…”

Section: Introductionmentioning

confidence: 99%

Childhood leukemia with simultaneously expressed myeloid and lymphoid markers suggesting stem cell origin

et al. 1985

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A case study is presented of a leukemic patient whose cells express markers of both myeloid and lymphoid cells. Cells were identified from bone marrow which expressed either myeloid antigens, lymphoid antigens, or both myeloid and lymphoid antigens, indicating a possible common stem cell capable of differentiating along either a lymphoid or myeloid cell lineage. Using specific monoclonal antibodies, 40-70% of the cells were reactive with anti-T-cell antibodies, 50% of the cells were reactive with antibodies to the common ALL antigen (CALLA), and 80-90% of the cells were reactive with antibodies directed against myeloid antigens. Using double staining techniques, some cells were found to demonstrate only myeloid markers; others, only lymphoid markers; and others, both myeloid and lymphoid markers. These results suggest that a common stem cell is capable of differentiating along both lymphoid and myeloid lineages.

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Surface glycoproteins of malignant human leukocytes

Cited by 16 publications

References 89 publications

Identification of non‐T non‐B lymphocyte leukaemia patients with favourable prognosis by cell surface glycoprotein analysis

Identification of non‐T non‐B lymphocyte leukaemia patients with favourable prognosis by cell surface glycoprotein analysis

Major O‐glycosylated sialoglycoproteins of human hematopoietic cells: Differentiation antigens with poorly understood functions

Childhood leukemia with simultaneously expressed myeloid and lymphoid markers suggesting stem cell origin

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